Zobrazeno 1 - 10
of 29
pro vyhledávání: '"*, Kristiina Ylihonko"'
Publikováno v:
The Journal of Antibiotics. 57:502-510
In the course of DNA-fingerprinting our strain collection for antibiotic biosynthesis genes, two different type II polyketide synthase (PKS) gene clusters were observed from Streptomyces sp. PGA64. Phylogenetic analysis placed these together with kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7227584695b6a8c0d83120e22c2ac4e7
https://doi.org/10.7164/antibiotics.57.502
https://doi.org/10.7164/antibiotics.57.502
Autor:
Jaana Kantola, Kaj Räty, Juha Hakala, Tero Kunnari, Sirke Torkkell, Kristiina Ylihonko, Anne Hautala, Pekka Mäntsälä
Publikováno v:
The Journal of Antibiotics. 56:143-153
This paper focuses on study of second and third ring cyclization in anthracycline biosynthesis by a heterologous gene expression. Firstly, anthracycline non-producing Streptomyces peucetius mutant, D2 was heterologously complemented to produce daunom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30aaaf0b1b4b63c3184093c2a31a4ae
https://doi.org/10.7164/antibiotics.56.143
https://doi.org/10.7164/antibiotics.56.143
Autor:
Jaana Kantola, Kaj Räty, Pekka Mäntsälä, Kristiina Ylihonko, Juha Hakala, Anne Hautala, Sirke Torkkell
Publikováno v:
Microbiology. 148:3375-3384
In this study a set of Streptomyces galilaeus ATCC 31615 mutants was characterized, which are incapable of synthesizing some or all of the deoxyhexose sugars of aclacinomycin A. Complementation experiments with the the mutant strains H026, H038, H039
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a572d97a595a765ee6e865ea3673ad58
https://doi.org/10.1099/00221287-148-11-3375
https://doi.org/10.1099/00221287-148-11-3375
Publikováno v:
Gene. 293:115-122
We have cloned and sequenced polyketide synthase (PKS) genes from the aclacinomycin producer Streptomyces galilaeus ATCC 31,615. The sequenced 13.5-kb region contained 13 complete genes. Their organization as well as their protein sequences showed hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73f5b590bcbe59835c90e743a6db9ef
https://doi.org/10.1016/s0378-1119(02)00699-6
https://doi.org/10.1016/s0378-1119(02)00699-6
Publikováno v:
Molecular and General Genetics MGG. 264:164-172
We have cloned and characterized a gene cluster for anthracycline biosynthesis from Streptomyces galilaeus. This cluster, 15-kb long, includes eight genes involved in the deoxyhexose biosynthesis pathway, a gene for a glycosyltransferase and one for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0ba960a06a57ffaaa10dcd445b3e5
https://doi.org/10.1007/s004380000306
https://doi.org/10.1007/s004380000306
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:396-399
Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater . Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene sno aL, encoding a nogalonic acid methyl est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562577edc33d2e2c0f35f70d588357f
https://doi.org/10.1128/aac.44.2.396-399.2000
https://doi.org/10.1128/aac.44.2.396-399.2000
Publikováno v:
Microbiology. 146:155-163
The anthracycline skeleton is biosynthesized by aromatic (type II) polyketide synthases. Furthermore, three post-polyketide steps are needed to form the basic aglycone of anthracyclines. Auramycinone was produced in Streptomyces lividans by introduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9652e20f370edaca1951b5197c2f8b71
https://doi.org/10.1099/00221287-146-1-155
https://doi.org/10.1099/00221287-146-1-155
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1649-1652
A new approach in the field of polyketide biosynthetic engineering, the combination of the biosynthetic routes of two different sources, is introduced. Streptomyces nogalater genes expressed in S. lividans TK24 yield the hybrid strain TK24/pSY15. Str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ec9ef7c2e914da801faf8173c92220
https://doi.org/10.1039/a903248g
https://doi.org/10.1039/a903248g
Publikováno v:
University of Helsinki
The sno gene cluster in Streptomyces nogalater ATCC 27451 contains the nogalamycin biosynthesis genes. A set of plasmid constructions carrying fragments of the sno cluster that lie downstream of snoD were used to complement the S. galilaeus mutant H0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524eab6735420e00a9558df53bb39974
https://doi.org/10.1007/s004380050562
https://doi.org/10.1007/s004380050562
Publikováno v:
Microbiology. 140:1351-1358
A DNA segment cloned from Streptomyces purpurascens ATCC 25489 close to a region that hybridized to a probe containing part of the actinorhodin polyketide synthase caused S. galilaeus ATCC 31615 to produce new anthracyclines. When transformed with ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b692e739040a4cf4fa7ce170b480d23
https://doi.org/10.1099/00221287-140-6-1351
https://doi.org/10.1099/00221287-140-6-1351