Zobrazeno 1 - 10 of 213 pro vyhledávání: '"Ávila-Nieto C"'
1
Akademický článek
Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Autor: Gualdrón-López M; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Ayllon-Hermida A; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Cortes-Serra N; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Resa-Infante P; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Bech-Serra JJ; Josep Carreras Leukemia Research Institute, Badalona, Spain., Aparici-Herraiz I; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Nicolau-Fernandez M; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Erkizia I; IrsiCaixa, Badalona, Spain., Gutierrez-Chamorro L; IrsiCaixa, Badalona, Spain., Marfil S; IrsiCaixa, Badalona, Spain., Pradenas E; IrsiCaixa, Badalona, Spain., Ávila Nieto C; IrsiCaixa, Badalona, Spain., Cucurull B; Josep Carreras Leukemia Research Institute, Badalona, Spain., Montaner-Tarbés S; Innovex Therapeutics S.L., Badalona, Spain., Muelas M; International Health Service, Hospital Clínic, Barcelona, Spain., Sotil R; International Health Service, Hospital Clínic, Barcelona, Spain., Ballana E; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Urrea V; IrsiCaixa, Badalona, Spain., Fraile L; Agro tecnio Center, Department of Animal Science, University of Lleida, Lleida, Spain., Montoya M; Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain., Vergara J; Unitat Mixta d'Investigació Institute of Agrifood Research and Technology UAB (IRTA-UAB) en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spain.; Institute of Agrifood Research and Technology (IRTA) Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spain., Segales J; Unitat Mixta d'Investigació Institute of Agrifood Research and Technology UAB (IRTA-UAB) en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Bellaterra, Spain., Carrillo J; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Izquierdo-Useros N; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Blanco J; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Fernandez-Becerra C; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., de La Torre C; Josep Carreras Leukemia Research Institute, Badalona, Spain., Pinazo MJ; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Martinez-Picado J; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; IrsiCaixa, Badalona, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Del Portillo HA; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Nov 06; Vol. 14, pp. 1442743. Date of Electronic Publication: 2024 Nov 06 (Print Publication: 2024).
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3
Akademický článek
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4
Akademický článek
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5
Akademický článek
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant.
Autor: Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Badalona, Spain., Vergara-Alert J; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Amengual-Rigo P; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Ainsua-Enrich E; IrsiCaixa AIDS Research Institute, Badalona, Spain., Brustolin M; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Rodríguez de la Concepción ML; IrsiCaixa AIDS Research Institute, Badalona, Spain., Pedreño-Lopez N; IrsiCaixa AIDS Research Institute, Badalona, Spain., Rodon J; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Urrea V; IrsiCaixa AIDS Research Institute, Badalona, Spain., Pradenas E; IrsiCaixa AIDS Research Institute, Badalona, Spain., Marfil S; IrsiCaixa AIDS Research Institute, Badalona, Spain., Ballana E; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Riveira-Muñoz E; IrsiCaixa AIDS Research Institute, Badalona, Spain., Pérez M; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Roca N; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Tarrés-Freixas F; IrsiCaixa AIDS Research Institute, Badalona, Spain., Carabelli J; IrsiCaixa AIDS Research Institute, Badalona, Spain., Cantero G; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; IRTA Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Pons-Grífols A; IrsiCaixa AIDS Research Institute, Badalona, Spain., Rovirosa C; IrsiCaixa AIDS Research Institute, Badalona, Spain., Aguilar-Gurrieri C; IrsiCaixa AIDS Research Institute, Badalona, Spain., Ortiz R; IrsiCaixa AIDS Research Institute, Badalona, Spain., Barajas A; IrsiCaixa AIDS Research Institute, Badalona, Spain., Trinité B; IrsiCaixa AIDS Research Institute, Badalona, Spain., Lepore R; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain., Muñoz-Basagoiti J; IrsiCaixa AIDS Research Institute, Badalona, Spain., Perez-Zsolt D; IrsiCaixa AIDS Research Institute, Badalona, Spain., Izquierdo-Useros N; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Valencia A; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Blanco J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic - Central University of Catalonia (UVic - UCC), Vic, Spain., Clotet B; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic - Central University of Catalonia (UVic - UCC), Vic, Spain.; Fundació Lluita contra les Infeccions, Hospital Germans Trias i Pujol, Badalona, Spain., Guallar V; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Segalés J; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, Cerdanyola del Vallès, Spain., Carrillo J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Publikováno v: Frontiers in immunology [Front Immunol] 2023 Dec 04; Vol. 14, pp. 1291972. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2023).
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6
Periodical
The first year of young group of the Spanish Immunology Society: Progress, challenges, and next steps.
Autor: Cela C; Immune System Development and Function Unit, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain., Roa-Bautista A; Marques de Valdecilla University Hospital, Santander, Spain., Méndez-Pérez A; Department of Molecular & Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Germans Trias I Pujol Research Institute (IGTP), Can Ruti Campus, Badalona, Spain., Garcia-Calvo E; Nutrition and Food Science Department School of Veterinary Medicine Complutense, Universidad Complutense de Madrid, Madrid, Spain., Hernández-García E; Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Publikováno v: European journal of immunology [Eur J Immunol] 2023 May; Vol. 53 (5), pp. e2350491. Date of Electronic Publication: 2023 Apr 28.
