Synthesis and Evaluation of [18F]FEtLos and [18F]AMBF3Los as Novel 18F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

Autor: Martha Sahylí Ortega Pijeira, Paulo Sérgio Gonçalves Nunes, Sofia Nascimento dos Santos, Zhengxing Zhang, Arian Pérez Nario, Efrain Araujo Perini, Walter Miguel Turato, Zalua Rodríguez Riera, Roger Chammas, Philip H. Elsinga, Kuo-Shyan Lin, Ivone Carvalho, Emerson Soares Bernardes

Publikováno v: Molecules, Vol 25, Iss 8, p 1872 (2020)

Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT1Rs), which regulate the renin-angiotensin system (RAS). Therefore, monitoring the physiological and pathologic

Externí odkaz: https://doaj.org/article/9c81daf22cdc46fe97fc724b044dc784

Synthesis and Evaluation of [ ¹⁸ F]FEtLos and [ ¹⁸ F]AMBF 3 Los as Novel ¹⁸ F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors.

Autor: Sahylí Ortega Pijeira M; Radiopharmacy Center, Nuclear and Energy Research Institute (IPEN/CNEN-SP), CEP 05508-000 São Paulo, Brazil., Sérgio Gonçalves Nunes P; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), CEP 14040-903 Ribeirão Preto, Brazil., Nascimento Dos Santos S; Radiopharmacy Center, Nuclear and Energy Research Institute (IPEN/CNEN-SP), CEP 05508-000 São Paulo, Brazil., Zhang Z; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada., Pérez Nario A; Radiopharmacy Center, Nuclear and Energy Research Institute (IPEN/CNEN-SP), CEP 05508-000 São Paulo, Brazil., Araujo Perini E; Radiopharmacy Center, Nuclear and Energy Research Institute (IPEN/CNEN-SP), CEP 05508-000 São Paulo, Brazil., Miguel Turato W; School of Pharmaceutical Sciences-University of São Paulo-USP, CEP 05508-000 São Paulo, Brazil., Rodríguez Riera Z; Departamento de Radioquímica, Instituto Superior de Tecnologías y Ciencias Aplicadas (InSTEC), Universidad de La Habana, CP 10400 La Habana, Cuba., Chammas R; Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo, CEP 01246903 São Paulo, Brazil., H Elsinga P; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Internal Post code: EB79, PO box 30.001, 9700 RB Groningen, The Netherlands., Lin KS; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada., Carvalho I; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP), CEP 14040-903 Ribeirão Preto, Brazil., Soares Bernardes E; Radiopharmacy Center, Nuclear and Energy Research Institute (IPEN/CNEN-SP), CEP 05508-000 São Paulo, Brazil.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 Apr 18; Vol. 25 (8). Date of Electronic Publication: 2020 Apr 18.