Zobrazeno 1 - 10
of 25
pro vyhledávání: '"[18F]fluspidine"'
Autor:
Toussaint, Magali, Deutscher-Conrad, Winnie, Kranz, Mathias, Fischer, Steffen, Ludwig, Friedrich-Alexander, Juratli, Tareq A., Patt, Marianne, Wünsch, Bernhard, Schackert, Gabriele, Sabri, Osama, Brust, Peter
Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is in
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84840
https://ul.qucosa.de/api/qucosa%3A84840/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84840/attachment/ATT-0/
Autor:
Magali Toussaint, Winnie Deuther-Conrad, Mathias Kranz, Steffen Fischer, Friedrich-Alexander Ludwig, Tareq A. Juratli, Marianne Patt, Bernhard Wünsch, Gabriele Schackert, Osama Sabri, Peter Brust
Publikováno v:
Molecules, Vol 25, Iss 9, p 2170 (2020)
Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is in
Externí odkaz:
https://doaj.org/article/cb7e0b2c553e412f8e24162757eecf7b
Autor:
Michael R. Hayden, Osama Sabri, Mark Forrest Gordon, Laura Rabinovich, Marianne Patt, Henryk Barthel, Michael Rullmann, Andreas Kluge, Gina Pastino, Georg Becker, Doug Marsteller, Swen Hesse, Helena Knebel, Peter Brust, Thilo Gerhards, Juha-Matti Savola, Marcus Bronzel, Philipp Meyer, Ole Voges, Michal Geva, Igor D. Grachev, Franziska Zientek, Maria Strauss, Bernhard Sattler
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 1103-1115
European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 1103-1115
Pridopidine is an investigational drug in late stage development for the treatment of Huntington disease and originally postulated to act as dopamine stabilizer by modulating dopamine-dependent motor behavior. However, preclinical studies show pridop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4137f555b5abb99b82655a00e1f0ced7
http://europepmc.org/articles/PMC8041674
http://europepmc.org/articles/PMC8041674
Autor:
Mathias Kranz, Ralf Bergmann, Torsten Kniess, Birgit Belter, Christin Neuber, Zhengxin Cai, Gang Deng, Steffen Fischer, Jiangbing Zhou, Yiyun Huang, Peter Brust, Winnie Deuther-Conrad, Jens Pietzsch
Publikováno v:
Molecules, Vol 23, Iss 3, p 702 (2018)
Sigma-1 receptors (Sig1R) are highly expressed in various human cancer cells and hence imaging of this target with positron emission tomography (PET) can contribute to a better understanding of tumor pathophysiology and support the development of ant
Externí odkaz:
https://doaj.org/article/4b39ead641884c72929af2a2d3942c5f
Autor:
Grachev, I. D., Meyer, P. M., Becker, G. A., Bronzel, M., Marsteller, D., Pastino, G., Voges, O., Rabinovich, L., Knebel, H., Zientek, F., Rullmann, M., Sattler, B., Patt, M., Gerhards, T., Strauss, M., Kluge, A., Brust, P., Savola, J.-M., Gordon, M. F., Geva, M., Hesse, S., Barthel, H., Hayden, M. R., Sabri, O.
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging (2021)
Purpose: Pridopidine is an investigational drug for Huntington disease (HD). Pridopidine was originally thought to act as a dopamine stabilizer. However, pridopidine shows highest affinity to the sigma-1 receptor (S1R) and enhances neuroprotection vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4577::8ab4a0db533b975bb49d0f4204eef244
https://www.hzdr.de/publications/Publ-31618-1
https://www.hzdr.de/publications/Publ-31618-1
Autor:
Mathias Kranz, Bernhard Sattler, Nathanael Wüst, Winnie Deuther-Conrad, Marianne Patt, Philipp M. Meyer, Steffen Fischer, Cornelius K. Donat, Bernhard Wünsch, Swen Hesse, Jörg Steinbach, Peter Brust, Osama Sabri
Publikováno v:
Molecules, Vol 21, Iss 9, p 1164 (2016)
The enantiomers of [18F]fluspidine, recently developed for imaging of σ1 receptors, possess distinct pharmacokinetics facilitating their use in different clinical settings. To support their translational potential, we estimated the human radiation d
Externí odkaz:
https://doaj.org/article/f7b48a0904f9449ea9ab6fec095ca300
Autor:
Toussaint, M., Deuther-Conrad, W., Kranz, M., Fischer, S., Ludwig, F.-A., Juratli, T., Patt, M., Wünsch, B., Schackert, G., Sabri, O., Brust, P.
Publikováno v:
Molecules 25(2020)9, 2170
Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sigmaR1), an endoplasmic reticulum chaperone protein, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4577::1047e359bd7ebda573eab5e5140aec28
https://www.hzdr.de/publications/Publ-30895-2
https://www.hzdr.de/publications/Publ-30895-2
Autor:
Meyer, P., Strauss, M., Becker, G., Hesse, S., Bednasch, K., Ettrich, B., Wilke, S., Zientek, F., Rullmann, M., Luthardt, J., Fischer, S., Patt, M., Wünsch, B., Brust, P., Sabri, O.
Publikováno v:
Annual Congress of the European Association of Nuclear Medicine, 12.-16.10.2019, Barcelona, Barcelona, Spain
Aim/Introduction: We have previously shown that the sigma-1 receptor(Sig-1R) availability is increased in unmedicated acute MDD (MDD) using (-)-[18F]Fluspidine PET. In order to assess whether this pathophysiology is progressive, we investigated the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4577::d116ae981dee69f7ee82ebecf430286f
https://www.hzdr.de/publications/Publ-29877-1
https://www.hzdr.de/publications/Publ-29877-1
Akademický článek
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Autor:
Pietzsch, Mathias Kranz, Ralf Bergmann, Torsten Kniess, Birgit Belter, Christin Neuber, Zhengxin Cai, Gang Deng, Steffen Fischer, Jiangbing Zhou, Yiyun Huang, Peter Brust, Winnie Deuther-Conrad, Jens
Publikováno v:
Molecules; Volume 23; Issue 3; Pages: 702
Sigma-1 receptors (Sig1R) are highly expressed in various human cancer cells and hence imaging of this target with positron emission tomography (PET) can contribute to a better understanding of tumor pathophysiology and support the development of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::4abe377b83d051dc15a77c03723abb16