Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Çagatay Günes"'
Autor:
Michael Karl Melzer, Yanchun Ma, Jessica Lindenmayer, Clara Morgenstern, Felix Wezel, Friedemann Zengerling, Cagatay Günes, Nadine Therese Gaisa, Alexander Kleger, Christian Bolenz
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-7 (2024)
Abstract Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs) emerged as a novel too
Externí odkaz:
https://doaj.org/article/cfc496e6e02e4966b81c02bc4a642b0d
Autor:
Junnan Liu, Xue Wang, Wencheng Jiang, Anca Azoitei, Tim Eiseler, Markus Eckstein, Arndt Hartmann, Stephan Stilgenbauer, Mohamed Elati, Meike Hohwieler, Alexander Kleger, Axel John, Felix Wezel, Friedemann Zengerling, Christian Bolenz, Cagatay Günes
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-29 (2024)
Abstract Background We have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human and murine cells and accelerates cell transformation as well as tumor formation in xenogra
Externí odkaz:
https://doaj.org/article/f3dd2d1ae1494471a8095c3f91f82dd1
Autor:
Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold, Dharini Srinivasan, Ingo Burtscher, Chantal Allgöwer, Medhanie Mulaw, Friedemann Zengerling, Cagatay Günes, Heiko Lickert, Vincent M. Christoffels, Stefan Liebau, Martin Wagner, Thomas Seufferlein, Christian Bolenz, Anne M. Moon, Lukas Perkhofer, Alexander Kleger
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box family of transcription factors previously shown to regulate pluripot
Externí odkaz:
https://doaj.org/article/d01ac3b5e56244e18b99989bd1a98642
Autor:
Michael Karl Melzer, Markus Breunig, Paul Lopatta, Meike Hohwieler, Sarah Merz, Anca Azoitei, Cagatay Günes, Christian Bolenz, Alexander Kleger
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101869- (2022)
Summary: Ex vivo organ culture can be a useful alternative to in vivo models, which can be time-, labor-, and cost-intensive. Here we describe a step-by-step protocol to use de-epithelialized porcine urinary bladders as scaffolds in air-liquid interf
Externí odkaz:
https://doaj.org/article/5d8b4b8b8dd04c908cf9b27759361b14
Publikováno v:
Molecular Microbiology. 20:375-384
Summary The α-centred trp operator binds one dimer of the Trp repressor, whereas the β-centred trp operator binds two dimers of the Trp repressor (Carey et al., 1991; Haran et al., 1992). The Trp repressor with a Tyr-Gly-7 substitution binds almost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c148285d5e6007fb5fd50f22ddff37e
https://doi.org/10.1111/j.1365-2958.1996.tb02624.x
https://doi.org/10.1111/j.1365-2958.1996.tb02624.x
Autor:
Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and nonalcoholic fatty liver disease (FLD). The pathophysiological correlate is the massive production of reactive oxygen species. The role of CYP2E1 in the developm
Externí odkaz:
https://doaj.org/article/e74a70f467514028b4d33139a1dbe072
Autor:
Torsten Diesinger, Vyacheslav Buko, Alfred Lautwein, Radovan Dvorsky, Elena Belonovskaya, Oksana Lukivskaya, Elena Naruta, Siarhei Kirko, Viktor Andreev, Dominik Buckert, Sebastian Bergler, Christian Renz, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Berthold Büchele, Thomas Simmet, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235990 (2020)
Background and aimsAlcoholic steatohepatitis (ASH)-the inflammation of fatty liver-is caused by chronic alcohol consumption and represents one of the leading chronic liver diseases in Western Countries. ASH can lead to organ dysfunction or progress t
Externí odkaz:
https://doaj.org/article/67889073cb194f45b24f6833841d8c81
Autor:
Heidrun Hirner, Cagatay Günes, Joachim Bischof, Sonja Wolff, Arnhild Grothey, Marion Kühl, Franz Oswald, Florian Wegwitz, Michael R Bösl, Anna Trauzold, Doris Henne-Bruns, Christian Peifer, Frank Leithäuser, Wolfgang Deppert, Uwe Knippschild
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29709 (2012)
Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transf
Externí odkaz:
https://doaj.org/article/6c146078ced546758b3690d263e2f982