Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ángeles Martin-Requero"'
Autor:
Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106430- (2024)
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in
Externí odkaz:
https://doaj.org/article/b4e04e092b5c4a59a6337799371bb688
Autor:
Pedro González-Naranjo, Concepción Pérez, Marina González-Sánchez, Adrián Gironda-Martínez, Eugenia Ulzurrun, Fernando Bartolomé, Marcos Rubio-Fernández, Angeles Martin-Requero, Nuria E. Campillo, Juan A. Páez
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2348-2356 (2022)
Multitarget drugs are a promising therapeutic approach against Alzheimer’s disease. In this work, a new family of 5-substituted indazole derivatives with a multitarget profile including cholinesterase and BACE1 inhibition is described. Thus, the sy
Externí odkaz:
https://doaj.org/article/4413ef31a44a48d79464776ae07d0209
Autor:
Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase
Externí odkaz:
https://doaj.org/article/e4f7366995854e60ba83492f730a9c84
Autor:
Guiomar Rodríguez-Periñán, Ana de la Encarnación, Fermín Moreno, Adolfo López de Munain, Ana Martínez, Ángeles Martín-Requero, Carolina Alquézar, Fernando Bartolomé
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 581 (2023)
Loss-of-function (LOF) mutations in GRN gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not f
Externí odkaz:
https://doaj.org/article/80545d043f2641519a191d78c80af40f
Autor:
Eva P. Cuevas, Alberto Rodríguez-Fernández, Valle Palomo, Ana Martínez, Ángeles Martín-Requero
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 385 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau protein and β-amyloid), t
Externí odkaz:
https://doaj.org/article/2d5d8c9de43440c8a7fcedb4fb09d9e3
Autor:
Fernando Bartolome, Noemi Esteras, Angeles Martin-Requero, Claire Boutoleau-Bretonniere, Martine Vercelletto, Audrey Gabelle, Isabelle Le Ber, Tadashi Honda, Albena T. Dinkova-Kostova, John Hardy, Eva Carro, Andrey Y. Abramov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Abnormal mitochondrial function has been found in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Mutations in the p62 gene (also known as SQSTM1) which encodes the p62 protein have been reported in both
Externí odkaz:
https://doaj.org/article/6c3d41bcb5fa43bfac86e75704ab5618
Autor:
Carlota Tosat-Bitrián, Alicia Avis-Bodas, Gracia Porras, Daniel Borrego-Hernández, Alberto García-Redondo, Angeles Martín-Requero, Valle Palomo
Publikováno v:
Nanomaterials, Vol 11, Iss 3, p 671 (2021)
CdSe quantum dots (QDs) are valuable tools for deciphering molecular mechanisms in cells. Their conjugation with antibodies offers a unique staining source with optimal characteristics, including increased photostability and narrow emission spectra,
Externí odkaz:
https://doaj.org/article/74ad87e9834440e5a0cba2c894ae818d
Autor:
Natividad de las Cuevas, Elena Urcelay, Ofelia G Hermida, Rosa A Saíz-Diaz, Félix Bermejo, Matilde S Ayuso, Angeles Martín-Requero
Publikováno v:
Neurobiology of Disease, Vol 13, Iss 3, Pp 254-263 (2003)
Failure of cell cycle regulation in neurons might be critically involved in the process of neurodegeneration in Alzheimer’s disease (AD). We present here evidence to support the hypothesis that cell cycle alterations occur in cells other than neuro
Externí odkaz:
https://doaj.org/article/2cc8da990d3d4e2cbc7b0e7b0c81b819
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 2, Pp 289-298 (2001)
We have recently reported that lymphoblasts from late onset Alzheimer's disease (AD) patients show distinct intracellular pH homeostatic features than those obtained from age-matched healthy donors. Here we report that another distinct feature of AD
Externí odkaz:
https://doaj.org/article/569a8b3925224ff4a624a7bb0dc32604
Autor:
Carolina Alquezar, Noemí Esteras, Ainhoa Alzualde, Fermín Moreno, Matilde S Ayuso, Adolfo López de Munain, Ángeles Martín-Requero
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37057 (2012)
BackgroundMutations in the progranulin (PGRN) gene, leading to haploinsufficiency, cause familial frontotemporal lobar degeneration (FTLD-TDP), although the pathogenic mechanism of PGRN deficit is largely unknown. Allelic loss of PGRN was previously
Externí odkaz:
https://doaj.org/article/8cfb0f14389d4adf9d517184e2e3f24f