Luspatercept (RAP-536) modulates oxidative stress without affecting mutation burden in myelodysplastic syndromes

Autor: Meunier Mathieu, Chloé Friedrich, Nicolas Ducrot, Johanna Zannoni, Tondeur Sylvie, Nelly Jerraya, Sophie Rousseaux, Florent Chuffart, Olivier Kosmider, Zoubida Karim, Sophie Park

Publikováno v: Annals of Hematology
Annals of Hematology, 2022, 101 (12), pp.2633-2643. ⟨10.1007/s00277-022-04993-7⟩

International audience; In low-risk myelodysplastic syndrome (LR-MDS), erythropoietin (EPO) is widely used for the treatment of chronic anemia. However, initial response to EPO has time-limited effects. Luspatercept reduces red blood cell transfusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717bcea9fd75544d2123b09dfa93c9de
https://doi.org/10.1007/s00277-022-04993-7

The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer

Autor: Tourneur-Marsille J, Nathalie Guedj, Mathieu Uzzan, M. Collard, Yves Panis, Jean-Pierre Hugot, Dumay A, Jean-Noël Freund, Maryline Roy, Xavier Treton, Eric Ogier-Denis, M. Albuquerque

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 2023, 15 (3), pp.665-687. ⟨10.1016/j.jcmgh.2022.10.016⟩

ObjectiveWhile appendectomy may reduce colorectal inflammation in patients with ulcerative colitis (UC), appendectomy has been suggested to be associated with an increased risk of colitis-associated cancer (CAC). The aim of this study was to explore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a85eddbe2f00823646a84669963803
https://doi.org/10.1016/j.jcmgh.2022.10.016

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis

Autor: Lin Lei, Alix Bruneau, Haquima El Mourabit, Justine Guégan, Trine Folseraas, Sara Lemoinne, Tom Hemming Karlsen, Bénédicte Hoareau, Romain Morichon, Ester Gonzalez‐Sanchez, Claire Goumard, Vlad Ratziu, Pierre Charbord, Jérémie Gautheron, Frank Tacke, Thierry Jaffredo, Axelle Cadoret, Chantal Housset

Publikováno v: Hepatology
Hepatology, In press, ⟨10.1002/hep.32456⟩

International audience; Background and Aims: In liver fibrosis, myofibroblasts derive from HSCs and as yet undefined mesenchymal cells. We aimed to identify portal mesenchymal progenitors of myofibroblasts.Approach and Results: Portal mesenchymal cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bfa4349228cde993649f46f1f361d
https://doi.org/10.1002/hep.32456

Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma

Autor: Quentin Bayard, Pierre Cordier, Camille Péneau, Sandrine Imbeaud, Theo Z. Hirsch, Victor Renault, Jean-Charles Nault, Jean-Frédéric Blanc, Julien Calderaro, Chantal Desdouets, Jessica Zucman-Rossi, Eric Letouzé

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2022, 82 (8), pp.1470-1481. ⟨10.1158/0008-5472.CAN-21-3665⟩
Cancer Research, 2022, 82 (8), pp.1470-1481. ⟨10.1158/0008-5472.CAN-21-3665⟩

Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole-genome sequencing (WGS) to explore in depth the nature of structural variants (SV) induced by replication stress in cyclin-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a592b2955c121f211fc9d610f3d3b4
https://doi.org/10.1158/0008-5472.can-21-3665

Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation

Autor: Liu, Dan, Marie, Jean-Claude, Pelletier, Anne-Laure, Song, Zhuoyao, Ben-Khemis, Marwa, Boudiaf, Kaouthar, Pintard, Coralie, Leger, Thibaut, Terrier, Samuel, Chevreux, Guillaume, El-Benna, Jamel, Dang, Pham My-Chan

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 2022, 13 (4), pp.1073-1093. ⟨10.1016/j.jcmgh.2022.01.003⟩

International audience; BACKGROUND & AIMS: NADPH oxidase 1 (NOX1) has emerged as a prime regulator of intestinal mucosa immunity and homeostasis. Dysregulation of NOX1 may cause inflammatory bowel disease (IBD). It is not clear how NOX1 is regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0d262c7f56dca6454e597cf2438a8e
https://doi.org/10.1016/j.jcmgh.2022.01.003