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7
Akademický článek
An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses.
Autor: Tarrés-Freixas F; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Aguilar-Gurrieri C; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Rodríguez de la Concepción ML; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Urrea V; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Trinité B; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Ortiz R; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Pradenas E; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Blanco P; Comparative Medicine and Bioimage Centre of Catalonia (CMCiB), Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Marfil S; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Molinos-Albert LM; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain.; ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain., Barajas A; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Pons-Grífols A; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Varela I; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain., Cervera L; Grup d'Enginyeria Cel•lular i Bioprocessos, Department of Chemical, Biological and Environmental Engineering, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08913, Cerdanyola del Vallès, Catalonia, Spain., Gutiérrez-Granados S; Grup d'Enginyeria Cel•lular i Bioprocessos, Department of Chemical, Biological and Environmental Engineering, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08913, Cerdanyola del Vallès, Catalonia, Spain., Segura MM; Grup d'Enginyeria Cel•lular i Bioprocessos, Department of Chemical, Biological and Environmental Engineering, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08913, Cerdanyola del Vallès, Catalonia, Spain., Gòdia F; Grup d'Enginyeria Cel•lular i Bioprocessos, Department of Chemical, Biological and Environmental Engineering, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08913, Cerdanyola del Vallès, Catalonia, Spain., Clotet B; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Barcelona, Spain., Carrillo J; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain. jcarrillo@irsicaixa.es.; Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Badalona, 08916, Barcelona, Spain. jcarrillo@irsicaixa.es.; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. jcarrillo@irsicaixa.es., Blanco J; IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916, Badalona, Catalonia, Spain. jblanco@irsicaixa.es.; University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Barcelona, Spain. jblanco@irsicaixa.es.; Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Badalona, 08916, Barcelona, Spain. jblanco@irsicaixa.es.; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. jblanco@irsicaixa.es.
Publikováno v: NPJ vaccines [NPJ Vaccines] 2023 Apr 06; Vol. 8 (1), pp. 51. Date of Electronic Publication: 2023 Apr 06.
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Akademický článek
Syphilis vaccine: challenges, controversies and opportunities.
Autor: Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Autonomous University of Barcelona, Cerdanyola del Vallès, Catalonia, Spain., Pedreño-López N; IrsiCaixa AIDS Research Institute, Badalona, Spain., Mitjà O; Skin Neglected Tropical Diseases and Sexually Transmitted Infections Department, Germans Trias i Pujol Hospital, Badalona, Spain.; Fight Infections Foundation, Germans Trias i Pujol Hospital, Badalona, Catalonia, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic - Central University of Catalonia (UVic - UCC), Vic, Catalonia, Spain., Clotet B; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Fight Infections Foundation, Germans Trias i Pujol Hospital, Badalona, Catalonia, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic - Central University of Catalonia (UVic - UCC), Vic, Catalonia, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBERINFEC, Instituto de Salut Carlos III (ISCIII), Madrid, Spain., Blanco J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic - Central University of Catalonia (UVic - UCC), Vic, Catalonia, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBERINFEC, Instituto de Salut Carlos III (ISCIII), Madrid, Spain., Carrillo J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; CIBERINFEC, Instituto de Salut Carlos III (ISCIII), Madrid, Spain.
Publikováno v: Frontiers in immunology [Front Immunol] 2023 Apr 06; Vol. 14, pp. 1126170. Date of Electronic Publication: 2023 Apr 06 (Print Publication: 2023).
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9
Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunity
Autor: Carrillo J, Izquierdo-Useros N, Ávila-Nieto C, Pradenas E, Clotet B, Blanco J
Publikováno v: Biochemical and Biophysical Research Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
The magnitude and the quality of humoral responses against SARS-CoV-2 have been associated with clinical outcome. Although the elicitation of humoral responses against different viral proteins is rapid and occurs in most infected individuals, its mag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22b3acec446cc5bf5befe0e348dacf98
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1406
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10
Akademický článek
Comparison of Reverse Transcription (RT)-Quantitative PCR and RT-Droplet Digital PCR for Detection of Genomic and Subgenomic SARS-CoV-2 RNA.
Autor: Morón-López S; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain., Riveira-Muñoz E; IrsiCaixa AIDS Research Institute, Badalona, Spain., Urrea V; IrsiCaixa AIDS Research Institute, Badalona, Spain., Gutiérrez-Chamorro L; IrsiCaixa AIDS Research Institute, Badalona, Spain., Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Badalona, Spain., Noguera-Julian M; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain., Carrillo J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Mitjà O; Fight Infections Foundation, Badalona, Spain.; Hospital Universitari Germans Trias i Pujol, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Lihir Medical Centre, International SOS, Londolovit, Lihir Island, Papua New Guinea., Mateu L; Fight Infections Foundation, Badalona, Spain.; Hospital Universitari Germans Trias i Pujol, Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Autonomous University of Barcelona (UAB), Barcelona, Spain., Massanella M; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Ballana E; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Martinez-Picado J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Publikováno v: Microbiology spectrum [Microbiol Spectr] 2023 Mar 21, pp. e0415922. Date of Electronic Publication: 2023 Mar 21.
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