Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability

Autor: Victoria García-Morales, Ángela Gento-Caro, Federico Portillo, Fernando Montero, David González-Forero, Bernardo Moreno-López

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+ chan

Externí odkaz: https://doaj.org/article/5fc0b36f1f5d4f20bc32219df617b7d6

Interfering with lysophosphatidic acid receptor edg2/lpa 1 signalling slows down disease progression in SOD1‐G93A transgenic mice

Autor: Bernardo Moreno-López, Ángela Gento-Caro, Victoria García-Morales, Guillermo Rodríguez-Bey, Esther Vilches-Herrando, Federico Portillo, David González-Forero

Publikováno v: Neuropathology and Applied Neurobiology. 47:1004-1018

Aims Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor neuron (MN) excitability offers an opportunity to uncover further aetiopathogenic mechanisms, ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53aaf98a47122331429c22469fe63e18
https://doi.org/10.1111/nan.12699

Interfering with lysophosphatidic acid receptor edg2/lpa

Autor: Ángela, Gento-Caro, Esther, Vilches-Herrando, Victoria, García-Morales, Federico, Portillo, Guillermo, Rodríguez-Bey, David, González-Forero, Bernardo, Moreno-López

Publikováno v: Neuropathology and applied neurobiologyREFERENCES. 47(7)

Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor neuron (MN) excitability offers an opportunity to uncover further aetiopathogenic mechanisms, neuropr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f81d65a7f3310c5a797b63c9889951f
https://pubmed.ncbi.nlm.nih.gov/33508894

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

Autor: Federico Portillo, Antonio Campos-Caro, Rosa M. Soler, Germán Domínguez-Vías, Noura Issaoui, Laura Gómez-Pérez, David González-Forero, Bernardo Moreno-López, Ángela Gento-Caro, Guillermo Rodríguez-Bey, Victoria García-Morales, Ana Garcera

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-23 (2019)
Nature Communications(2019) 10:3784
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Recercat. Dipósit de la Recerca de Catalunya
Repositorio Abierto de la UdL
Universitad de Lleida

Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium channel TASK1, have overlapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69078e0d9b0cb67d932bea4d3bc45767
https://doi.org/10.1038/s41467-019-11637-4

EFFECTS OF CHRONIC ADMINISTRATION OF THE AUTOTAXIN INHIBITOR PF8380 ON HIGH-FAT DIET-INDUCED BENEFICIAL EFFECTS ON A MOUSE MODEL OF ALS.

Autor: Angela Gento-Caro, Enrique Sánchez-García, Esther Vilches-Herrando, Jorge Ariza-Molina, Bernardo Moreno-López, David González-Forero

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S569- (2023)

Externí odkaz: https://doaj.org/article/3805782c710747a6b96ab9c2479df7f5