Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ália dos Santos"'
Autor:
Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah McArthur, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Danielle Lambert, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nucl
Externí odkaz:
https://doaj.org/article/7f493cd90a81442ab6f20bf8a272b5ba
Autor:
Yukti Hari-Gupta, Natalia Fili, Ália dos Santos, Alexander W. Cook, Rosemarie E. Gough, Hannah C. W. Reed, Lin Wang, Jesse Aaron, Tomas Venit, Eric Wait, Andreas Grosse-Berkenbusch, J. Christof M. Gebhardt, Piergiorgio Percipalle, Teng-Leong Chew, Marisa Martin-Fernandez, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a
Externí odkaz:
https://doaj.org/article/fa69ba5631c84cc1bb9164996b3d0270
Autor:
Natalia Fili, Yukti Hari-Gupta, Ália dos Santos, Alexander Cook, Simon Poland, Simon M. Ameer-Beg, Maddy Parsons, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear rece
Externí odkaz:
https://doaj.org/article/14b2334ce9e44248852b7f5d9eafede6
Autor:
Michael Lherbette, Ália dos Santos, Yukti Hari-Gupta, Natalia Fili, Christopher P. Toseland, Iwan A. T. Schaap
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract During growth, differentiation and migration of cells, the nucleus changes size and shape, while encountering forces generated by the cell itself and its environment. Although there is increasing evidence that such mechanical signals are emp
Externí odkaz:
https://doaj.org/article/238f6000e7a14ac5ab9064a834e36ab6
Autor:
Ioannis Emmanouilidis, Natalia Fili, Alexander W. Cook, Yukti Hari-Gupta, Ália dos Santos, Lin Wang, Marisa L. Martin-Fernandez, Peter J. I. Ellis, Christopher P. Toseland
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 288 (2021)
Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which target ele
Externí odkaz:
https://doaj.org/article/9bf91830afad4a3696f861d1728a01cd
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2476
Super-resolution microscopy enables the high-precision localization of proteins. Therefore, it is possible to investigate the spatial organization of proteins within the nucleus to understand how their organization relates to regulation and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e0e4a0a1f670e5886d313dc9f70b0ed
https://pubmed.ncbi.nlm.nih.gov/35635711
https://pubmed.ncbi.nlm.nih.gov/35635711
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2476
Atomic force microscopy is an ideal tool to map topography and mechanical properties of materials on the micro- and nanoscale. Here, we describe its application to measure and analyze the mechanics, in particular the effective Young's elastic modulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8d124c4a0f810ffdbb72a496dc45ba8
https://pubmed.ncbi.nlm.nih.gov/35635704
https://pubmed.ncbi.nlm.nih.gov/35635704
Autor:
Ália dos Santos, Bjork Aston, Bana Alamad, Rosemarie E. Gough, Natalia Fili, Lin Wang, Yukti Hari-Gupta, Christopher P. Toseland, Marisa L. Martin-Fernandez
Publikováno v:
J Biol Chem
Myosin VI is involved in many cellular processes ranging from endocytosis to transcription. This multifunctional potential is achieved through alternative isoform splicing and through interactions of myosin VI with a diverse network of binding partne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501bf5bc7c08a73261087069d74c2364
https://doi.org/10.1074/jbc.ra119.010142
https://doi.org/10.1074/jbc.ra119.010142
Autor:
Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah C. W. Reed, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne, Christopher P. Toseland
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nuclear funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79206f4012b1a69be9757e752d1aac51
https://doi.org/10.1101/2022.02.01.478690
https://doi.org/10.1101/2022.02.01.478690
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c5e9b5231dd49bb9fe5318110d9c6d
https://doi.org/10.1007/978-1-0716-2221-6_13
https://doi.org/10.1007/978-1-0716-2221-6_13