Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Éric Quéméneur"'
Autor:
Cheyne Kurokawa, Sonia Agrawal, Abhisek Mitra, Elena Galvani, Shannon Burke, Ankita Varshine, Raymond Rothstein, Kevin Schifferli, Noel R. Monks, Johann Foloppe, Nathalie Silvestre, Eric Quemeneur, Christelle Demeusoit, Patricia Kleinpeter, Puja Sapra, Carl Barrett, Scott A. Hammond, Elizabeth J. Kelly, Jason Laliberte, Nicholas M. Durham, Michael Oberst, Maria A.S. Broggi
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200758- (2024)
Oncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to e
Externí odkaz:
https://doaj.org/article/451f421c29ac474f8695a5be66804ebc
Autor:
Jérémy Béguin, Matthias Kohlhauer, Eve Laloy, Frédérique Degorce, Baptiste Moreau, Éric Quéméneur, Philippe Erbs, Bernard Klonjkowski, Christelle Maurey
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-10 (2021)
Abstract Background 5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil durin
Externí odkaz:
https://doaj.org/article/ae675ea99449475ca5cc6404a9cd7b02
Autor:
Jérémy Béguin, Murielle Gantzer, Isabelle Farine, Johann Foloppe, Bernard Klonjkowski, Christelle Maurey, Éric Quéméneur, Philippe Erbs
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Oncolytic virotherapy is an emerging strategy that uses replication-competent viruses to kill tumor cells. We have reported the oncolytic effects of TG6002, a recombinant oncolytic vaccinia virus, in preclinical human xenograft models and ca
Externí odkaz:
https://doaj.org/article/68a68d93323c4c66a8300f3d5dd7b61e
Autor:
Laetitia Fend, Eric Quemeneur, Jean-Baptiste Marchand, Nathalie Silvestre, Johann Foloppe, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fadi Azar, Christelle Demeusoit, Clémentine Spring-Giusti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background TG6050 was designed as an improved oncolytic vector, combining the intrinsic properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted expression of recombinant immune effectors to modify the tumor immune ph
Externí odkaz:
https://doaj.org/article/51ec8ad7965d4c9fa9fa907be1c0686c
Autor:
Christophe A. Marquette, Emma Petiot, Anita Spindler, Caroline Ebel, Mael Nzepa, Baptiste Moreau, Philippe Erbs, Jean-Marc Balloul, Eric Quemeneur, Cécile Zaupa
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The oncolytic virus represents a promising therapeutic strategy involving the targeted replication of viruses to eliminate cancer cells, while preserving healthy ones. Despite ongoing clinical trials, this approach encounters significant challenges.
Externí odkaz:
https://doaj.org/article/df9a4d6ebb9243c9a85e820583cb7464
Autor:
Hélène Lê, Jules Deforges, Pasquale Cutolo, Anissa Lamarque, Guoqiang Hua, Véronique Lindner, Shreyansh Jain, Jean-Marc Balloul, Nadia Benkirane-Jessel, Eric Quéméneur
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Onco-virotherapy is an emergent treatment for cancer based on viral vectors. The therapeutic activity is based on two different mechanisms including tumor-specific oncolysis and immunostimulatory properties. In this study, we evaluated onco-virothera
Externí odkaz:
https://doaj.org/article/6c17b8192e2d4ef1ad592594a56141d4
Autor:
Jérémy Béguin, Eve Laloy, Sandrine Cochin, Murielle Gantzer, Isabelle Farine, Christelle Pichon, Baptiste Moreau, Johann Foloppe, Jean-Marc Balloul, Christelle Machon, Jérôme Guitton, Dominique Tierny, Bernard Klonjkowski, Eric Quéméneur, Christelle Maurey, Philippe Erbs
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 103-116 (2023)
TG6002 is an oncolytic vaccinia virus expressing FCU1 protein, which converts 5-fluorocytosine into 5-fluorouracil. The study objectives were to assess tolerance, viral replication, 5-fluorouracil synthesis, and tumor microenvironment modifications t
Externí odkaz:
https://doaj.org/article/158089590f2b4c318c0aec5c6f69e200
Autor:
Christelle Remy, Elodie Pintado, Marshall Dunlop, Shirley Schön, Patricia Kleinpeter, Homa Rozanes, Laetitia Fend, Renée Brandely, Michel Geist, Delphine Suhner, Eline Winter, Nathalie Silvestre, Claire Huguet, Peter Fitzgerald, Eric Quéméneur, Jean-Baptiste Marchand
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Arming oncolytic viruses with transgenes encoding immunomodulators improves their therapeutic efficacy by enhancing and/or sustaining the innate and adaptive anti-tumoral immune responses. We report here the isolation, selection, and vectorization of
Externí odkaz:
https://doaj.org/article/a67cca8ad25a4e0ea646c9801a9e9364
Autor:
Hélène Lê, Jules Deforges, Guoqiang Hua, Ysia Idoux-Gillet, Charlotte Ponté, Véronique Lindner, Anne Olland, Pierre-Emanuel Falcoz, Cécile Zaupa, Shreyansh Jain, Eric Quéméneur, Nadia Benkirane-Jessel, Jean-Marc Balloul
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108094- (2023)
Summary: This work describes a patient-derived tumoroid model (PDTs) to support precision medicine in lung oncology. The use of human adipose tissue-derived microvasculature and patient-derived peripheral blood mononuclear cells (PBMCs) permits to ac
Externí odkaz:
https://doaj.org/article/f04495021d784eabb48ecdf7bddeee29
Autor:
Anasse Nounsi, Joseph Seitlinger, Charlotte Ponté, Julien Demiselle, Ysia Idoux-Gillet, Erwan Pencreach, Michèle Beau-Faller, Véronique Lindner, Jean-Marc Balloul, Eric Quemeneur, Hélène Burckel, Georges Noël, Anne Olland, Florence Fioretti, Pierre-Emmanuel Falcoz, Nadia Benkirane-Jessel, Guoqiang Hua
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1824 (2023)
Radiation therapy and platinum-based chemotherapy are common treatments for lung cancer patients. Several factors are considered for the low overall survival rate of lung cancer, such as the patient’s physical state and the complex heterogeneity of
Externí odkaz:
https://doaj.org/article/dbd8ffc5895445ddb7df859cf885a4d9