PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714

Autor: Wei Hu, Donghui Pan, Yalin Wang, Weiqi Bao, Chuantao Zuo, Yihui Guan, Fengchun Hua, Min Yang, Jun Zhao

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Background: In the pathogenesis of Alzheimer's disease (AD), microglia play an increasingly important role. Molecular imaging of neuroinflammatory targeting microglia activation and the high expression of 18-kDa translocator protein (TSPO) has become

Externí odkaz: https://doaj.org/article/d7a707579c124a95aeda91338efe6910

Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands

Autor: Nazem Atassi, Marco L. Loggia, Ahmadreza Rezaei, Sheena Chew, Nicole R. Zürcher, Jacob M. Hooker, Joke De Vocht, Michel Koole, Suma Babu, Donatienne Van Weehaeghe, Chieh-En Jane Tseng, Koen Van Laere, Georg Schramm, Philip Van Damme

Publikováno v: J Nucl Med

Neuroinflammation has been implicated in amyotrophic lateral sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, TSPO radioligands have some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1750bc8810c00d3d3025b25977ef5b6a
https://doi.org/10.2967/jnumed.119.241059

Comparative [

Autor: Na, Niu, Haiqun, Xing, Xuezhu, Wang, Jie, Ding, Zhixin, Hao, Chao, Ren, Jiantao, Ba, Lianfang, Zheng, Chao, Fu, Haiyan, Zhao, Li, Huo

Publikováno v: Adipocyte
article-version (VoR) Version of Record

Brown adipose tissue (BAT) is important in monitoring energy homeostasis and cancer cachexia. Different from white adipose tissue, BAT is characterized by the presence of a large number of mitochondria in adipocytes. Translocator protein 18 kDa (TSPO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54b9a8bcf8f9534c851f897ef1f7049b
https://pubmed.ncbi.nlm.nih.gov/32902340

In vivo assessment of neuroinflammation in progressive multiple sclerosis:a proof of concept study with [18F]DPA714 PET

Autor: Tristan A. Reekie, Sandeep S.V. Golla, Martijn T. Wijburg, Michael Kassiou, Dennis Heijtel, Frederik Barkhof, Albert D. Windhorst, Joep Killestein, Marloes Hagens, Patrick Schober, Robert C. Schuit, Adriaan A. Lammertsma, Anne-Marie van Dam, Martijn D. Steenwijk, Bart N.M. van Berckel, Maqsood Yaqub, John J. P. Brevé

Publikováno v: Hagens, M H J, Golla, S V, Wijburg, M T, Yaqub, M, Heijtel, D, Steenwijk, M D, Schober, P, Brevé, J J P, Schuit, R C, Reekie, T A, Kassiou, M, van Dam, A-M, Windhorst, A D, Killestein, J, Barkhof, F, van Berckel, B N M & Lammertsma, A A 2018, ' In vivo assessment of neuroinflammation in progressive multiple sclerosis : a proof of concept study with [18F]DPA714 PET ', Journal of Neuroinflammation, vol. 15, no. 1, pp. 314 . https://doi.org/10.1186/s12974-018-1352-9, https://doi.org/10.1186/s12974-018-1352-9
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Journal of Neuroinflammation, 15(1). BioMed Central
Journal of Neuroinflammation

Background Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflammation, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a013f5ac65d243a1c5c92cc51ad86b2c
https://research.vumc.nl/en/publications/6c9e25ef-2c2d-4cab-be12-c98729a05a30

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