Výsledky vyhledávání - "Álvaro Cuesta-Marbán"

Akademický článek

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

Autor: Janny A Villa-Pulgarín, Consuelo Gajate, Javier Botet, Alberto Jimenez, Nicole Justies, Rubén E Varela-M, Álvaro Cuesta-Marbán, Ingrid Müller, Manuel Modolell, José L Revuelta, Faustino Mollinedo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005805 (2017)

Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileis

Externí odkaz: https://doaj.org/article/b4bc8ef28cd54018b172542ea561c88d

Zobrazit plný text záznamu

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

Autor: Ingrid Müller, Javier Botet, Faustino Mollinedo, Manuel Modolell, Nicole Justies, José L. Revuelta, Alberto Jiménez, Rubén E. Varela-M, Janny A. Villa-Pulgarin, Consuelo Gajate, Álvaro Cuesta-Marbán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Neglected Tropical Diseases
GREDOS. Repositorio Institucional de la Universidad de Salamanca
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005805 (2017)

[Background]:Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0963ae4f75034eca5f68698ee7724a39
http://hdl.handle.net/10261/154672

Zobrazit plný text záznamu

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae

Autor: Aaron M. Neiman, Alberto Jiménez, Patricia Lisa-Santamaría, Álvaro Cuesta-Marbán, Faustino Mollinedo, José L. Revuelta

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Caspases are a family of proteases that participate in the progression and execution of the apoptotic program. However, regulation of the caspase activation and their substrates has not yet been fully elucidated. Here we explore the effect of the ect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f4796ce5f84bb1afefecdefd636927
https://doi.org/10.1016/j.bbamcr.2008.12.016

Zobrazit plný text záznamu

RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3

Autor: Anne-Françoise Burnol, Katia Cailliau, Edith Browaeys-Poly, Arlette Lescuyer, Christian Widmann, Álvaro Cuesta-Marbán

Publikováno v: Journal of Biological Chemistry, vol. 290, no. 32, pp. 19653-19665
Journal of Biological Chemistry

Fibroblast growth factor receptors (FGFRs) are involved in proliferative and differentiation physiological responses. Deregulation of FGFR-mediated signaling involving the Ras/PI3K/Akt and the Ras/Raf/ERK MAPK pathways is causally involved in the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe83ebabbc3fe033c2cdc6dadd3c077c
https://serval.unil.ch/notice/serval:BIB_591B75C4BDE0

Zobrazit plný text záznamu

The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress

Autor: Christian Widmann, Noureddine Loukili, Álvaro Cuesta-Marbán, Alexandre Regamey, Hadi Khalil, Elettra Santori, Marcel Huber

Publikováno v: Journal of Cell Science, vol. 128, no. 18, pp. 3502-3513
Journal of Cell Science

The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB might be detrimental, directly causing apoptosis of cells or leading to a pers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae7bb14c5aa5d30b05096f30ae3f9d9
https://serval.unil.ch/resource/serval:BIB_07B91BE028FD.P001/REF.pdf

Zobrazit plný text záznamu

Evaluation and validation of commercial antibodies for the detection of Shb

Autor: Güliz Vanli, Álvaro Cuesta-Marbán, Christian Widmann

Publikováno v: PLoS ONE
PLoS One, vol. 12, no. 12, pp. e0188311
PLoS ONE, Vol 12, Iss 12, p e0188311 (2017)

Antibodies are among the most important tools for protein detection but, prior to their usage, proper validation of their appropriateness for given applications is required. The utility of an antibody depends on its sensitivity and specificity. We st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd80e6aadda6ef2c618c6b8723377dd
https://doi.org/10.1371/journal.pone.0188311

Zobrazit plný text záznamu

Alteration of Plasma Membrane Organization by an Anticancer Lysophosphatidylcholine Analogue Induces Intracellular Acidification and Internalization of Plasma Membrane Transporters in Yeast*

Autor: Faustino Mollinedo, Vanina Zaremberg, Teshager Bitew, Christopher R. McMaster, Ola Czyz, Álvaro Cuesta-Marbán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Biological Chemistry; Vol 288

The lysophosphatidylcholine analogue edelfosine is a potent antitumor lipid that targets cellular membranes. The underlying mechanisms leading to cell death remain controversial, although two cellular membranes have emerged as primary targets of edel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad71ebebdd4027df81258049c4b6291e
https://europepmc.org/articles/PMC3605658/

Zobrazit plný text záznamu

Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast

Autor: Valentin Hornillos, Ola Czyz, Luis M. Cacharro, José L. Revuelta, Faustino Mollinedo, Javier Delgado, Vanina Zaremberg, Christopher R. McMaster, Álvaro Cuesta-Marbán, Francisco Amat-Guerri, Javier Botet, Consuelo Gajate, A. Ulises Acuña, Hui Zhang

Publikováno v: Journal of Biological Chemistry; Vol 288
Digital.CSIC. Repositorio Institucional del CSIC
instname

The ether-phospholipid edelfosine, a prototype antitumor lipid (ATL), kills yeast cells and selectively kills several cancer cell types. To gain insight into its mechanism of action, we performed chemogenomic screens in the Saccharomyces cerevisiae g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05b59282a3cb214df751eb5de27f9e6
https://pubmed.ncbi.nlm.nih.gov/23335509

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání