Výsledky vyhledávání - "Álvaro Villarroel"

Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel

Autor: Rafael Ramis, Óscar R. Ballesteros, Arantza Muguruza-Montero, Sara M-Alicante, Eider Núñez, Álvaro Villarroel, Aritz Leonardo, Aitor Bergara

The family of small-conductance Ca2+-activated potassium ion channels (SK channels) is composed of four members (SK1, SK2, SK3, and SK4) involved in neuron-firing regulation. The gating of these channels depends on the intracellular Ca2+ concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8b98748bca9cd43d008888821e1f25
https://doi.org/10.1101/2022.11.02.514819

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Akademický článek

Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy

Publikováno v: Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116602- (2024)

The development of new molecules for the treatment of calmodulin related cardiovascular or neurodegenerative diseases is an interesting goal. In this work, we introduce a novel strategy with four main steps: (1) chemical synthesis of target molecules

Externí odkaz: https://doaj.org/article/f435f416ade94dcdb41b2eaf45510160

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Akademický článek

Fluorometric Measurement of Calmodulin-Dependent Peptide–Protein Interactions Using Dansylated Calmodulin

Autor: Eider Nuñez, Arantza Muguruza-Montero, Sara Alicante, Alvaro Villarroel

Publikováno v: Bio-Protocol, Vol 14, Iss 7 (2024)

The assessment of peptide–protein interactions is a pivotal aspect of studying the functionality and mechanisms of various bioactive peptides. In this context, it is essential to employ methods that meet specific criteria, including sensitivity, bi

Externí odkaz: https://doaj.org/article/2644bd726cdb4f0b920517658c97874b

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Akademický článek

Redox regulation of KV7 channels through EF3 hand of calmodulin

Autor: Eider Nuñez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel

Publikováno v: eLife, Vol 12 (2023)

Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation of the channels. Recent struct

Externí odkaz: https://doaj.org/article/0bd7d7f107f1445e8d187383cd53a107

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El protocolo de acuerdos de la Ley de presupuestos del sector público

Autor: Álvaro Villarroel Cáceres

Publikováno v: Revista de derecho (Valparaíso) n.38 2012
SciELO Chile
CONICYT Chile
instacron:CONICYT

El trabajo examina como el contexto de las exclusivas facultades del presidente de la Republica en la administracion financiera y, en especial, presupuestaria del Estado, ha posibilitado, a partir de la discusion presupuestaria anual, la aparicion de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735401a986539f18df982969501f6af0
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-68512012000100015

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Akademický článek

An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

Autor: Janire Urrutia, Alejandra Aguado, Carolina Gomis-Perez, Arantza Muguruza-Montero, Oscar R. Ballesteros, Jiaren Zhang, Eider Nuñez, Covadonga Malo, Hee Jung Chung, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)

Abstract Background The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideratio

Externí odkaz: https://doaj.org/article/06cb6d34b83948ddbd9c631e4790026c

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Akademický článek

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)

Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer

Externí odkaz: https://doaj.org/article/df6bf34ea7084a21b91211d2e2dccd09

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Akademický článek

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade

Autor: Miren Revuelta, Janire Urrutia, Alvaro Villarroel, Oscar Casis

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during Alzheimer’s Disease (AD) due to the imbalance in the production vs. clearance. This accumulation of amyloid β deposits triggers microglial activation. Micro

Externí odkaz: https://doaj.org/article/103bb225c1bf4fc4bbe806a00d7df262

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Helix C Regulates Surface Expression of KCNQ2 (kv7.2) Channels

Autor: Meritxell Rourai Ferrer, Paloma Aivar, Álvaro Villarroel Muñoz, Juncal Fernandez Orth, Juan Camilo Gómez Posada, Pilar Areso, Alessandro Alaimo, Teresa Zamalloa

Publikováno v: ResearcherID

KCNQ2 (Kv7.2) subunits is one of the main subunits that give rise to the M-current, which play a prominent role in the control of neuronal excitability. Little is known regarding how the density of KCNQ2 channels at the plasma membrane is controlled.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bffd5d25ea89ee55864371ddb9c9fe
https://doi.org/10.1016/j.bpj.2009.12.2915

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