Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Àkos Gyenis"'
Autor:
Maximilian C. Vonolfen, Fenja L. Meyer zu Altenschildesche, Hyuck-Jin Nam, Susanne Brodesser, Akos Gyenis, Jan Buellesbach, Geanette Lam, Carl S. Thummel, Gilles Storelli
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114693- (2024)
Summary: Nutrient digestion, absorption, and export must be coordinated in the gut to meet the nutritional needs of the organism. We used the Drosophila intestine to characterize the mechanisms that coordinate the fate of dietary lipids. We identifie
Externí odkaz:
https://doaj.org/article/11721f5643b043118c2630a215b08f4e
Autor:
Lisanne J. van’t Sant, María B. Birkisdóttir, Rutger A. Ozinga, Ákos Gyenis, Jan H.J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
BackgroundDietary restriction (DR) is a well-established universal anti-aging intervention, and is neuroprotective in multiple models of nervous system disease, including models with cerebellar pathology. The beneficial effects of DR are associated w
Externí odkaz:
https://doaj.org/article/05f37e514a7d4ece873950e75aac602b
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/44a09dce31cb497bae23d58181211464
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004483 (2014)
Faithful transcription of DNA is constantly threatened by different endogenous and environmental genotoxic effects. Transcription coupled repair (TCR) has been described to stop transcription and quickly remove DNA lesions from the transcribed strand
Externí odkaz:
https://doaj.org/article/391002d91f4243c39e17f890772d5747
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38769 (2012)
Recent genome-wide chromatin immunoprecipitation coupled high throughput sequencing (ChIP-seq) analyses performed in various eukaryotic organisms, analysed RNA Polymerase II (Pol II) pausing around the transcription start sites of genes. In this stud
Externí odkaz:
https://doaj.org/article/58e7ca39af52435997af0374d7a3868d
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- a
Externí odkaz:
https://doaj.org/article/8c65fef761fc4154867530db3ca88371
Autor:
Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose
Externí odkaz:
https://doaj.org/article/0cc0fcac27b44c6fbf79164cbd22e050