Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ángel M. Valdivielso"'
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4814-4846 (2014)
A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in
Externí odkaz:
https://doaj.org/article/3c3b1dc427dc4d95b181225eb599692c
Publikováno v:
ARKIVOC, Vol 2008, Iss 17, Pp 287-294 (2009)
Externí odkaz:
https://doaj.org/article/6e8149501e204bd896a1ed44a6872526
Publikováno v:
RSC Advances. 5:62331-62335
A novel amphiphilic guanidine organocatalyst, efficient for asymmetric aldol reactions of ketones in water at neutral pH, is disclosed. The reaction presented a clear substrate dependence depicting a free energy linear correlation with ee. Intramolec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b820e469b138e69988d3fb8cef2807
https://doi.org/10.1039/c5ra12135c
https://doi.org/10.1039/c5ra12135c
Autor:
M. Teresa García-López, Pilar Ventosa-Andrés, Nikos E. Tsopanoglou, Rosario Herranz, Ioannis Pappos, Ángel M. Valdivielso
Publikováno v:
European Journal of Medicinal Chemistry. 58:98-111
By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of peptide-based ureas and thioureas, including analogues of the PAR1 reference antagonist RWJ-58259, has been designed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0119d8946a77edba1e464e85b99b33aa
https://doi.org/10.1016/j.ejmech.2012.10.015
https://doi.org/10.1016/j.ejmech.2012.10.015
Synthesis and Regioselective Functionalization of Piperazin-2-ones Based on Phe-Gly Pseudodipeptides
Autor:
M. Teresa García-López, Ángel M. Valdivielso, Pilar Ventosa-Andrés, Marta Gutiérrez-Rodríguez, Rosario Herranz
Publikováno v:
European Journal of Organic Chemistry. 2013:155-161
The synthesis of 1,4-unsubstituted piperazin-2-ones by one-pot reductive cyclization of PheΨ[CH(CN)NH]Gly pseudodipeptides is described. Studies on the reactivity of the piperazin-2-one ring showed a higher reactivity at the N4 position than at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db360903dcd5410720839bc861de975a
https://doi.org/10.1002/ejoc.201201221
https://doi.org/10.1002/ejoc.201201221
Publikováno v:
ARKIVOC, Vol 2008, Iss 17, Pp 287-294 (2009)
A significant improvement on the synthesis of the PAR-1 antagonist RWJ-58259 is described, which involves a base-related two-fold yield increase in the indazole N-alkylation, and an easier purification and a nine-fold yield increase in the urea forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7499251ed410340954416b30b0d70bc
https://doi.org/10.3998/ark.5550190.0009.h27
https://doi.org/10.3998/ark.5550190.0009.h27
Autor:
Pilar Ventosa-Andrés, Ángel M. Valdivielso, M. Teresa García-López, Juan A. González-Vera, Rosario Herranz
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9313-9322
The scope of acid-mediated cyclative additions of electrophiles to tryptophan-derived α-amino nitriles for the synthesis of 10 b -substituted-1,2,4,5,10 b ,10 c -hexahydropyrrolo[1′,2′,3′:1,9 a ,9]imidazo[1,2- a ]indoles analogues of indole al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb05548cb976055e5c898c992afcf37
https://doi.org/10.1016/j.bmc.2008.08.070
https://doi.org/10.1016/j.bmc.2008.08.070
Autor:
Ángel M. Valdivielso, Jordi Solà, Francesc Puig-Castellví, Romà Tauler, Joan Atcher, Ignacio Alfonso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Dynamic combinatorial libraries (DCLs) are excellent benchmark models to study the stimuli-responsiveness of chemical networks. However, increasingly complex systems are difficult to analyze with simple data analysis methods, because many variables a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4804bd783a876d084eb1dba0a453d5f4
https://doi.org/10.1002/chem.201702442
https://doi.org/10.1002/chem.201702442
Autor:
Ignacio Alfonso, Jordi Solà, Francesc Puig-Castellví, Romà Tauler, Ángel M. Valdivielso, Joan Atcher
Publikováno v:
Chemistry - A European Journal. 23:10700-10700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8561274bab6c695518f4163cc80f2693
https://doi.org/10.1002/chem.201702293
https://doi.org/10.1002/chem.201702293
Publikováno v:
Molecules
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 19, Iss 4, Pp 4814-4846 (2014)
Volume 19
Issue 4
Pages 4814-4846
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 19, Iss 4, Pp 4814-4846 (2014)
Volume 19
Issue 4
Pages 4814-4846
A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fa09bef01cab6b23194d7e644133a8
https://pubmed.ncbi.nlm.nih.gov/24743938
https://pubmed.ncbi.nlm.nih.gov/24743938