Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Autor: José Luís Fachi, Jaqueline de Souza Felipe, Laís Passariello Pral, Bruna Karadi da Silva, Renan Oliveira Corrêa, Mirella Cristiny Pereira de Andrade, Denise Morais da Fonseca, Paulo José Basso, Niels Olsen Saraiva Câmara, Éricka Lorenna de Sales e Souza, Flaviano dos Santos Martins, Suzana Eiko Sato Guima, Andrew Maltez Thomas, João Carlos Setubal, Yuli Thamires Magalhães, Fábio Luis Forti, Thamiris Candreva, Hosana Gomes Rodrigues, Marcelo Bispo de Jesus, Sílvio Roberto Consonni, Alessandro dos Santos Farias, Patrick Varga-Weisz, Marco Aurélio Ramirez Vinolo

Publikováno v: Cell Reports, Vol 27, Iss 3, Pp 750-761.e7 (2019)

Summary: Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-ind

Externí odkaz: https://doaj.org/article/9c4fc043dfbe4f37bba8f567ccb37dd6

Beneficial effects resulting from oral administration of Escherichia coli Nissle 1917 on a chronic colitis model

Autor: Flaviano S. Martins, Vasco Azevedo, Gabriel Fernandes, Jacques Robert Nicoli, Diego Carlos dos Reis, Geovanni Dantas Cassali, Simone de Vasconcelos Generoso, Valbert Nascimento Cardoso, Éricka Lorenna de Sales e Souza, Julliane Dutra Medeiros, C L V Campos

Publikováno v: Beneficial Microbes. 11:779-790

Inflammatory bowel diseases (IBD) are chronic processes involving a deregulated immune response against intestinal microbiota in genetically susceptible individuals. Ulcerative colitis (UC) is an IBD restricted to colonic mucosa and its chronicity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1db25508c5708ce5ead028742aa81f9c
https://doi.org/10.3920/bm2020.0045

Intestinal toxicity evaluation of long-circulating and pH-sensitive liposomes loaded with cisplatin

Autor: Éricka Lorenna de Sales e Souza, Mônica Cristina de Oliveira, Rachel Freire, Diego Carlos dos Reis, Bruno R. C. Costa, Geovanni Dantas Cassali, Raquel Silva Araújo, Josianne Nicácio Silveira, Ana Letícia Malheiros Silveira, Valbert Nascimento Cardoso, Flaviano S. Martins, Adaliene Versiani Matos Ferreira, Jacqueline Isaura Alvarez Leite, Cristina Maria de Souza, Lirlândia P. Sousa, Michelle A. Sugimoto

Publikováno v: European Journal of Pharmaceutical Sciences. 106:142-151

Cisplatin (CDDP) is a chemotherapeutic agent widely used in several anticancer protocols for instance head and neck, testicle, ovarian, lung and peritoneal carcinomatosis. According to the literature, the use of CDDP is associated with several side e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed78fcf42448deca3ed6a38818d5bf0
https://doi.org/10.1016/j.ejps.2017.05.046

Cell Reports

Autor: Renan O. Corrêa, Laís Passariello Pral, Andrew Maltez Thomas, Yuli Thamires Magalhães, Niels Olsen Saraiva Câmara, Marcelo Bispo de Jesus, Mirella Cristiny Pereira de Andrade, Jaqueline de Souza Felipe, Éricka Lorenna de Sales e Souza, José Luís Fachi, Marco Aurélio Ramirez Vinolo, Suzana Eiko Sato Guima, Bruna Karadi da Silva, Alessandro S. Farias, Sílvio Roberto Consonni, Paulo José Basso, Hosana G. Rodrigues, Denise Morais da Fonseca, João C. Setubal, Fabio Luis Forti, Patrick Varga-Weisz, Flaviano S. Martins, Thamiris Candreva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell Reports, Vol 27, Iss 3, Pp 750-761.e7 (2019)

Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545730f63f5950e9a584ca55a88d962b

Escherichia coli strain Nissle 1917 ameliorates experimental colitis by modulating intestinal permeability, the inflammatory response and clinical signs in a faecal transplantation model

Autor: Jacques Robert Nicoli, Samir D.A. Elian, Mauro M. Teixeira, Angélica T. Vieira, Cristiana C. Garcia, Éricka Lorenna de Sales e Souza, Flaviano S. Martins, Laís M. Paula, Rosa Maria Esteves Arantes

Publikováno v: Journal of Medical Microbiology. 65:201-210

Inflammatory bowel diseases (IBDs) are a group of inflammatory conditions of the gut that include ulcerative colitis and Crohn's disease. Probiotics are live micro-organisms that may be used as adjuvant therapy for patients with IBD. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12add410b465a616a1d532ea2516a960
https://doi.org/10.1099/jmm.0.000222