Availability of Central α4β2* Nicotinic Acetylcholine Receptors in Human Obesity

Autor: Eva Schweickert de Palma, Tilman Günnewig, Michael Rullmann, Julia Luthardt, Mohammed K. Hankir, Philipp M. Meyer, Georg-Alexander Becker, Marianne Patt, Sarah Martin, Anja Hilbert, Matthias Blüher, Osama Sabri, Swen Hesse

Publikováno v: Brain Sciences, Vol 12, Iss 12, p 1648 (2022)

Purpose: Obesity is thought to arise, in part, from deficits in the inhibitory control over appetitive behavior. Such motivational processes are regulated by neuromodulators, specifically acetylcholine (ACh), via α4β2* nicotinic ACh receptors (nACh

Externí odkaz: https://doaj.org/article/259b9b4dd35145d8812af1d042779037

(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

Autor: Henryk Barthel, Jörg Steinbach, Steffen Fischer, René Smits, Diego Cecchin, Osama Sabri, Bernhard Sattler, Marianne Patt, Solveig Tiepolt, Julia Luthardt, Georg-Alexander Becker, Alexander Hoepping, Gudrun Wagenknecht, Hermann-Josef Gertz, Michael Rullmann, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Peter Brust, S Wilke, Philipp Meyer, Swen Hesse

Publikováno v: European journal of nuclear medicine and molecular imaging 48(3), 731-746 (2021). doi:10.1007/s00259-020-05029-w
European Journal of Nuclear Medicine and Molecular Imaging

Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[18F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[18F]Flubatine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe5c48d1937d5e2d608c7de7a3b37fb
https://doi.org/10.1007/s00259-020-05029-w

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Characterization of the rotenone mouse model of Parkinson’s disease using radioligands for the adenosine A2A receptor ([18F]FESCH) and the nicotinic α4β2 receptor ((‐)‐[18F]Flubatine)

Autor: Toussaint, M., Kranz, M., Schröder, S., Lai, T. H., Deuther-Conrad, W., Dukic‐Stefanovic, S., Shang, Q., Patt, M., Reichmann, H., Funk, R., Sabri, O., Pan‐Montojo, F., Brust, P.

Publikováno v: 23rd International Symposium on Radiopharmaceutical Sciences (ISRS 2019), 26.-31.05.2019, Beijing, China

Objectives Rotenone-treated mice are regarded as a model for Parkinson´s disease (PD). Increased availability of the adenosine A2A receptor (A2AR) and decreased availability of the α4β2 nicotinic acetylcholine receptor (nAChR) have been found in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::0953b0bb77e55b8262b49eec74379142
https://www.hzdr.de/publications/Publ-29507-1

Exploring the Metabolism of (+)-[18F]Flubatine in vitro and in vivo: LC-MS/MS aided Identification of Radiometabolites in a Clinical PET Study

Autor: Ludwig, F.-A., Fischer, S., Smits, R., Deuther-Conrad, W., Hoepping, A., Tiepolt, S., Patt, M., Sabri, O., Brust, P.

Publikováno v: Molecules 23(2018)1, 464

Both (+)-[18F]flubatine and its enantiomer (-)-[18F]flubatine are radioligands for the neuroimaging of a4ß2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). Within a clinical study in patients with early Alzheimer’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::42a4b8a31243a082105b1280a0cb2328
https://www.hzdr.de/publications/Publ-26846-1