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Akademický článek

Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy

Autor: Ferenc István Nagy, Dóra Izabella Adamecz, Ádám Baji, Ágnes Kiricsi, Ildikó Huliák, Andrea Rónavári, Zoltán Kónya, Éva Frank, Mohana Krishna Gopisetty, Mónika Kiricsi

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 584 (2023)

Multidrug resistance (MDR) is a serious hurdle to successful cancer therapy. Here, we examined the efficiency of novel semi-synthetic dihydrotestosterone derivatives, more specifically androstano-arylpyrimidines in inhibiting the efflux activity of A

Externí odkaz: https://doaj.org/article/1dc1502a242c461da9543512d22d9c06

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Akademický článek

Microwave-Assisted Synthesis, Proton Dissociation Processes, and Anticancer Evaluation of Novel D-Ring-Fused Steroidal 5-Amino-1-Arylpyrazoles

Autor: Gergő Mótyán, Ádám Baji, Małgorzata Anna Marć, Mohana Krishna Gopisetty, Dóra I. Adamecz, Mónika Kiricsi, Éva A. Enyedy, Éva Frank

Publikováno v: Applied Sciences, Vol 10, Iss 1, p 229 (2019)

Taking into account the pharmacological relevance of heterocycle-fused natural steroids, the objective of the current study was to develop a multistep reaction sequence for the efficient synthesis of novel D-ring-condensed 5-amino-1-arylpyrazoles fro

Externí odkaz: https://doaj.org/article/fa472267a0364580a33e5b289a4d108a

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Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer

Autor: Éva Frank, Miroslav Peřina, Ádám Baji, Radek Jorda, Márton A. Kiss, Nóra V. May, Václav Bazgier

Publikováno v: The Journal of steroid biochemistry and molecular biology. 211

One of the main directions of steroid research is the preparation of modified derivatives in which, in addition to changes in physicochemical properties, receptor binding is significantly altered, thus a bioactivity different from that of the parent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b78ebe132e3719e36d4977d91d1f7b
https://pubmed.ncbi.nlm.nih.gov/33933576

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Microwave-Assisted Synthesis, Proton Dissociation Processes, and Anticancer Evaluation of Novel D-Ring-Fused Steroidal 5-Amino-1-Arylpyrazoles

Autor: Dóra Izabella Adamecz, Ádám Baji, Małgorzata Anna Marć, Mohana Krishna Gopisetty, Gergő Mótyán, Éva A. Enyedy, Mónika Kiricsi, Éva Frank

Publikováno v: Applied Sciences
Volume 10
Issue 1
Applied Sciences, Vol 10, Iss 1, p 229 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5b9b64144e577ec6b129a8dda7c507

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Multicomponent access to androstano-arylpyrimidines under microwave conditions and evaluation of their anti-cancer activity in vitro

Autor: Tamás Kiss, Éva Frank, Mohana Krishna Gopisetty, Mónika Kiricsi, Nóra Igaz, Dávid Kovács, János Wölfling, Ádám Baji

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 172:79-88

Novel ring D- and A-fused pyrimidines in the androstane series were efficiently synthesized within 10-15min in polar protic solvents under microwave irradiation via two kinds of multicomponent heterocyclization reactions followed by spontaneous or pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a71e07a3704db03740d959355df1a5a
https://doi.org/10.1016/j.jsbmb.2017.06.001

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Regio- and stereoselective synthesis of pregnane-fused isoxazolines by nitril-oxide/alkene 1,3-dipolar cycloaddition and an evaluation of their cell-growth inhibitory effect in vitro

Autor: Ádám Baji, Éva Frank, Gergő Mótyán, István Zupkó

Publikováno v: Journal of Molecular Structure. 1110:143-149

Efficient syntheses of some pregnane-fused isoxazolines from 16-dehydropregnenolone acetate with different arylnitrile oxides were carried out by 1,3-dipolar cycloadditions. The intermolecular ring-closures occurred in a highly regio- and stereoselec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59691b40a230278bcd21d4df1ae298f3
https://doi.org/10.1016/j.molstruc.2016.01.050

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Microwave-assisted one-pot synthesis of steroid–quinoline hybrids and an evaluation of their antiproliferative activities on gynecological cancer cell lines

Autor: Ádám Baji, Imre Ocsovszki, János Wölfling, András Gyovai, Renáta Minorics, Éva Frank, István Zupkó

Publikováno v: RSC Advances. 6:27501-27516

Novel D- and A-ring-fused quinolines in the estrone and 5α-androstane series were efficiently synthesized from the corresponding β-chlorovinyl aldehydes with different arylamines in DMF under microwave irradiation. The rates of the one-pot catalyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f554f2e1d2766e9d04580423b321ed0
https://doi.org/10.1039/c6ra03910c

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Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro

Autor: Imre Ocsovszki, Ádám Baji, János Wölfling, Éva Frank, Gergő Mótyán, Ferenc Kovács, István Zupkó, Gyula Schneider, Izabella Sinka

Publikováno v: Steroids. 126

Novel androstanopyrazoles have been efficiently synthesized from steroidal β-ketoaldehydes with different arylhydrazine hydrochlorides both under acidic and basic conditions. Knorr-type transformations of 16-hydroxymethylene-dehydroepiandrosterone c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935fac09965a40599f1ca24fbd41188
https://pubmed.ncbi.nlm.nih.gov/28803210

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