Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Álvaro Gutiérrez-Uzquiza"'
Autor:
Samuel España, Daniel Sánchez-Parcerisa, Paloma Bragado, Álvaro Gutiérrez-Uzquiza, Almudena Porras, Carolina Gutiérrez-Neira, Andrea Espinosa, Víctor V. Onecha, Paula Ibáñez, Víctor Sánchez-Tembleque, José M. Udías, Luis M. Fraile
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Range verification of clinical protontherapy systems via positron-emission tomography (PET) is not a mature technology, suffering from two major issues: insufficient signal from low-energy protons in the Bragg peak area and biological washou
Externí odkaz:
https://doaj.org/article/d83a2bc1a5274f1d971a315d88f8e44a
Autor:
Lucía Paniagua-Herranz, Irene Moreno, Cristina Nieto-Jiménez, Esther Garcia-Lorenzo, Cristina Díaz-Tejeiro, Adrián Sanvicente, Bernard Doger, Manuel Pedregal, Jorge Ramón, Jorge Bartolomé, Arancha Manzano, Balázs Gyorffy, Álvaro Gutierrez-Uzquiza, Pedro Pérez Segura, Emiliano Calvo, Víctor Moreno, Alberto Ocana
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2222 (2024)
The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical
Externí odkaz:
https://doaj.org/article/c3b8403f9c0744b0baf28b3578bf3380
Autor:
Ángel M. Cuesta, Nerea Palao, Paloma Bragado, Alvaro Gutierrez-Uzquiza, Blanca Herrera, Aránzazu Sánchez, Almudena Porras
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17152 (2023)
Liver cancer represents a major health problem worldwide with growing incidence and high mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely the cellular origin of most HCCs through the accumulation of genetic al
Externí odkaz:
https://doaj.org/article/943f1e68bae441cfaf2ccb165db82142
Autor:
Sara Garcia-Garcia, Maria Rodrigo-Faus, Noelia Fonseca, Sara Manzano, Balázs Győrffy, Alberto Ocaña, Paloma Bragado, Almudena Porras, Alvaro Gutierrez-Uzquiza
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Metastasis is the process of cancer cell dissemination from primary tumors to different organs being the bone the preferred site for metastatic homing of prostate cancer (PCa) cells. Prostate tumorigenesis is a multi-stage process that ultim
Externí odkaz:
https://doaj.org/article/8f492cc077af4106be60cc15dc54728d
Autor:
Álvaro, Gutiérrez-Uzquiza, María, Arechederra, Paloma, Bragado, Julio A, Aguirre-Ghiso, Almudena, Porras
Publikováno v:
The Journal of biological chemistry. 287(4)
We reveal a novel pro-survival role for mammalian p38α in response to H(2)O(2), which involves an up-regulation of antioxidant defenses. The presence of p38α increases basal and H(2)O(2)-induced expression of the antioxidant enzymes: superoxide-dis
Autor:
Sara Manzano, Alvaro Gutierrez-Uzquiza, Paloma Bragado, Celia Sequera, Óscar Herranz, María Rodrigo-Faus, Patricia Jauregui, Stephanie Morgner, Ignacio Rubio, Carmen Guerrero, Almudena Porras
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)
Abstract Glioblastoma (GBM) is the most aggressive tumor from the central nervous system (CNS). The current lack of efficient therapies makes essential to find new treatment strategies. C3G, a guanine nucleotide exchange factor for some Ras proteins,
Externí odkaz:
https://doaj.org/article/e978329d7c2a48ada96ee823801761d3
Autor:
Michael E. March, Alvaro Gutierrez-Uzquiza, Asbjorg Osk Snorradottir, Leticia S. Matsuoka, Noelia Fonseca Balvis, Thorgeir Gestsson, Kenny Nguyen, Patrick M. A. Sleiman, Charlly Kao, Helgi J. Isaksson, Birkir Thor Bragason, Elias Olafsson, Astridur Palsdottir, Hakon Hakonarson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
HCCAA is a dominantly inherited disease which causes brain hemorrhages as a result of mutant cystatin C aggregation in carriers. Here, the authors show that n- acetyl cysteine can prevent aggregation of mutant protein in a cell model system and rever
Externí odkaz:
https://doaj.org/article/a4b751bc357945ceb32e93795210aa97
Autor:
Alejandro Mazal, Juan Antonio Vera Sanchez, Daniel Sanchez-Parcerisa, Jose Manuel Udias, Samuel España, Victor Sanchez-Tembleque, Luis Mario Fraile, Paloma Bragado, Alvaro Gutierrez-Uzquiza, Nuria Gordillo, Gaston Garcia, Juan Castro Novais, Juan Maria Perez Moreno, Lina Mayorga Ortiz, Amaia Ilundain Idoate, Marta Cremades Sendino, Carme Ares, Raymond Miralbell, Niek Schreuder
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Proton therapy has advantages and pitfalls comparing with photon therapy in radiation therapy. Among the limitations of protons in clinical practice we can selectively mention: uncertainties in range, lateral penumbra, deposition of higher LET outsid
Externí odkaz:
https://doaj.org/article/9cfc1ea4757f48b2a8ec3699168cc954
Autor:
Sara Manzano, Alvaro Gutierrez-Uzquiza, Paloma Bragado, Angel M Cuesta, Carmen Guerrero, Almudena Porras
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10018 (2021)
C3G (RAPGEF1) is a guanine nucleotide exchange factor (GEF) for GTPases from the Ras superfamily, mainly Rap1, although it also acts through GEF-independent mechanisms. C3G regulates several cellular functions. It is expressed at relatively high leve
Externí odkaz:
https://doaj.org/article/14314a8657fa4acaa48e01cb3f88b12b
Autor:
Patricia Fernández-Nogueira, Gemma Fuster, Álvaro Gutierrez-Uzquiza, Pere Gascón, Neus Carbó, Paloma Bragado
Publikováno v:
Cancers, Vol 13, Iss 13, p 3146 (2021)
Breast cancer (BrCa) is the leading cause of death among women worldwide, with about one million new cases diagnosed each year. In spite of the improvements in diagnosis, early detection and treatment, there is still a high incidence of mortality and
Externí odkaz:
https://doaj.org/article/ee06135e514e4c28a824b0feb2db1e87