Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells

Autor: László Hackler, Árpád Balázs, Ildikó Madarász, Ferhan Ayaydin, Róbert Alföldi, Gábor Pócz, Roberta Fajka-Boja, Gábor J. Szebeni, László G. Puskás, Iván Kanizsai

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 10; Pages: 2105
International Journal of Molecular Sciences, Vol 18, Iss 10, p 2105 (2017)
International Journal of Molecular Sciences

Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76c91dfe8523480f75d985c274402b

Stereoselective synthesis of pinane-based β- and γ-amino acids via conjugate addition of lithium amides and nitromethane

Autor: Tamás A. Martinek, Zsolt Szakonyi, Ferenc Fülöp, Árpád Balázs

Publikováno v: Tetrahedron: Asymmetry. 21:2498-2504

Michael addition of dibenzylamine to (−)- and (+)- tert -butyl myrtenate, (−)- 2 and (+)- 2 , derived from (−)- and (+)-myrtenal, furnished monoterpene-based β-amino acid derivatives in highly stereospecific reactions. The resultant amino este

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e8bab46fd8e477261b31d8fbdf91d2
https://doi.org/10.1016/j.tetasy.2010.09.009

Enantioselective addition of diethylzinc to aldehydes catalyzed by γ-amino alcohols derived from (+)- and (−)-α-pinene

Autor: Tamás A. Martinek, Árpád Balázs, Ferenc Fueloep, Zsolt Szakonyi

Publikováno v: Tetrahedron: Asymmetry. 17:199-204

Primary, secondary and tertiary γ-amino alcohols 4, 5, 7 and 9 and 1,3-diamine 6 were synthesized from (+)- and (−)-α-pinene 1 via chiral N-Boc β-amino ester 3a and carboxamide 3b. The amino alcohols and diamine obtained were applied as chiral c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e476ee93cf5b67ca6f5584f5609b05
https://doi.org/10.1016/j.tetasy.2005.12.011

A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones

Autor: Árpád Balázs, Erik V. Van der Eycken, Ferenc Fülöp

Publikováno v: Tetrahedron Letters. 49:4333-4335

An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01c5a36a659cd85b9a0e6e96225de1fb
https://doi.org/10.1016/j.tetlet.2008.05.034

ChemInform Abstract: A Novel, Microwave-Assisted Method for the Synthesis of Alicyclic-Condensed 5H-1,4,6,7-Tetrahydro-1,4-diazepin-5-ones

Autor: Árpád Balázs, Erik V. Van der Eycken, Ferenc Fueloep

Publikováno v: ChemInform. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24a682d4ee02a1ac1e7d47042e76bf52
https://doi.org/10.1002/chin.200841172