Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Autor: Rafael Gonzalez-Cano, Ángeles Montilla-García, Gloria Perazzoli, Jesús M. Torres, Francisco J. Cañizares, Eduardo Fernández-Segura, Michael Costigan, José M. Baeyens, Enrique J. Cobos

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive respo

Externí odkaz: https://doaj.org/article/087deb144f414e6f8565cd3f2e03fe46

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene

Autor: Marta Luna‐Sánchez, Elena Díaz‐Casado, Emanuele Barca, Miguel Ángel Tejada, Ángeles Montilla‐García, Enrique Javier Cobos, Germaine Escames, Dario Acuña‐Castroviejo, Catarina M Quinzii, Luis Carlos López

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 5, Pp 670-687 (2015)

Abstract Primary coenzyme Q10 (CoQ10) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major phenotypes, but a genotype–phenotype correlation is unclear. Here, we compare two mouse mode

Externí odkaz: https://doaj.org/article/f4d8987aef6d405389fe3b02b95dd32d

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

Autor: Miguel Á. Tejada, Inmaculada Bravo-Caparrós, Ángeles Montilla-García, Rafael González-Cano, Enrique J. Cobos, M. Carmen Ruiz-Cantero, Francisco R. Nieto

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)

Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli; the results thus may not fully reflect the human pain phenotype. Alterations in physical and emotional functioning, pain-depressed behaviors and facial pain e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7387286c253198460636f08772c5bea
https://pubmed.ncbi.nlm.nih.gov/32147529

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

Autor: Emanuele Amata, Francesco Punzo, Orazio Prezzavento, Enrique J. Cobos, Ángeles Montilla-García, Maria Dichiara, Antonio Rescifina, Emanuela Arena, Valeria Pittalà, Agostino Marrazzo, Pedro Merino

Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives cis-(+)-1a [cis-(+)-MR200], cis-(-)-1a [cis-(-)-MR201], and trans-(±)-1a [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3a1d40164b75653b933c61f7568b11
http://hdl.handle.net/20.500.11769/315772

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice

Autor: José M. Baeyens, Shane J. F. Cronin, M. Carmen Ruiz-Cantero, Miguel Á. Tejada, Rafael González-Cano, Domagoj Cikes, Cristina Sánchez-Fernández, Josef M. Penninger, Enrique J. Cobos, José Miguel Vela, Ángeles Montilla-García

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(31)

Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa73bcc2b3a0b15c6137d914a716ecc5
https://pubmed.ncbi.nlm.nih.gov/28716934