Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H1 , H2 , and H3 receptors

Autor: João Paulo S. Fernandes, Álefe Jhonatas Ramos Barbosa, Gustavo A.B. Fernandes, Michelle Fidelis Corrêa, Jillian G. Baker

Publikováno v: Chemical Biology & Drug Design. 93:89-95

Histamine is a transmitter that activates the four receptors H1 R to H4 R. The H3 R is found in the nervous system as an autoreceptor and heteroreceptor, and controls the release of neurotransmitters, making it a potential drug target for neuropsychi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05675c1a62e60479e28c013a33bb05a6
https://doi.org/10.1111/cbdd.13387

Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

Autor: Diego A. Duarte, Michel Bouvier, Claudio M. Costa-Neto, Richardt G. Landgraf, Larissa B. Teixeira, Aleksandro Martins Balbino, João Paulo S. Fernandes, Álefe Jhonatas Ramos Barbosa, Sarah C. Simões, Michelle Fidelis Corrêa, Lucas T. Parreiras-e-Silva

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson's, and Alzheim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d46f24c8a58462cc1477463ef8a51c
http://journal.frontiersin.org/article/10.3389/fphar.2017.00825/full