Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Álvaro O. Ardiles"'
Autor:
Claudia García-Rodríguez, Paula Mujica, Javiera Illanes-González, Araceli López, Camilo Vargas, Juan C. Sáez, Arlek González-Jamett, Álvaro O. Ardiles
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1516 (2023)
Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to interact with membrane proteins such as TRPV2 channels, organic
Externí odkaz:
https://doaj.org/article/e6cb5920c0a0417fa25f8474568496eb
Autor:
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D. Martínez, Álvaro O. Ardiles, Marco Fuenzalida
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 887 (2023)
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichanne
Externí odkaz:
https://doaj.org/article/8ecaa2306d264fb7b9d02fe0f0e00e12
Autor:
Carolina Flores-Muñoz, Francisca García-Rojas, Miguel A. Pérez, Odra Santander, Elena Mery, Stefany Ordenes, Javiera Illanes-González, Daniela López-Espíndola, Arlek M. González-Jamett, Marco Fuenzalida, Agustín D. Martínez, Álvaro O. Ardiles
Publikováno v:
Cells, Vol 11, Iss 22, p 3646 (2022)
Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy and Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic pl
Externí odkaz:
https://doaj.org/article/b2ec816e17904dd487b66dbd7a5d8337
Autor:
Débora Buendía, Tatiana Guncay, Macarena Oyanedel, Makarena Lemus, Alejandro Weinstein, Álvaro O. Ardiles, José Marcos, Adriana Fernandes, Renato Zângaro, Pablo Muñoz
Publikováno v:
Brain Sciences, Vol 12, Iss 10, p 1272 (2022)
Alzheimer’s disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was
Externí odkaz:
https://doaj.org/article/956e26e4626b4ed1b33c2846d507e4df
Autor:
Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Paula Mujica, Ivana Gajardo, Claudio Córdova, Daniela Lopez-Espíndola, Claudia Durán-Aniotz, Claudio Hetz, Pablo Muñoz, Arlek M. Gonzalez-Jamett, Álvaro O. Ardiles
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities rely on defects in sy
Externí odkaz:
https://doaj.org/article/ab9d78fa62b742169a3bbb3f43ce7005
Autor:
Claudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, Álvaro O. Ardiles, Mei Li Díaz-Hung, Giovanni Tamburini, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral-Miranda, Javier Diaz, Matias Fuentealba, Diego Arriagada, Ernesto Muñoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Pablo Sardi, Danilo B. Medinas, Darwin Contreras, Ricardo Piña, Mychael V. Lourenco, Felipe C. Ribeiro, Sergio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G. Palacios, Claudio Hetz
Publikováno v:
Molecular Therapy.
Autor:
Francisca García, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farías, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima, Álvaro O. Ardiles, Cecilia Hidalgo, Tatiana Adasme, Pablo Muñoz
Publikováno v:
Marine Drugs, Vol 18, Iss 6, p 335 (2020)
Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen specie
Externí odkaz:
https://doaj.org/article/c5063f1f59fd4d28ae07eeb71284f2cf
Autor:
Ivana Gajardo, Claudia S. Salazar, Daniela Lopez-Espíndola, Carolina Estay, Carolina Flores-Muñoz, Claudio Elgueta, Arlek M. Gonzalez-Jamett, Agustín D. Martínez, Pablo Muñoz, Álvaro O. Ardiles
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation. Although LTP has received considerable more attention, recent evidences indicate
Externí odkaz:
https://doaj.org/article/bc918fb42ce842238e1240d20e9e6530
Autor:
Claudia Duran-Aniotz, Catalina Rivera-Krstulovic, Natalia Poblete, Álvaro O. Ardiles, Mei Li Díaz, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral Miranda, Javier Diaz, Matias Fuentealba, Ernesto Muñoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Giovanni Tamburini, Danilo B. Medinas, Darwin Contreras, Ricardo Piña, Mychael V. Lourenco, Felipe C. Ribeiro, Sergio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G. Palacios, Claudio Hetz
Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main adaptive pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375ad74064acffde10be3a7c764e1cb4
https://doi.org/10.1101/2022.06.21.496869
https://doi.org/10.1101/2022.06.21.496869
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Although the importance of DNA methylation-dependent gene expression to neuronal plasticity is well established, the dynamics of methylation and demethylation during the induction and expression of synaptic plasticity have not been explored. Here, we
Externí odkaz:
https://doaj.org/article/49c8eeac6a6949969c6012d3dce5bcf7