Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Ángela M. Valverde"'
Autor:
Patricia Marañón, Esther Rey, Stephania C. Isaza, Hanghang Wu, Patricia Rada, Carmen Choya-Foces, Antonio Martínez-Ruiz, María Ángeles Martín, Sonia Ramos, Carmelo García-Monzón, Francisco Javier Cubero, Ángela M. Valverde, Águeda González-Rodríguez
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103088- (2024)
Acetaminophen (APAP)-induced liver injury is one of the most prevalent causes of acute liver failure (ALF). We assessed the role of the bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 in APAP-induced hepatotoxicity. The molecular mech
Externí odkaz:
https://doaj.org/article/dfecb0de4ea14159adf701f783671f60
Autor:
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany, Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Ángela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vázquez, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115667- (2023)
Soluble epoxide hydrolase (sEH) is a drug target with the potential for therapeutic utility in the areas of inflammation, neurodegenerative disease, chronic pain, and diabetes, among others. Proteolysis-targeting chimeras (PROTACs) molecules offer ne
Externí odkaz:
https://doaj.org/article/5a58d1a50ea04ea4b20efc84ec133208
Autor:
Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background & Aims Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A (BMP8A) as a
Externí odkaz:
https://doaj.org/article/8bdf154a44f54c48aa9adb7e918626e3
Autor:
Meijian Zhang, Emma Barroso, Maria Ruart, Lucía Peña, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesús Balsinde, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115623- (2023)
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached a phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined the effec
Externí odkaz:
https://doaj.org/article/482a0be0b5064142a7d350a00b86da03
Autor:
Laura M. Laiglesia, Xavier Escoté, Neira Sáinz, Elisa Felix-Soriano, Eva Santamaría, María Collantes, Marta Fernández-Galilea, Ignacio Colón-Mesa, Leyre Martínez-Fernández, Tania Quesada-López, Sergio Quesada-Vázquez, Carlos Rodríguez-Ortigosa, José M. Arbones-Mainar, Ángela M. Valverde, J Alfredo Martínez, Jesmond Dalli, Laura Herrero, Silvia Lorente-Cebrián, Francesc Villarroya, María J. Moreno-Aliaga
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101749- (2023)
Objective: Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation and white adipose tissue (
Externí odkaz:
https://doaj.org/article/22820310ff864737969835f5345a7e5e
Autor:
Irma Garcia-Martinez, Rosa Alen, Laura Pereira, Adrián Povo-Retana, Alma M. Astudillo, Ana B. Hitos, Isabel Gomez-Hurtado, Eduardo Lopez-Collazo, Lisardo Boscá, Rubén Francés, Ignacio Lizasoain, María Ángeles Moro, Jesús Balsinde, Manuel Izquierdo, Ángela M. Valverde
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100756- (2023)
Background & Aims: Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD) progression owing to the accumulation of toxic lipids in hepatocytes including saturated fatty acids (SFAs), which activate pro-inflammatory pathways. We investigated
Externí odkaz:
https://doaj.org/article/976cfcba75f4439397449d4932f399d3
Autor:
Vitor Ferreira, Cintia Folgueira, María García-Altares, Maria Guillén, Mónica Ruíz-Rosario, Giada DiNunzio, Irma Garcia-Martinez, Rosa Alen, Christoph Bookmeyer, John G. Jones, Juan C. Cigudosa, Pilar López-Larrubia, Xavier Correig-Blanchar, Roger J. Davis, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102741- (2023)
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight gain and metabolic alterations when administered orally to patients. Recently, we demonstrated that, contrarily to the oral treatment which induces weight gain, OLA
Externí odkaz:
https://doaj.org/article/df70da12cc2d45ac97775fe0e1db3edf
Autor:
Juan de Toro-Martín, Tamara Fernández-Marcelo, Águeda González-Rodríguez, Fernando Escrivá, Ángela M. Valverde, Carmen Álvarez, Elisa Fernández-Millán
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Maternal malnutrition plays a critical role in the developmental programming of later metabolic diseases susceptibility in the offspring, such as obesity and type 2 diabetes. Because the liver is the major organ that produces and supplies bl
Externí odkaz:
https://doaj.org/article/2bbed630aae04048b15d74ee77af2f15
Autor:
Nuria Pescador, Vera Francisco, Patricia Vázquez, Eva María Esquinas, Cristina González-Páramos, M. Pilar Valdecantos, Irma García-Martínez, Andrés A. Urrutia, Laura Ruiz, Carmen Escalona-Garrido, Marc Foretz, Benoit Viollet, Miguel Ángel Fernández-Moreno, Alfonso L. Calle-Pascual, María Jesús Obregón, Julián Aragonés, Ángela M. Valverde
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102171- (2021)
Therapeutic potential of metformin in obese/diabetic patients has been associated to its ability to combat insulin resistance. However, it remains largely unknown the signaling pathways involved and whether some cell types are particularly relevant f
Externí odkaz:
https://doaj.org/article/614b02a0d27042bfa9ad295baf652378
Autor:
Joaquín Navarro del Hierro, Emma Cantero-Bahillo, M. Teresa Fernández-Felipe, Mónica R. García-Risco, Tiziana Fornari, Patricia Rada, Laura Doblado, Vitor Ferreira, Ana B. Hitos, Ángela M. Valverde, María Monsalve, Diana Martin
Publikováno v:
Insects, Vol 13, Iss 10, p 896 (2022)
The mealworm (Tenebrio molitor Linnaeus 1758) is gaining importance as one of the most popular edible insects. Studies focusing on its bioactivities are increasing, although alternative forms of consumption other than the whole insect or flour, such
Externí odkaz:
https://doaj.org/article/5491ee85500845459bdd3c5ed6097cc6