Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Étienne, Jacques"'
Autor:
Antoine Champie, Jean-Christophe Lachance, Anand Sastry, Dominick Matteau, Colton J. Lloyd, Frédéric Grenier, Cameron R. Lamoureux, Simon Jeanneau, Adam M. Feist, Pierre-Étienne Jacques, Bernhard O. Palsson, Sébastien Rodrigue
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Microorganisms with simplified genomes represent interesting cell chassis for systems and synthetic biology. However, genome reduction can lead to undesired traits, such as decreased growth rate and metabolic imbalances. To investigate the i
Externí odkaz:
https://doaj.org/article/04a55e0de4eb4ac2a7d3e89e6f0be8fb
Autor:
Cécilia Légaré, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Andrée-Anne Clément, Cédrik Poirier, Zhong-Cheng Luo, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1285 (2024)
Maternal blood glucose regulation adaptation to pregnancy aims to support fetal growth but may also lead to the development of gestational diabetes mellitus, the most common pregnancy complication. MiRNAs are small RNA molecules secreted and stable i
Externí odkaz:
https://doaj.org/article/bae7fa08ebb749ce8117b867cffec14a
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 916-927 (2022)
Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms.
Externí odkaz:
https://doaj.org/article/5363415cc3e6442ca8e1e5ed6510e109
Autor:
Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs). These small non-co
Externí odkaz:
https://doaj.org/article/fcbd58a1d66b40708e2736977b1c3050
Enabling low-cost and robust essentiality studies with high-throughput transposon mutagenesis (HTTM)
Autor:
Antoine Champie, Amélie De Grandmaison, Simon Jeanneau, Frédéric Grenier, Pierre-Étienne Jacques, Sébastien Rodrigue
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Transposon-insertion sequencing (TIS) methods couple high density transposon mutagenesis with next-generation sequencing and are commonly used to identify essential or important genes in bacteria. However, this approach can be work-intensive and some
Externí odkaz:
https://doaj.org/article/f0cea8d18a6348a69e127b7d13a13d3f
Autor:
Cécilia Légaré, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Andrée-Anne Clément, Cédrik Poirier, Zhong Cheng Luo, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
AimsOur objective is to identify first-trimester plasmatic miRNAs associated with and predictive of GDM.MethodsWe quantified miRNA using next-generation sequencing in discovery (Gen3G: n = 443/GDM = 56) and replication (3D: n = 139/GDM = 76) cohorts.
Externí odkaz:
https://doaj.org/article/6260b3782221406cae3ddd41e9273784
Autor:
Jean‐Christophe Lachance, Dominick Matteau, Joëlle Brodeur, Colton J Lloyd, Nathan Mih, Zachary A King, Thomas F Knight, Adam M Feist, Jonathan M Monk, Bernhard O Palsson, Pierre‐Étienne Jacques, Sébastien Rodrigue
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 7, Pp 1-20 (2021)
Abstract Mesoplasma florum, a fast‐growing near‐minimal organism, is a compelling model to explore rational genome designs. Using sequence and structural homology, the set of metabolic functions its genome encodes was identified, allowing the rec
Externí odkaz:
https://doaj.org/article/ffd50eb1a2234bef84adfb826296e9f3
Autor:
Dominick Matteau, Jean‐Christophe Lachance, Frédéric Grenier, Samuel Gauthier, James M Daubenspeck, Kevin Dybvig, Daniel Garneau, Thomas F Knight, Pierre‐Étienne Jacques, Sébastien Rodrigue
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-25 (2020)
Abstract The near‐minimal bacterium Mesoplasma florum is an interesting model for synthetic genomics and systems biology due to its small genome (~ 800 kb), fast growth rate, and lack of pathogenic potential. However, fundamental aspects of its bio
Externí odkaz:
https://doaj.org/article/3774f6c6b32544339ba24881ef15941d
Autor:
L. Jonathan Dursi, Zoltan Bozoky, Richard de Borja, Haoyuan Li, David Bujold, Adam Lipski, Shaikh Farhan Rashid, Amanjeev Sethi, Neelam Memon, Dashaylan Naidoo, Felipe Coral-Sasso, Matthew Wong, P-O Quirion, Zhibin Lu, Samarth Agarwal, Yuriy Pavlov, Andrew Ponomarev, Mia Husic, Krista Pace, Samantha Palmer, Stephanie A. Grover, Sevan Hakgor, Lillian L. Siu, David Malkin, Carl Virtanen, Trevor J. Pugh, Pierre-Étienne Jacques, Yann Joly, Steven J.M. Jones, Guillaume Bourque, Michael Brudno
Publikováno v:
Cell Genomics, Vol 1, Iss 2, Pp 100033- (2021)
We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Alliance for Ge
Externí odkaz:
https://doaj.org/article/cb228eeaf5b24ef2bdf9cdff5b01b44c
Autor:
Kathrine Thibeault, Cécilia Légaré, Véronique Desgagné, Frédérique White, Andrée-Anne Clément, Michelle S. Scott, Pierre-Étienne Jacques, Renée Guérin, Patrice Perron, Marie-France Hivert, Luigi Bouchard
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1726 (2022)
Many women enter pregnancy with overweight and obesity, which are associated with complications for both the expectant mother and her child. MicroRNAs (miRNAs) are short non-coding RNAs that regulate many biological processes, including energy metabo
Externí odkaz:
https://doaj.org/article/99b2f5efb738465990a8314c22eb3e4b