Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Åsmund T. Røe"'
Autor:
Peter P. Jones, Gustavo Jose Justo da Silva, Einar Sjaastad Norden, Lars Gullestad, Emil K. S. Espe, Ornella Manfra, Fouad A. Zouein, Åsmund T. Røe, Ida G. Lunde, Isabelle van Hout, Michael Frisk, Xin Shen, Yufeng Hou, Christopher Le, Martin Laasmaa, Sean Coffey, Christen P. Dahl, Raffaele Altara, Theis Tønnessen, Alessandro Cataliotti, Ivar Sjaastad, Regis R. Lambert, William E. Louch, J. Magnus Aronsen
Publikováno v:
Journal of the American College of Cardiology
Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with ventricular dilation and markedly reduced systolic function, heart failure with preserved ejection fraction (HFpEF) patients exhibit concentric hypertrophy and
Autor:
Ivar Sjaastad, Jan Magnus Aronsen, Steven A. Niederer, Sara Gattoni, William E. Louch, Åsmund T. Røe, Nicolas P. Smith
Publikováno v:
The Journal of Physiology. 595:3867-3889
Key points At the cellular level cardiac hypertrophy causes remodelling, leading to changes in ionic channel, pump and exchanger densities and kinetics. Previous studies have focused on quantifying changes in channels, pumps and exchangers without qu
Autor:
William E. Louch, Åsmund T. Røe, Steven A. Niederer, Michael Frisk, Nicolas P. Smith, Sara Gattoni
Publikováno v:
The Journal of Physiology. 594:4193-4224
KEY POINTS In the majority of species, including humans, increased heart rate increases cardiac contractility. This change is known as the force-frequency response (FFR). The majority of mammals have a positive force-frequency relationship (FFR). In
Autor:
Ida G. Lunde, Ivar Sjaastad, William E. Louch, Yufeng Hou, Christopher Le, Theis Tønnessen, Michael Frisk, Lars Gullestad, Ole M. Sejersted, Åsmund T. Røe, Xin Shen, Christen P. Dahl, Peter P. Jones
Publikováno v:
Journal of Molecular and Cellular Cardiology. 140:26
Autor:
Ivar Sjaastad, Terje R Selnes Kolstad, Geir Christensen, Stefano Longobardi, Jan Magnus Aronsen, Steven A. Niederer, Åsmund T. Røe, William E. Louch, Einar Sjaastad Norden, Ole M. Sejersted, Emil K. S. Espe, Ornella Manfra, Trygve Husebye, Geir Øystein Andersen, Alessandro Cataliotti, Marianne Ruud
Publikováno v:
Cardiovascular Research
Aims Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d59907ca030a5f482cc1ce5e490cea4
http://hdl.handle.net/10852/67924
http://hdl.handle.net/10852/67924
Publikováno v:
Current Pharmaceutical Design. 21:431-448
Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca(2+) homeostasis is recognized as a major contributor to the heart failure phe
Autor:
Markus B. Sikkel, Sian E. Harding, Alexander R. Lyon, Matthew H. Tranter, William E. Louch, Åsmund T. Røe, Jan Magnus Aronsen, Steven A. Niederer, Sander Land, Nicolas P. Smith, Daniel J. Stuckey
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
In Takotsubo cardiomyopathy, the left ventricle shows apical ballooning combined with basal hypercontractility. Both clinical observations in humans and recent experimental work on isolated rat ventricular myocytes suggest the dominant mechanisms of
Publikováno v:
Tidsskrift for Den norske legeforening.
Background Half of all heart failure patients have preserved ejection fraction, but there is no established therapy for this patient group. Effective heart failure therapy depends on an understanding of the underlying pathophysiology. This article pr
Autor:
Leiv Øyehaug, Åsmund T. Røe, Ole M. Sejersted, Kristian O. Loose, Geir Christensen, William E. Louch, Ivar Sjaastad, Guro F. Jølle
Publikováno v:
Biophysical Journal. 104(8):1685-1697
Recent work has demonstrated that cardiomyocyte Ca(2+)release is desynchronized in several pathological conditions. Loss of Ca(2+) release synchrony has been attributed to t-tubule disruption, but it is unknown if other factors also contribute. We in
Autor:
Michael Frisk, Ivar Sjaastad, Åsmund T. Røe, Per Andreas Norseng, Marianne Ruud, Emil K. S. Espe, William E. Louch, Geir Christensen, Ole M. Sejersted, Jan Magnus Aronsen, Lili Zhang
Publikováno v:
Cardiovascular Research
Aims Invaginations of the cellular membrane called t-tubules are essential for maintaining efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule structure during heart failure has been linked to dyssynchron