Výsledky vyhledávání - "Åsa Makower"

Akademický článek

Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome

Autor: Natalie M. Hendrikse, Anna Sandegren, Tommy Andersson, Jenny Blomqvist, Åsa Makower, Dominik Possner, Chao Su, Niklas Thalén, Agneta Tjernberg, Ulrica Westermark, Johan Rockberg, Stefan Svensson Gelius, Per-Olof Syrén, Erik Nordling

Publikováno v: iScience, Vol 24, Iss 3, Pp 102154- (2021)

Summary: We show the successful application of ancestral sequence reconstruction to enhance the activity of iduronate-2-sulfatase (IDS), thereby increasing its therapeutic potential for the treatment of Hunter syndrome—a lysosomal storage disease c

Externí odkaz: https://doaj.org/article/d39df5cce7224dbcaf4d0e1329c50468

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Akademický článek

Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice

Autor: Susanne Gustavsson, Elisabet Ohlin Sjöström, Agneta Tjernberg, Juliette Janson, Ulrica Westermark, Tommy Andersson, Åsa Makower, Erik Arnelöf, Gudrun Andersson, Jan Svartengren, Carina Ekholm, Stefan Svensson Gelius

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 21, Iss , Pp - (2019)

Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder (LSD) characterized by severe central nervous system (CNS) degeneration. The disease is caused by mutations in the SGSH gene coding for the lysosomal enzyme sulfamidase. Sulfa

Externí odkaz: https://doaj.org/article/5c5925a40eaf4e558c81d318fcb0dd0e

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Robust LC–MS/MS methods for analysis of heparan sulfate levels in CSF and brain for application in studies of MPS IIIA

Autor: Åsa Makower, Susanne Gustavsson, Agneta Tjernberg, Stefan Svensson Gelius, Tommy Andersson, Juliette Janson, Erik Arnelöf, Per-Olof Edlund

Publikováno v: Bioanalysis. 11:1389-1403

Aim: Accumulation of heparan sulfate (HS) is associated with the neurodegenerative disorder Mucopolysaccharidosis type IIIA (MPS IIIA). Here, we compare HS levels in brain and cerebrospinal fluid (CSF) of MPS IIIA mice after treatment with a chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790915dc4edc60537bef2b2a22010228
https://doi.org/10.4155/bio-2019-0095

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Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome

Autor: Åsa Makower, Anna Sandegren, Per-Olof Syrén, Stefan Svensson Gelius, Chao Su, Natalie M. Hendrikse, Dominik Possner, Agneta Tjernberg, Tommy Andersson, Niklas Thalén, Johan Rockberg, Jenny Blomqvist, Erik Nordling, Ulrica Westermark

Publikováno v: iScience
iScience, Vol 24, Iss 3, Pp 102154-(2021)

Summary We show the successful application of ancestral sequence reconstruction to enhance the activity of iduronate-2-sulfatase (IDS), thereby increasing its therapeutic potential for the treatment of Hunter syndrome—a lysosomal storage disease ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ad3569567e2a01fb80b9efb75d0c61
http://europepmc.org/articles/PMC7907806

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Improved identification of host cell proteins in a protein biopharmaceutical by LC-MS/MS using the ProteoMiner™ Enrichment Kit

Autor: Agneta Tjernberg, Åsa Makower, Harriet Mörtstedt, Per-Olof Edlund, Katarina Sjöberg

Publikováno v: Journal of pharmaceutical and biomedical analysis. 185

Host cell proteins (HCPs) in biotherapeutics can be identified by the use of enzymatic digestion and LC–MS/MS analysis. However, the major challenge is that HCPs are often present at very low levels in relation to the protein drug (low ppm-levels).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc19ad002ba9a6c28476f879d7b7bab
https://pubmed.ncbi.nlm.nih.gov/32229402

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