Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Éva Ágai-Csongor"'
Autor:
Istvan Gyertyan, Éva Hellinger, Mónika Vastag, Éva Ágai-Csongor, Olivér Éliás, György Domány, Bela Kiss, Aniko Gere, György M. Keserű
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2118-2122
This Letter describes our attempts to elaborate dually acting compounds possessing serotonin re-uptake transporter inhibitor and serotonin 5-HT2C receptor antagonist properties. A novel series of 1,3-diphenylureas and N-phenylbenzamides have thus bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e4100a1566d614d99a3d992309a973
https://doi.org/10.1016/j.bmcl.2014.03.043
https://doi.org/10.1016/j.bmcl.2014.03.043
Autor:
Mária Zájer-Balázs, Károly Tihanyi, Katalin Saghy, Mónika Vastag, Katalin Nogradi, Istvan Vago, Bela Kiss, Margit Kapás, István Greiner, Larisza Gémesi, Zsolt Szombathelyi, György M. Keserű, Éva Ágai-Csongor, Janos Galambos, Eva Schmidt, Istvan Gyertyan, György Domány, Judit Laszy, Aniko Gere, István Laszlovszky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3437-3440
Medicinal chemistry optimization of an impurity isolated during the scale-up synthesis of a pyridylsulfonamide type dopamine D3/D2 compound (1) led to a series of new piperazine derivatives having affinity to both dopamine D3 and D2 receptors. Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1e35c4f2a245e7be871e82a9552b3
https://doi.org/10.1016/j.bmcl.2012.03.104
https://doi.org/10.1016/j.bmcl.2012.03.104
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 48:388-397
Selective and sensitive LC-MS/MS methods have been developed and validated for simultaneous determination of RGH-188, a novel atypical antipsychotic, and its two active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine. Deuter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79a2668cdaaa2cd2154ebcd00884b40
https://doi.org/10.1016/j.jpba.2007.12.016
https://doi.org/10.1016/j.jpba.2007.12.016
Autor:
Istvan Laszlovszky, Ildikó Magdó, Eva Schmidt, György M. Keserü, Györgyi Ignacz-Szendrei, Katalin Nogradi, Judit Laszy, Larisza Gémesi, Attila Bielik, István Greiner, Éva Ágai-Csongor, György Domány, Mária Zájer-Balázs, Janos Galambos, Istvan Vago, Istvan Gyertyan, Bela Kiss, Katalin Saghy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5340-5344
A novel series of arylsulfonamides was prepared either by automated parallel or by traditional solution-phase synthesis. Several members of this compound library were identified as high-affinity dopamine D3 and D2 receptor ligands. The most interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6050a05a57420e300744aed9be2987ff
https://doi.org/10.1016/j.bmcl.2007.08.015
https://doi.org/10.1016/j.bmcl.2007.08.015
Publikováno v:
ACS medicinal chemistry letters. 5(9)
A sequential docking methodology was applied to computationally predict starting points for fragment linking using the human dopamine D3 receptor crystal structure and a human dopamine D2 receptor homology model. Two focused fragment libraries were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1afadb5eb71ba60aef93a1054361baa
https://pubmed.ncbi.nlm.nih.gov/25221658
https://pubmed.ncbi.nlm.nih.gov/25221658
Publikováno v:
Collection of Czechoslovak Chemical Communications. 61:1244-1247
While the reaction of some 2-substituted and 2,6-disubstituted phenols with isopropenyl acetate resulted in the corresponding phenol acetates, in the reaction of 2,6-di-tert-butylphenol, a useful starting material of antioxidant building blocks, unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b1e832700cc9b0c3658cc90b0110e0
https://doi.org/10.1135/cccc19961244
https://doi.org/10.1135/cccc19961244
Autor:
Attila Bielik, Horvath Csilla, Csilla Kiss, György Domány, József Nagy, G. Barta-Szalai, Éva Ágai-Csongor, Sándor Farkas, Borza Istvan, Éva Bozó, Aniko Gere, Sándor Kolok, Gábor Tárkányi, Béla Ágai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3859-3861
A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc025ee47c61f0b48996586ce052620
https://doi.org/10.1016/s0960-894x(03)00708-x
https://doi.org/10.1016/s0960-894x(03)00708-x
Autor:
István Gyertyán, Katalin Sághy, Judit Laszy, Ottilia Elekes, Rita Kedves, Larisza I. Gémesi, Gabriella Pásztor, Mária Zájer-Balázs, Margit Kapás, Éva Ágai Csongor, György Domány, Béla Kiss, Zsolt Szombathelyi
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 378(5)
RG-15 (trans-N-[4-[2-[4-(3-cyano-5-trifluoromethyl -phenyl) -piperazine -1 -yl] -ethyl] -cyclohexyl] -3 -pyridinesulfonic amide dihydro-chloride), is a highly selective dopamine D3/D2 receptor antagonist with subnanomolar affinity for the D3 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523a0af1b03cba73a5c4e51035e02a96
https://pubmed.ncbi.nlm.nih.gov/18548231
https://pubmed.ncbi.nlm.nih.gov/18548231
Autor:
Gyula Bugovics, Attila Horváth, Bela Kiss, Károly Fazekas, Zsolt Szombathelyi, Istvan Gyertyan, Zsolt Némethy, István Laszlovszky, Éva Ágai-Csongor, Eva Schmidt, György Domány
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 378(5)
RG-15 (trans-N-[4-[2-[4-(3-cyano-5-trifluoromethyl-phenyl)-piperazine-1-yl]-ethyl]-cyclohexyl]-3-pyridinesulfonic amide dihydrochloride) displayed subnanomolar affinity to human and rat dopamine D3 receptors (pKi 10.49 and 9.42, respectively) and nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad763985a4b795de64ef552ab4049c2b
https://pubmed.ncbi.nlm.nih.gov/18551280
https://pubmed.ncbi.nlm.nih.gov/18551280