Autophagy Alterations in White and Brown Adipose Tissues of Mice Exercised under Different Training Protocols

Autor: Isaac Tamargo-Gómez, Manuel Fernández-Sanjurjo, Helena Codina-Martínez, Cristina Tomás-Zapico, Eduardo Iglesias-Gutiérrez, Benjamín Fernández-García, Álvaro F. Fernández

Publikováno v: Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 348 (2024)

Background: Autophagy is a conserved catabolic process that promotes cellular homeostasis and health. Although exercise is a well-established inducer of this pathway, little is known about the effects of different types of training protocols on the a

Externí odkaz: https://doaj.org/article/5c3cc669ace34d33b4f18fef2d5b1464

Autophagy Deficiency by Atg4B Loss Leads to Metabolomic Alterations in Mice

Autor: Gemma G. Martínez-García, Raúl F. Pérez, Álvaro F. Fernández, Sylvere Durand, Guido Kroemer, Guillermo Mariño

Publikováno v: Metabolites, Vol 11, Iss 8, p 481 (2021)

Autophagy is an essential protective mechanism that allows mammalian cells to cope with a variety of stressors and contributes to maintaining cellular and tissue homeostasis. Due to these crucial roles and also to the fact that autophagy malfunction

Externí odkaz: https://doaj.org/article/015476da5adb493da8a96f81f931b7a6

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

Autor: Álvaro F. Fernández, Junichi Sadoshima, Chun-yang Huang, Beth Levine, Satvik Mareedu, Peiyong Zhai, Jihoon Nah

Publikováno v: J Clin Invest

Although autophagy is generally protective, uncontrolled or excessive activation of autophagy can be detrimental. However, it is often difficult to distinguish death by autophagy from death with autophagy, and whether autophagy contributes to death i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290f126b32acfae6f87d9f9e9aca42ab
https://doi.org/10.1172/jci132366

Studying Autophagy In Vivo in the Mammary Gland and in Xenograft Samples

Autor: Zhongju Zou, Álvaro F. Fernández, Verena Jendrossek, Silvia Vega-Rubín-de-Celis

Publikováno v: Autophagy and Cancer ISBN: 9781071620700

Autophagy is a dynamic process that can be monitored in multiple ways, both in vitro and in vivo. Studies in mice are a widely used tool to understand multiple diseases and conditions where autophagy plays a role, and therefore autophagic flux measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc2bf3c564fd57a7ae3aa3a0ba6be0c
https://www.ncbi.nlm.nih.gov/pubmed/34972997

Comprehensive autophagy evaluation in cardiac disease models

Autor: Toshiro Saito, Nina Kaludercic, Federico Pietrocola, Maria Chiara Maiuri, Susmita Kaushik, Álvaro F. Fernández, Sebastiano Sciarretta, Francesca Castoldi, Jihoon Nah, Tomokazu Murakawa, Lorenza Iolanda Tsansizi, Martina Semenzato, Julio Madrigal-Matute, Risa Mukai, Yun Chen, Jumpei Ito, Salwa Sebti, Jenny de Bruijn

Publikováno v: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2020, 116 (3), pp.483-504. ⟨10.1093/cvr/cvz233⟩
Cardiovascular Research, 2020, 116 (3), pp.483-504. ⟨10.1093/cvr/cvz233⟩

Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a412a3d69492ae67895d02d1f16f7ef
https://doi.org/10.1093/cvr/cvz233