Zobrazeno 1 - 10 of 1 093 pro vyhledávání: '"[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication"'
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4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects
Autor: Birus, Robin, El-Awaad, Ehab, Ballentin, Laurens, Alchab, Faten, Aichele, Dagmar, Ettouati, Laurent, Götz, Claudia, Le Borgne, Marc, Jose, Joachim
Publikováno v: FEBS Open Bio
FEBS Open Bio, 2022, 12, pp.394-411. ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Wiley Open Access/Elsevier, 2021, ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Vol 12, Iss 2, Pp 394-411 (2022)
Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer therapy, but only one small-molecule inhibitor has reached clinical trials—CX-4945. In this study, we present the indeno[1,2-b]indole derivative 5-isopropyl-4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5fc80887648f7dbe36bac662669c89
https://repositorium.uni-muenster.de/transfer/miami/e07de578-a357-4ad5-a2a9-5e6e1e7da84e
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3
Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders
Autor: Amel Djoudi, Rodolfo Molina-Peña, Natalia Ferreira, Ilaria Ottonelli, Giovanni Tosi, Emmanuel Garcion, Frank Boury
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, Hyaluronic Acid: A Versatile Polysaccharide for Biomedical Applications 2022, 23 (12174), https://doi.org/10.3390/ijms232012174. ⟨10.3390/ijms232012174⟩
International audience; Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing Nacetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3604f3310aa76c3bb4effa1a7a2144d9
https://pubmed.ncbi.nlm.nih.gov/36293030
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4
Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors
Autor: Fanny Mathias, Cyril Fersing
Publikováno v: Acta Pharmaceutica, Vol 72, Iss 1, Pp 9-34 (2022)
Acta Pharmaceutica
Acta Pharmaceutica, 2021, 72 (1), pp.9-34. ⟨10.2478/acph-2022-0007⟩
Volume 72
Issue 1
Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ad816214f7f2c51e5db1e705e5c392
https://doaj.org/article/a75a0365f24a434498e63f20f2883b84
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5
New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties
Autor: Panpan Ma, Balthazar Toussaint, Enrica Angela Roberti, Noémie Scornet, Axel Santos Silva, Luis Castillo Henríquez, Monique Cadasse, Philippe Négrier, Stéphane Massip, Hanh Dufat, Karim Hammad, Cecilia Baraldi, Maria Cristina Gamberini, Cyrille Richard, Stéphane Veesler, Philippe Espeau, Tu Lee, Yohann Corvis
Publikováno v: Pharmaceutics; Volume 15; Issue 4; Pages: 1102
Pharmaceutics
Pharmaceutics, 2023, 15 (4), pp.1102. ⟨10.3390/pharmaceutics15041102⟩
International audience; This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal. For that purpose, two new 1:1 cocrystals, namely l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e17207e9b87d4db6d91e4d5ffa5128
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6
Reply to ‘Response to 'The opinion of French pulmonologists and palliative care physicians on non-invasive ventilation during palliative sedation at end of life: a nationwide survey’’ ’
Autor: GUASTELLA, Virginie, Greil, Annick, Lambert, C., Lautrette, Alexandre
Publikováno v: BMC Palliative Care
BMC Palliative Care, 2023, 22 (1), pp.17. ⟨10.1186/s12904-023-01128-1⟩
We read with interest the letter by Twycross and al on our article recently published in BMC Palliative Care. The authors suggest that the term palliative sedation has been used inappropriately and they consider that in the situation described the se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedad5337128037585411e05be28878d
https://doi.org/10.1186/s12904-023-01128-1
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7
The effects of foot reflexology on symptoms of discomfort in palliative care: a feasibility study
Autor: Marie Lavarelo Marcolin, Andréa Tarot, Véronique Lombardo, Bruno Pereira, Axelle Van Lander, Virginie Guastella
Publikováno v: BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies, 2023, 23, pp.66. ⟨10.1186/s12906-023-03873-5⟩
Background In palliative care, the relief of discomfort is sought by an overall approach, combining prescribed medication and additional therapies, such as foot reflexology (FR). The main objective of this study was to assess the feasibility of FR in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783427e1343d6ded12f232030bf366d6
https://uca.hal.science/hal-04127088/document
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9
Kinome rewiring during acquired drug resistance in neuroendocrine neoplasms
Autor: Patricia Niccoli, Flora Poizat, David Romano, Marie Lagarde, Sandrine Oziel-Taieb, Catherine Roche, Vincent Garcia, Anne Barlier, Corinne Gerard
Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2021, 28 (1), pp.39-51. ⟨10.1530/ERC-19-0142⟩
International audience; Although there is evidence of a significant rise of neuroendocrine neoplasms (NENs) incidence, current treatments are largely insufficient due to somewhat poor knowledge of these tumours. Despite showing differentiated feature
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2bdf8e0c38690280a4b5088821b406
https://doi.org/10.1530/erc-19-0142
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10
Inappropriate direct oral anticoagulant prescriptions in patients with non-valvular atrial fibrillation: cross-sectional analysis of the French CACAO cohort study in primary care
Autor: Emilie Ferrat, Emmanuelle Boutin, Sylvie Bastuji-Garin, Paul Frappé, Julie Fabre, Philippe Galletout, Vincent Renard, Julien Le Breton
Publikováno v: The British Journal of General Practice
British Journal of General Practice
British Journal of General Practice, Royal College of General Practitioners, 2021, 71 (703), pp.e134-e139. ⟨10.3399/bjgp20X714005⟩
BackgroundDirect oral anticoagulants (DOACs) account for an increasing proportion of prescriptions in patients with non-valvular atrial fibrillation (NVAF) in primary care. Inappropriate dosing of DOACs is a common problem, with under-dosing being a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f56a3fe51418a7fa4d4ea58473f9a5
http://europepmc.org/articles/PMC7846350
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