Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Áron, Roxin"'
Autor:
Shreya Bendre, Zhengxing Zhang, Hsiou-Ting Kuo, Julie Rousseau, Chengcheng Zhang, Helen Merkens, Áron Roxin, François Bénard, Kuo-Shyan Lin
Publikováno v:
Molecules, Vol 25, Iss 17, p 3854 (2020)
High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK)
Externí odkaz:
https://doaj.org/article/e41216e446474536968dc023ab688d41
Autor:
Áron Roxin, Kuo-Shyan Lin, Francois Benard, Daniel Kwon, Zhengxing Zhang, David M. Perrin, Chengcheng Zhang, Jerome Lozada, Richel Poon, Jutta Zeisler
Publikováno v:
Molecular Pharmaceutics. 18:187-197
C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancers, contributing to proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can enable the detection and characterization of aggressive cancers with poor outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7d94d2a437d2afd53da5c6610252b8
https://doi.org/10.1021/acs.molpharmaceut.0c00785
https://doi.org/10.1021/acs.molpharmaceut.0c00785
Autor:
Mathieu L. Lepage, Áron Roxin, Hsiou-Ting Kuo, David M. Perrin, Rajaguru L Kandasamy, Kuo-Shyan Lin, Sungjoon Huh, Alan Limoges, Joel Kumlin, Francois Benard, Stefan K. Zeisler, Zhengxing Zhang, Helen Merkens
Publikováno v:
ChemBioChem. 21:943-947
We report a single-molecule radiotracer that can be labeled independently with 18 F-fluoride or radiometals (64 Cu, 177 Lu) in a single step. A prostate-specific membrane antigen (PSMA)-targeting ligand, armed with both an organotrifluoroborate and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60de38f970e7a6c1bcd403de19c3753
https://doi.org/10.1002/cbic.201900632
https://doi.org/10.1002/cbic.201900632
Autor:
Francois Benard, Áron Roxin
Publikováno v:
Nuclear Medicine and Immunology ISBN: 9783030812607
This chapter is meant to present readers with detailed accounts of studies that have used either directly labeled or indirectly labeled activated T cells to gain insights into the complex nature of cancer immunotherapy (CIT). The goal of CIT is to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc3440ced360ae6f59a726010953bc5
https://doi.org/10.1007/978-3-030-81261-4_3
https://doi.org/10.1007/978-3-030-81261-4_3
Autor:
Kuo-Shyan Lin, Mathieu L. Lepage, David M. Perrin, Francois Benard, Zhengxing Zhang, Sungjoon Huh, Áron Roxin, Chengcheng Zhang
Publikováno v:
Bioconjugate Chemistry. 30:1210-1219
DOTA is commonly used for radiometal chelation in molecular imaging. Yet in the absence of a radiometal, DOTA is hypothesized to promote renal clearance of 18F-labeled peptide tracers. In light of an increasing interest in the use of F18 for PET, her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c7c3cc892c8f2256be5fc6e5efeef9d
https://doi.org/10.1021/acs.bioconjchem.9b00146
https://doi.org/10.1021/acs.bioconjchem.9b00146
Autor:
Jinhe Pan, Zhibo Liu, Áron Roxin, Helen Merkens, Hsiou-Ting Kuo, Chengcheng Zhang, Francois Benard, Alla Pryyma, Kuo-Shyan Lin, Mathieu L. Lepage, David M. Perrin, Zhengxing Zhang
Publikováno v:
Journal of Nuclear Medicine. 60:1160-1166
After the identification of the high-affinity glutamate-ureido scaffold, the design of several potent 18F- and 68Ga-labeled tracers has allowed spectacular progress in imaging recurrent prostate cancer by targeting the prostate-specific membrane anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6eea4853aeae3edb629a6d180d67db5
https://doi.org/10.2967/jnumed.118.216598
https://doi.org/10.2967/jnumed.118.216598
Autor:
Daniel, Kwon, Jerome, Lozada, Zhengxing, Zhang, Jutta, Zeisler, Richel, Poon, Chengcheng, Zhang, Áron, Roxin, Kuo-Shyan, Lin, David, Perrin, Francois, Benard
Publikováno v:
Molecular pharmaceutics. 18(1)
C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancers, contributing to proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can enable the detection and characterization of aggressive cancers with poor outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deb6d2c58459c7ce38e46b1f94035c6d
https://pubmed.ncbi.nlm.nih.gov/33253591
https://pubmed.ncbi.nlm.nih.gov/33253591
Autor:
Mathieu L. Lepage, Zhengxing Zhang, Francois Benard, Kuo-Shyan Lin, Áron Roxin, David M. Perrin, Sungjoon Huh, Chengcheng Zhang
Publikováno v:
Nuclear Medicine and Biology. 61:11-20
Introduction The transmembrane α4β1 integrin receptor, or very-late antigen 4 (VLA-4), is associated with tumor metastasis and angiogenesis, the development of chemotherapeutic drug resistance, and is overexpressed in multiple myelomas, osteosarcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d96aecb882c17d103ca4170df64a0bdb
https://doi.org/10.1016/j.nucmedbio.2018.02.005
https://doi.org/10.1016/j.nucmedbio.2018.02.005
Autor:
Mathieu L, Lepage, Hsiou-Ting, Kuo, Áron, Roxin, Sungjoon, Huh, Zhengxing, Zhang, Rajaguru, Kandasamy, Helen, Merkens, Joel O, Kumlin, Alan, Limoges, Stefan K, Zeisler, Kuo-Shyan, Lin, François, Bénard, David M, Perrin
Publikováno v:
Chembiochem : a European journal of chemical biology. 21(7)
We report a single-molecule radiotracer that can be labeled independently with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a06ae96caff8745de448a7bd1dfee00e
https://pubmed.ncbi.nlm.nih.gov/31621172
https://pubmed.ncbi.nlm.nih.gov/31621172
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5126-5131
The peptidomimetic, LLP2A, is a specific, high-affinity ligand for α4β1 integrin receptors. Previously, several PEGylated LLP2A conjugates were evaluated in vivo as imaging agents for the detection of lymphoma, leukemia, multiple myeloma and melano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98637b291ff3af9bfd8128a85c4b289f
https://doi.org/10.1016/j.bmcl.2016.08.011
https://doi.org/10.1016/j.bmcl.2016.08.011