Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Åsa K, Björklund"'
Autor:
Ammar Zaghlool, Adnan Niazi, Åsa K. Björklund, Jakub Orzechowski Westholm, Adam Ameur, Lars Feuk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Transcriptome analysis has mainly relied on analyzing RNA sequencing data from whole cells, overlooking the impact of subcellular RNA localization and its influence on our understanding of gene function, and interpretation of gene expression
Externí odkaz:
https://doaj.org/article/9a91b169ba164e37b3d0b15f348a8368
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-
Externí odkaz:
https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
Autor:
Joanna Hård, Ezeddin Al Hakim, Marie Kindblom, Åsa K. Björklund, Bengt Sennblad, Ilke Demirci, Marta Paterlini, Pedro Reu, Erik Borgström, Patrik L. Ståhl, Jakob Michaelsson, Jeff E. Mold, Jonas Frisén
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Accurate variant calling and genotyping represent major limiting factors for downstream applications of single-cell genomics. Here, we report Conbase for the identification of somatic mutations in single-cell DNA sequencing data. Conbase lev
Externí odkaz:
https://doaj.org/article/d7256999290e4f278690007945966f0b
Autor:
Katarína Tiklová, Åsa K. Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M. Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neuron
Externí odkaz:
https://doaj.org/article/fb22d9e2478a422ebc121e8f033474f4
Autor:
Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K. Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serot
Externí odkaz:
https://doaj.org/article/6df7c45a61984546bf5cda6b2f25f8ed
Autor:
Medya Mara Shikhagaie, Åsa K. Björklund, Jenny Mjösberg, Jonas S. Erjefält, Anne S. Cornelissen, Xavier Romero Ros, Suzanne M. Bal, Jasper J. Koning, Reina E. Mebius, Michiko Mori, Melanie Bruchard, Bianca Blom, Hergen Spits
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1761-1773 (2017)
Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity.
Externí odkaz:
https://doaj.org/article/aa25019afd43430bba29f05387ad8fb5
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/07caa5d96c2949738e0c1d2aeb44e50d
Autor:
Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K. Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support to Thomas Perlmann provided by Knut and Alice Wallenberg Foundation
Externí odkaz:
https://doaj.org/article/89cfe751352c4056992547d84031ebc5
Autor:
Tina Sarén, Mohanraj Ramachandran, Gustav Gammelgård, Tanja Lövgren, Kristina Wikström, Jamileh Hashemi, Eva Freyhult, Claudio Mirabello, Åsa K Björklund, Håkan Ahlström, Rose-Marie Amini, Hans Hagberg, Angelica Loskog, Gunilla Enblad, Magnus Essand
Publikováno v:
Cancer Research. 83:1793-1793
Although CD19-targeting CAR T cell therapy has shown remarkable success against B cell malignancies there is still room for improvement. To improve long-term responses amongst lymphoma patients, mechanisms underlying initial response and tumor relaps
Autor:
Cheng, Zhao, Savana, Biondic, Katherine, Vandal, Åsa K, Björklund, Michael, Hagemann-Jensen, Theresa Maria, Sommer, Jesica, Canizo, Stephen, Clark, Pascal, Raymond, Daniel R, Zenklusen, Nicolas, Rivron, Wolf, Reik, Sophie, Petropoulos
Publikováno v:
Genome research.
The preconceptual, intrauterine, and early life environments can have a profound and long-lasting impact on the developmental trajectories and health outcomes of the offspring. Given the relatively low success rates of assisted reproductive technolog