Zobrazeno 1 - 10
of 3 412
pro vyhledávání: '"[CHIM.THER] Chemical Sciences/Medicinal Chemistry"'
Autor:
Sushovan Dam, Salia Tangara, Claire Hamela, Theo Hattabi, Léo Faïon, Paul Carre, Rudy Antoine, Adrien Herledan, Florence Leroux, Catherine Piveteau, Maxime Eveque, Marion Flipo, Benoit Deprez, Laurent Kremer, Nicolas Willand, Baptiste Villemagne, Ruben C. Hartkoorn
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
International audience; It is critical that novel classes of antituberculosis drugs are developed to combat the increasing burden of infections by multidrug-resistant strains. To identify such a novel class of antibiotics, a chemical library of uniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a644599ffe66ea073b6bc501b605bcac
https://doi.org/10.1021/acs.jmedchem.2c01493
https://doi.org/10.1021/acs.jmedchem.2c01493
Autor:
Alice Miral, Solenn Ferron, Isabelle Rouaud, Dinmukhammed Slyambayev, Latifa Bousarghin, Charline Camuzet, Sandrine Belouzard, Karin Séron, Pierre Le Pogam, Sylvain Tranchimand, Sophie Tomasi
Publikováno v:
Journal of Natural Products
Journal of Natural Products, In press, ⟨10.1021/acs.jnatprod.2c00881⟩
Journal of Natural Products, In press, ⟨10.1021/acs.jnatprod.2c00881⟩
International audience; An endolichenic strain of the Ascomycetaceous Xylaria hypoxylon, cultivated alone or in coculture with another endolichenic fungus Dendrothyrium variisporum, produced seven new bioactive eremophilane sesquiterpenes eremoxylari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a60946972e73ab96b4fa2fb51ad9d05
https://doi.org/10.1021/acs.jnatprod.2c00881
https://doi.org/10.1021/acs.jnatprod.2c00881
Publikováno v:
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, 2022, 29, pp.162-175. ⟨10.1016/j.omtn.2022.06.012⟩
Molecular Therapy-Nucleic Acids, 2022, 29, pp.162-175. ⟨10.1016/j.omtn.2022.06.012⟩
International audience; Decoy technology is a versatile and specific DNA oligonucleotide-based targeting strategy of pathogenic transcription factors (TFs). Chemical modifications of linear decoy oligonucleotides have been made to decrease nuclease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1880152c233d0213574f023784b6a9ec
https://doi.org/10.1016/j.omtn.2022.06.012
https://doi.org/10.1016/j.omtn.2022.06.012
Publikováno v:
Biomaterials Science
Biomaterials Science, In press, ⟨10.1039/D2BM01878K⟩
Biomaterials Science, In press, ⟨10.1039/D2BM01878K⟩
International audience; The alarming and prevailing antimicrobial resistance (AMR) calls urgently for novel antibacterial agents that are effective and stable but do not induce resistance development. Amphiphilic dendrimers are emerging as a promisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8109b384beb78c9fd330213b7b60835
https://doi.org/10.1039/d2bm01878k
https://doi.org/10.1039/d2bm01878k
Autor:
Birus, Robin, El-Awaad, Ehab, Ballentin, Laurens, Alchab, Faten, Aichele, Dagmar, Ettouati, Laurent, Götz, Claudia, Le Borgne, Marc, Jose, Joachim
Publikováno v:
FEBS Open Bio
FEBS Open Bio, 2022, 12, pp.394-411. ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Wiley Open Access/Elsevier, 2021, ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Vol 12, Iss 2, Pp 394-411 (2022)
FEBS Open Bio, 2022, 12, pp.394-411. ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Wiley Open Access/Elsevier, 2021, ⟨10.1002/2211-5463.13346⟩
FEBS Open Bio, Vol 12, Iss 2, Pp 394-411 (2022)
Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer therapy, but only one small-molecule inhibitor has reached clinical trials—CX-4945. In this study, we present the indeno[1,2-b]indole derivative 5-isopropyl-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5fc80887648f7dbe36bac662669c89
https://repositorium.uni-muenster.de/transfer/miami/e07de578-a357-4ad5-a2a9-5e6e1e7da84e
https://repositorium.uni-muenster.de/transfer/miami/e07de578-a357-4ad5-a2a9-5e6e1e7da84e
Autor:
Aliasghar Jarrahpour, Zahra Jowkar, Zahra Haghighijoo, Roghayeh Heiran, Javad Ameri Rad, Véronique Sinou, Florent Rouvier, Christine Latour, Jean Michel Brunel, Namık Özdemir
Publikováno v:
Medicinal Chemistry Research
Medicinal Chemistry Research, Springer Verlag, 2022, 31 (6), pp.1026-1034. ⟨10.1007/s00044-022-02898-8⟩
Medicinal Chemistry Research, 2022, 31 (6), pp.1026-1034. ⟨10.1007/s00044-022-02898-8⟩
Medicinal Chemistry Research, Springer Verlag, 2022, 31 (6), pp.1026-1034. ⟨10.1007/s00044-022-02898-8⟩
Medicinal Chemistry Research, 2022, 31 (6), pp.1026-1034. ⟨10.1007/s00044-022-02898-8⟩
International audience; In our ongoing search for bioactive compounds, a class of novel spiro-β-lactam isatin hybrids has been synthesized through a [2 + 2] cycloaddition reaction from 1-allyl-3-(arylimino)indolin-2-one, ketenes and various aryloxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d00b5489b702855fa94302ad8a14c2
https://doi.org/10.1007/s00044-022-02898-8
https://doi.org/10.1007/s00044-022-02898-8
Autor:
Romain Hany, Jean-Philippe Leyris, Guillaume Bret, Sylvie Mallié, Chamroeun Sar, Maxime Thouaye, Abdallah Hamze, Olivier Provot, Pierre Sokoloff, Jean Valmier, Pascal Villa, Didier Rognan
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩
ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩
International audience; nhibiting receptor tyrosine kinases is commonly achieved by two main strategies targeting either the intracellular kinase domain by low molecular weight compounds or the extracellular ligand-binding domain by monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41fdf03a3233fc02562674c1e8cbb35
https://doi.org/10.1021/acschembio.2c00048
https://doi.org/10.1021/acschembio.2c00048
Autor:
Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
International audience; Antimicrobial resistance (AMR) is a major public health issue, causing 5 million deaths per year. Without any action plan, AMR will be in a near future the leading cause of death ahead of cancer. AMR comes from the ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6701d9007286f34c49758179096ee3b7
https://hal.science/hal-04093378
https://hal.science/hal-04093378
Autor:
Lagardère, Louis, Maurin, Lise, Adjoua, Olivier, Hage, Krystel El, Monmarché, Pierre, Piquemal, Jean-Philip, Hénin, Jérôme
We introduce an efficient and robust method to compute alchemical free energy differences, resulting from the application of multiple walker Adaptive Biasing Force (ABF) in conjunction with strongly damped Langevin $\lambda$-dynamics. Unbiased alchem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62feb03ec0e2b72081cba62284a93db1
https://hal.science/hal-04162777
https://hal.science/hal-04162777
Autor:
Nelia Luviano, Ludovic Halby, Corinne Jallet, Paola B. Arimondo, Celine Cosseau, Christoph Grunau
Biomphalaria glabratais a fresh-water mollusk that serves as obligatory intermediate host toSchistosoma mansoni, agent of the neglected tropical disease schistosomiasis that affects roughly 250 Mio people. One of the ways to control the pathogenic ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba349835bb5e90aa57f6043cde2a6e9
https://hal.science/hal-04157076
https://hal.science/hal-04157076