Zobrazeno 1 - 10
of 39
pro vyhledávání: '"[18f]fpeb"'
Autor:
Afshar Sepideh, Lule Sevda, Yuan Gengyang, Qu Xiying, Pan Chuzhi, Whalen Michael, Brownell Anna-Liisa, Mody Maria
Publikováno v:
Translational Neuroscience, Vol 13, Iss 1, Pp 80-92 (2022)
Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS a
Externí odkaz:
https://doaj.org/article/f5c57d59bdd8426bb7225e7b72fbefc2
Autor:
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118217- (2021)
Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability. Methods: Cognitively nor
Externí odkaz:
https://doaj.org/article/e1f29b61815d49eb8468baa6a3682fc6
Autor:
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We u
Externí odkaz:
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Cassis Varlow, Emily Murrell, Jason P. Holland, Alina Kassenbrock, Whitney Shannon, Steven H. Liang, Neil Vasdev, Nickeisha A. Stephenson
Publikováno v:
Molecules, Vol 25, Iss 4, p 982 (2020)
[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing challen
Externí odkaz:
https://doaj.org/article/ce8ee23d633241c19c6f5880ef6b0269
Autor:
Arash Salardini, Emily C Kemp, Yiyun Huang, Erika A Pugh, Nabeel Nabulsi, Adam P. Mecca, Keunpoong Lim, Ming-Kai Chen, Richard E. Carson, Joanna E. Harris, Christopher H. van Dyck, Stephen M. Strittmatter, Tyler A. Godek, Hannah R. Michalak, Julia W. McDonald
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac5b856268819588b67bd5ea1b92f
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Nicole DellaGioia, Nabeel Nabulsi, Adam P. Mecca, Julia W. McDonald, David Matuskey, Yiyun Huang, Ansel T. Hillmer, Jim Ropchan, Richard E. Carson, Wenzhen Zhao, Zachary Jacobs, Christopher H. van Dyck, Hannah R. Michalak, Irina Esterlis, Kelly Rogers, Keunpoong Lim
Publikováno v:
Neuroimage
NeuroImage, Vol 238, Iss, Pp 118217-(2021)
NeuroImage, Vol 238, Iss, Pp 118217-(2021)
Objective Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability. Methods Cognitively norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42d5a7377d641e8e079f6d41fa06f7f
https://europepmc.org/articles/PMC8378132/
https://europepmc.org/articles/PMC8378132/
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ayon Nandi, Dean F. Wong, Pankhuri Vyas, Elizabeth Berry-Kravis, Dejan B. Budimirovic, Anil Mathur, Samuel D. Martin, Zabecca Brinson, John Seibyl, Olivier Barret, Keith J. Slifer, James Robert Brašić, Danna Jennings, Thomas W. Sedlak, David S. Russell
Publikováno v:
Brain Sciences
Volume 10
Issue 12
Brain Sciences, Vol 10, Iss 899, p 899 (2020)
Volume 10
Issue 12
Brain Sciences, Vol 10, Iss 899, p 899 (2020)
Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5) in fmr1 knockout (KO) mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fa73646c89d6e91728352d7d9981db
https://pubmed.ncbi.nlm.nih.gov/33255214
https://pubmed.ncbi.nlm.nih.gov/33255214
Autor:
Neil Vasdev, Jason P. Holland, Whitney Shannon, Cassis Varlow, Nickeisha A. Stephenson, Alina Kassenbrock, Steven H. Liang, Emily Murrell
Publikováno v:
Molecules, Vol 25, Iss 4, p 982 (2020)
[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6230f541653b2d331660acfa7ab21bc3
https://doi.org/10.5167/uzh-187495
https://doi.org/10.5167/uzh-187495
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.