Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Álvaro de Mingo Pulido"'
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101464- (2022)
Summary: This protocol has been developed to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents. Inhibitors or antibodies that
Externí odkaz:
https://doaj.org/article/42f549eb18c34c649b8b38a01cd0fc88
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role i
Externí odkaz:
https://doaj.org/article/3a884e93c2014531add0284745c89904
Autor:
Álvaro de Mingo Pulido, Estefanía de Gregorio, Shilpi Chandra, Anna Colell, Albert Morales, Mitchell Kronenberg, Montserrat Marí
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Natural killer T (NKT) cells exhibit a specific tissue distribution, displaying the liver the highest NKT/conventional T cell ratio. Upon antigen stimulation, NKT cells secrete Th1 cytokines, including interferon γ (IFNγ), and Th2 cytokines, includ
Externí odkaz:
https://doaj.org/article/066a6379ff6545d3831b3f4f5fcf7220
Autor:
Paulo C. Rodriguez, José R. Conejo-Garcia, Brian Ruffell, Elsa R. Flores, Sheng Wei, Tara Lee Costich, Carmen M. Anadon, Danielle L. Gilvary, Álvaro de Mingo-Pulido, Yu Cao, Eslam Mohamed, Rosa A. Sierra, Jimena Trillo-Tinoco
Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbceb52a4351325ec5ff06e8f9b49d95
https://doi.org/10.1158/0008-5472.c.6511101.v1
https://doi.org/10.1158/0008-5472.c.6511101.v1
Autor:
Paulo C. Rodriguez, José R. Conejo-Garcia, Brian Ruffell, Elsa R. Flores, Sheng Wei, Tara Lee Costich, Carmen M. Anadon, Danielle L. Gilvary, Álvaro de Mingo-Pulido, Yu Cao, Eslam Mohamed, Rosa A. Sierra, Jimena Trillo-Tinoco
This file contains the Supplementary Figures 1-5. Supplementary Figure 1. Phospho-AMPKα1 levels increase in tumor-MDSC. Supplementary Figure 2. Tumor cell-derived GM-CSF triggers Ampkα expression in MDSC through Stat-5 activation. Supplementary Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0668ce20eec139706e283c0e932888
https://doi.org/10.1158/0008-5472.22421976
https://doi.org/10.1158/0008-5472.22421976
Autor:
Paulo C. Rodriguez, José R. Conejo-Garcia, Brian Ruffell, Elsa R. Flores, Sheng Wei, Tara Lee Costich, Carmen M. Anadon, Danielle L. Gilvary, Álvaro de Mingo-Pulido, Yu Cao, Eslam Mohamed, Rosa A. Sierra, Jimena Trillo-Tinoco
This file contains the Supplementary legends describing the Supplementary Figures 1-5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab67589795b62585b081a6130da4ad2
https://doi.org/10.1158/0008-5472.22421979.v1
https://doi.org/10.1158/0008-5472.22421979.v1
Autor:
Alycia, Gardner, Álvaro, de Mingo Pulido, Kay, Hänggi, Sarah, Bazargan, Alexis, Onimus, Agnieszka, Kasprzak, Jose R, Conejo-Garcia, Katarzyna A, Rejniak, Brian, Ruffell
Publikováno v:
Journal for Immunotherapy of Cancer
Background T cell immunoglobulin and mucin domain containing−3 (TIM-3) blocking antibodies are currently being evaluated in clinical trials for solid and hematological malignancies. Despite its identification on T cells, TIM-3 is predominantly expr
Autor:
Eslam Mohamed, Carmen M. Anadon, Paulo C. Rodriguez, Yu Cao, Álvaro de Mingo-Pulido, Brian Ruffell, Jose R. Conejo-Garcia, Danielle L. Gilvary, Elsa R. Flores, Rosa A. Sierra, Jimena Trillo-Tinoco, Tara Lee Costich, Sheng Wei
Publikováno v:
Cancer Research. 79:5034-5047
Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment
Autor:
Alycia Gardner, Álvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R Conejo-Garcia, Katarzyna A Rejniak, Brian Ruffell
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e003571
BackgroundT cell immunoglobulin and mucin domain containing−3 (TIM-3) blocking antibodies are currently being evaluated in clinical trials for solid and hematological malignancies. Despite its identification on T cells, TIM-3 is predominantly expre
Autor:
Olabisi Osunmakinde, Daiana Pamela Celias, Kay Hänggi, Alexis Onimus, Eslam Mohamed, Bruna Batista-Bittencourt, Xiaoqing Yu, Alycia Gardner, Álvaro de Mingo Pulido, Vincent C. Luca, Hatem Soliman, Tsuneyasu Kaisho, Kristen McEachern, Jie Li, Reymi Peña, Jimena Trillo-Tinoco, Brian Ruffell, Paulo C. Rodriguez, Johanna Kaufmann
Publikováno v:
de Mingo Pulido, Á, Hänggi, K, Celias, D P, Gardner, A, Li, J, Batista-Bittencourt, B, Mohamed, E, Trillo-Tinoco, J, Osunmakinde, O, Peña, R, Onimus, A, Kaisho, T, Kaufmann, J, McEachern, K, Soliman, H, Luca, V C, Rodriguez, P C, Yu, X & Ruffell, B 2021, ' The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake ', Immunity, vol. 54, no. 6, pp. 1154-1167 . https://doi.org/10.1016/j.immuni.2021.04.019
Immunity
Immunity
Blockade of the inhibitory receptor TIM-3 shows efficacy in cancer immunotherapy clinical trials. TIM-3 inhibits production of the chemokine CXCL9 by XCR1+ classical dendritic cells (cDC1), thereby limiting antitumor immunity in mammary carcinomas. W