Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Élie Besserer-Offroy"'
Autor:
Élora Midavaine, Rebecca L. Brouillette, Elizabeth Théberge, Christine E. Mona, Sakeen W. Kashem, Jérôme Côté, Vera Zeugin, Élie Besserer-Offroy, Jean-Michel Longpré, Éric Marsault, Philippe Sarret
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107242- (2024)
Targeting the CCL2/CCR2 chemokine axis has been shown to be effective at relieving pain in rodent models of inflammatory and neuropathic pain, therefore representing a promising avenue for the development of non-opioid analgesics. However, clinical t
Externí odkaz:
https://doaj.org/article/a3c6c0bcb1794b82b01f8cb0c9ec8707
Autor:
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective ant
Externí odkaz:
https://doaj.org/article/718b186632fa46f2ad43c9c7ad152fa9
Autor:
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonis
Externí odkaz:
https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
Autor:
Chahrazed Boulkeroua, Houda Ayari, Taoufik Khalfaoui, Mylène Lafrance, Élie Besserer-Offroy, Nadia Ekindi, Robert Sabbagh, Robert Dumaine, Olivier Lesur, Philippe Sarret, Ahmed Chraibi
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 687-700 (2019)
Externí odkaz:
https://doaj.org/article/cfbc7d650ae145beaf580d28ffe8605f
Autor:
Cécile Pétigny, Audrey-Ann Dumont, Hugo Giguère, Audrey Collette, Brian J. Holleran, Mircea Iftinca, Christophe Altier, Élie Besserer-Offroy, Mannix Auger-Messier, Richard Leduc
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2502 (2022)
Transient receptor potential canonical (TRPC) channels are membrane proteins involved in regulating Ca2+ homeostasis, and whose functions are modulated by G protein-coupled receptors (GPCR). In this study, we developed bioluminescent resonance energy
Externí odkaz:
https://doaj.org/article/c9c382d84c8f46af9f4d22b75914d4b0
Autor:
Élie Besserer-Offroy, Pascal Tétreault, Rebecca L Brouillette, Adeline René, Alexandre Murza, Roberto Fanelli, Karyn Kirby, Alexandre Parent, Isabelle Dubuc, Nicolas Beaudet, Jérôme Côté, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105884- (2020)
Neurotensin (NT) is a tridecapeptide displaying interesting antinociceptive properties through its action on its receptors, NTS1 and NTS2. Neurotensin-like compounds have been shown to exert better antinociceptive properties than morphine at equimola
Externí odkaz:
https://doaj.org/article/7e1f54a7e3e54f5d8d076d1b38926432
Autor:
Arman A. Sadybekov, Rebecca L. Brouillette, Egor Marin, Anastasiia V. Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1634 (2020)
Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely use
Externí odkaz:
https://doaj.org/article/f10a2b76089f4d51a6bf3e664058debc
Autor:
Kien Tran, Xavier Sainsily, Jérôme Côté, David Coquerel, Pierre Couvineau, Sabrina Saibi, Lounès Haroune, Élie Besserer-Offroy, Joël Flynn-Robitaille, Martin Resua Rojas, Alexandre Murza, Jean-Michel Longpré, Mannix Auger-Messier, Olivier Lesur, Michel Bouvier, Éric Marsault, Pierre-Luc Boudreault, Philippe Sarret
Publikováno v:
Journal of Medicinal Chemistry. 65:531-551
Autor:
Vadim Cherezov, Gye Won Han, Anastasiia Sadybekov, Nairie Michaelian, Stephen M. Soisson, Jeremy Presland, Élie Besserer-Offroy, Xavier Fradera, Philippe Sarret, Vsevolod Katritch, Kerrie Spencer, Phieng Siliphaivanh, Beata Zamlynny, Petr Popov, Harini Krishnamurthy
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The leukotriene B4 receptor 1 (BLT1) regulates the recruitment and chemotaxis of different cell types and plays a role in the pathophysiology of infectious, allergic, metabolic, and tumorigenic human diseases. Here we present a crystal structure of h
Autor:
Robert Dumaine, Olivier Lesur, Nadia Ekindi, Robert Sabbagh, Chahrazed Boulkeroua, Philippe Sarret, Ahmed Chraibi, Taoufik Khalfaoui, Élie Besserer-Offroy, Mylène Lafrance, Houda Ayari
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 687-700 (2019)
Background/aims Apelin and its G protein-coupled receptor APJ (gene symbol Aplnr) are strongly expressed in magnocellular vasopressinergic neurons suggesting that the apelin/APJ system plays a key role at the central level in regulating salt and wate