Cost-effectiveness of the top 100 drugs by public spending in Canada, 2015–2021: a repeated cross-sectional study

Autor: Mina Tadrous, Étienne Gaudette, Shirin Rizzardo, Yvonne Zhang, Kevin R Pothier

Publikováno v: BMJ Open, Vol 14, Iss 3 (2024)

Objectives To assess the distribution and spending by cost-effectiveness category among those drugs with the highest public spending levels in Canada.Design Repeated cross-sectional study.Setting The Canadian provinces of Manitoba, Ontario, New Bruns

Externí odkaz: https://doaj.org/article/a084f3e5ebc341abb55d47c427966e1e

California Hospitals’ Rapidly Declining Traditional Medicare Operating Margins

Autor: Étienne Gaudette, Jay Bhattacharya

Publikováno v: Forum for Health Economics and Policy.

In recent years, Medicare margins of U.S. short-term acute care hospitals participating in the inpatient prospective payment system (IPPS) have declined nationally by over 10 percentage points, from 2.2% in 2002 to −8.7% in 2019. This trend conceal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caec70651c3eb7cf05fd733bfb012fa1
https://doi.org/10.1515/fhep-2022-0038

Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohortsResearch in context

Autor: Mart Kals, Lindsay Wilson, Daniel F. Levey, Livia Parodi, Ewout W. Steyerberg, Sylvia Richardson, Feng He, Xiaoying Sun, Sonia Jain, Aarno Palotie, Samuli Ripatti, Jonathan Rosand, Geoff T. Manley, Andrew I.R. Maas, Murray B. Stein, David K. Menon, Cecilia Ackerlund, Hadie Adams, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubović, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Marc Maegele, Marek Majdan, Alex Manara, Hugues Maréchal, Costanza Martino, Julia Mattern, Charles McFadyen, Catherine McMahon, Béla Melegh, Tomas Menovsky, Ana Mikolic, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Matej Oresic, Fabrizio Ortolano, Olubukola Otesile, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Dana Pisica, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Rădoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Veronika Rehorčíková, Isabel Retel Helmrich, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Ranjit D. Singh, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Nino Stocchetti, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Aurore Thibaut, Matt Thomas, Dick Tibboel, Marjolijn Timmers, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils Valeinis, Shirley Vallance, Zoltán Vámos, Mathieu van der Jagt, Joukje van der Naalt, Gregory Van der Steen, Jeroen T.J.M. van Dijck, Inge A. van Erp, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Ernest van Veen, Roel van Wijk, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Peter Vulekovic, Daniel Whitehouse, Eveline Wiegers, Guy Williams, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte, Tommaso Zoerle, Opeolu Adeoye, Neeraj Badjatia, Jason Barber, Michael Bergin, Kim Boase, Yelena Bodien, Randall Chesnut, John Corrigan, Karen Crawford, Ramon Diaz-Arrastia, Sureyya Dikmen, Ann-Christine Duhaime, Richard Ellenbogen, Venkata Feeser, Adam R. Ferguson, Brandon Foreman, Etienne Gaudette, Joseph Giacino, Luis Gonzalez, Shankar Gopinath, Ramesh Grandhi, Rao Gullapalli, Claude Hemphill, Gillian Hotz, Russell Huie, Ruchira Jha, Dirk C. Keene, Ryan Kitagawa, Frederick Korley, Joel Kramer, Natalie Kreitzer, Harvey Levin, Chris Lindsell, Joan Machamer, Christopher Madden, Alastair Martin, Thomas McAllister, Michael McCrea, Randall Merchant, Pratik Mukherjee, Lindsay Nelson, Laura B. Ngwenya, Florence Noel, Amber Nolan, David Okonkwo, Eva Palacios, Daniel Perl, Ava Puccio, Miri Rabinowitz, Claudia Robertson, Richard Ben Rodgers, Eric Rosenthal, Angelle Sander, Danielle Sandsmark, Andrea Schneider, David Schnyer, Seth Seabury, Mark Sherer, Gabriella Sugar, Nancy Temkin, Arthur Toga, Abel Torres-Espin, Alex Valadka, Mary Vassar, Kevin Wang, Vincent Wang, John K. Yue, Esther Yuh, Ross Zafonte

Publikováno v: EClinicalMedicine, Vol 78, Iss , Pp 102956- (2024)

Summary: Background: Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and

Externí odkaz: https://doaj.org/article/f0d8ef2d159d4becaeed193a67757155

Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI

Autor: Ramon Diaz-Arrastia, Thomas W. McAllister, Joel H. Kramer, Brandon Foreman, Alex B. Valadka, Dana Pisică, Sureyya Dikmen, Randall Merchant, Adam R. Ferguson, C. Dirk Keene, Raquel C. Gardner, Xiaoying Sun, Geoffrey T. Manley, Arthur W. Toga, Yelena G. Bodien, John D. Corrigan, Andrew I R Maas, Joseph T. Giacino, Christopher J. Madden, Pratik Mukherjee, Florence Noel, Claudia S. Robertson, Amber Nolan, Ross Zafonte, Murray B. Stein, Hester F. Lingsma, Nancy R. Temkin, Natalie Kreitzer, Opeolu Adeoye, J. Claude Hemphill, Rao P. Gullapalli, Kim Boase, Jan Verheyden, Luis Gonzalez, Laura B. Ngwenya, Christopher J. Lindsell, Miri Rabinowitz, Michael McCrea, Gillian Hotz, Jonathan Rosand, Shankar P. Gopinath, Harvey S. Levin, David M. Schnyer, Neeraj Badjatia, Ann-Christine Duhaime, Esther L. Yuh, Angelle M. Sander, Sabrina R Taylor, Étienne Gaudette, Eva M. Palacios, Gabriella Satris, Alastair J. Martin, David O. Okonkwo, Seth A. Seabury, Joan Machamer, Karen Crawford, Amy J. Markowitz, Richard G. Ellenbogen, V. Ramana Feeser, Lindsay D. Nelson, Mark Harris, Daniel P. Perl, Mary J. Vassar, Sonia Jain

Publikováno v: JAMA neurology, vol 78, iss 9
JAMA Neurology, 78(9), 1137-1148. American Medical Association
Dark, P 2021, ' Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. ', JAMA Neurology, vol. 78, no. 9, pp. 1137-1148 . https://doi.org/10.1001/jamaneurol.2021.2120
JAMA Neurology
Jama neurology, 78(9), 1137-1148. AMER MEDICAL ASSOC
JAMA neurology

Key Points Question Are different patterns of intracranial injury on head computed tomography associated with prognosis after mild traumatic brain injury (mTBI)? Findings In this cohort study, subarachnoid hemorrhage, subdural hematoma, and contusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d5d672acf41541db9bde1347d74156
https://escholarship.org/uc/item/5wz6r0h3

PCSK9 Inhibitors Show Value for Patients and the US Health Care System

Autor: W.H. Cheng, Dana P. Goldman, Étienne Gaudette

Publikováno v: Value in Health. 20:1270-1278

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors were approved by the US Food and Drug Administration (FDA) as cholesterol-lowering therapies for patients with familial hypercholesterolemia or atherosclerotic cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb8aaff4e1bf75c84099194acf5b054
https://doi.org/10.1016/j.jval.2017.05.014