In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Autor: William F. Porto, Luz Irazazabal, Eliane S. F. Alves, Suzana M. Ribeiro, Carolina O. Matos, Állan S. Pires, Isabel C. M. Fensterseifer, Vivian J. Miranda, Evan F. Haney, Vincent Humblot, Marcelo D. T. Torres, Robert E. W. Hancock, Luciano M. Liao, Ali Ladram, Timothy K. Lu, Cesar de la Fuente-Nunez, Octavio L. Franco

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Antimicrobial peptides are considered promising alternatives to antibiotics. Here the authors developed a computational algorithm that starts with peptides naturally occurring in plants and optimizes this starting material to yield new variants which

Externí odkaz: https://doaj.org/article/9fc4525fbb254412958fded74332d577

In silicoCharacterization of Class II Plant Defensins fromArabidopsis thaliana

Autor: William F. Porto, Laura S.M. Costa, Pietra O. Rigueiras, Mariana Rocha Maximiano, Neila B. Damaceno, Állan S. Pires, Octavio L. Franco

Defensins comprise a polyphyletic group of multifunctional defense peptides. Cis-defensins, also known as cysteine stabilized αβ (CSαβ) defensins, are one of the most ancient defense peptide families. In plants, these peptides have been divided i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b0a8ba8429ec4a7388d6c3085aeb6b0
https://doi.org/10.1101/2020.04.27.065185

Antimicrobial activity predictors benchmarking analysis using shuffled and designed synthetic peptides

Autor: William F. Porto, Octavio L. Franco, Állan S. Pires

Publikováno v: Journal of Theoretical Biology. 426:96-103

The antimicrobial activity prediction tools aim to help the novel antimicrobial peptides (AMP) sequences discovery, utilizing machine learning methods. Such approaches have gained increasing importance in the generation of novel synthetic peptides by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426886bc939afbcad7113b6dbb924acc
https://doi.org/10.1016/j.jtbi.2017.05.011

Structural impact analysis of missense SNPs present in the uroguanylin gene by long-term molecular dynamics simulations

Autor: William F. Porto, Octavio L. Franco, Antonio C.S. Marcolino, Állan S. Pires, Sérgio Amorim de Alencar

Publikováno v: Journal of Theoretical Biology. 410:9-17

The guanylate cyclase activator 2B, also known as uroguanylin, is part of the guanylin peptide family, which includes peptides such as guanylin and lymphoguanylin. The guanylin peptides could be related to sodium absorption inhibition and water secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da067175c3e9d1d73320e5632eb60d72
https://doi.org/10.1016/j.jtbi.2016.09.008

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Autor: Eliane S. F. Alves, Luciano M. Lião, Cesar de la Fuente-Nunez, Vívian de Jesus Miranda, William F. Porto, Isabel C. M. Fensterseifer, Robert E. W. Hancock, Állan S. Pires, Vincent Humblot, Evan F. Haney, Timothy K. Lu, Suzana M. Ribeiro, Carolina O. Matos, Marcelo D. T. Torres, Octavio L. Franco, Luz N. Irazazabal, Ali Ladram

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-03746-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-03746-3⟩

Plants are extensively used in traditional medicine, and several plant antimicrobial peptides have been described as potential alternatives to conventional antibiotics. However, after more than four decades of research no plant antimicrobial peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792ce8a45f1fbabd2db7eeae05c1df8a
https://hal.archives-ouvertes.fr/hal-01767730