Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Éamon Hughes"'
Autor:
Karoline Berger, Sara Rhost, Svanheiður Rafnsdóttir, Éamon Hughes, Ylva Magnusson, Maria Ekholm, Olle Stål, Lisa Rydén, Göran Landberg
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in s
Externí odkaz:
https://doaj.org/article/86319f48f2eb40659a4d1bba84730216
Autor:
Hanna Jacobsson, Hannah Harrison, Éamon Hughes, Emma Persson, Sara Rhost, Paul Fitzpatrick, Anna Gustafsson, Daniel Andersson, Pernilla Gregersson, Ylva Magnusson, Anders Ståhlberg, Göran Landberg
Publikováno v:
Molecular Oncology, Vol 13, Iss 8, Pp 1693-1705 (2019)
It is well known that tumour cells are dependent on communication with the tumour microenvironment. Previously, it has been shown that hypoxia (HX) induces pronounced, diverse and direct effects on cancer stem cell (CSC) qualities in different breast
Externí odkaz:
https://doaj.org/article/ddc08bd9fdd54c31affa57a9759a765d
Autor:
Sara Rhost, Éamon Hughes, Hannah Harrison, Svanheidur Rafnsdottir, Hanna Jacobsson, Pernilla Gregersson, Ylva Magnusson, Paul Fitzpatrick, Daniel Andersson, Karoline Berger, Anders Ståhlberg, Göran Landberg
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within a tumour. Direct interactions between various cell types as well as ce
Externí odkaz:
https://doaj.org/article/28243b3ff06d406886043ba56c891b21
Autor:
Sara Charmsaz, Éamon Hughes, Fiona T. Bane, Paul Tibbitts, Marie McIlroy, Christopher Byrne, Sinéad Cocchiglia, Jean McBryan, Bryan T. Hennessy, Róisín M. Dwyer, Michael J. Kerin, Arnold D. Hill, Leonie S. Young
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and inhibition of its si
Externí odkaz:
https://doaj.org/article/9038e261bbdf458cab6fb650bd3a2722
Autor:
Hanna Jacobsson, Paul A. Fitzpatrick, Göran Landberg, Karoline Berger, Svanheidur Rafnsdottir, Sara Rhost, Éamon Hughes, Ylva Magnusson, Pernilla Gregersson, Hannah Harrison, Daniel Andersson, Anders Ståhlberg
Publikováno v:
Cancer Research. 79:P2-06
Background: A major challenge concerning breast cancer therapy is the occasional lack of effects using drugs that target cancer cells unspecifically. One possible explanation for this treatment failure is the existence of the small subpopulation of b
Autor:
Berger, Karoline, Rhost, Sara, Svanheiður Rafnsdóttir, Éamon Hughes, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran
Additional file 1:. REMARK guidelines. Checklist with REporting recommendations for tumor MARKer prognostic studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04de98e68707b2f64a71eebb694df96f
Autor:
Berger, Karoline, Rhost, Sara, Svanheiður Rafnsdóttir, Éamon Hughes, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran
Additional file 5: Supplementary material. Fig. S1: CONSORT diagram for the study. Flowchart of the study showing the enrollment of the patients, treatment allocation and analysis. Fig. S2: ERα positive patients stratified by treatment arm. Kaplan-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0906a301df2f56c9a8f515e6b67c477a
Autor:
Berger, Karoline, Rhost, Sara, Svanheiður Rafnsdóttir, Éamon Hughes, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran
Additional file 3:. Sortilin antibody validation. Validation of the sortilin antibody (ab16640, Abcam) using Western blotting and immunohistochemistry. Weak or no staining was seen in MCF10a and CAL-120, while strong positive staining was seen in T47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d900a6a1e4ebc86399da9756a7b7d7c4
Autor:
Berger, Karoline, Rhost, Sara, Svanheiður Rafnsdóttir, Éamon Hughes, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran
Additional file 6. Sortilin tumor expression on its own shows no difference in survival. Kaplan-Meier curves illustrating breast cancer-specific survival according to high or low sortilin expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cff05ec1cbe822f8f264c20e773514
Autor:
Berger, Karoline, Rhost, Sara, Svanheiður Rafnsdóttir, Éamon Hughes, Magnusson, Ylva, Ekholm, Maria, Stål, Olle, Rydén, Lisa, Landberg, Göran
Additional file 2:. Progranulin antibody validation. Validation of the progranulin antibody (AF2420, R&D Systems) using Western blotting and immunohistochemistry. Weak or no staining was seen in MCF10a and MDA-MB-468, while strong positive staining w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d1ecc4870a73013e191cae8ff83720