A linear mixed-model approach to study multivariate gene–environment interactions

Autor: 't Hoen, P.A., van Meurs, Joyce B J, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, D.I., Pool, R., van Dongen, J., Hottenga, J.J., Van Greevenbroek, Marleen J., Stehouwer, Coen D A, van der Kallen, Carla J H, Schalkwijk, Casper G, Wijmenga, Cisca, Zhernakova, Alexandra, Tigchelaar, Ettje F, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H, van den Berg, Leonard H, van Duijn, Cornelia M, Hofman, Bert A., Uitterlinden, Andre G, Jhamai, P Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V., Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, P. Szymon M., Swertz, Morris a., van Zwet, Erik W

Publikováno v: Moore, R, Casale, F P, Jan Bonder, M, Horta, D, Franke, L, Barroso, I, Stegle, O & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene–environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0
Nature Genetics, 51(1), 180-186. Nature Publishing Group
't Hoen, P A, van Meurs, J B J, Isaacs, A, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Van Greevenbroek, M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, A, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Iterson, M, van Galen, M, Bot, J, van’t Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Zhernakova, D V, Luijk, R, Jan Bonder, M, van Dijk, F, Arindrarto, W, Kielbasa, P S M, Swertz, M A, van Zwet, E W & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene-environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0

Different environmental factors, including diet, physical activity, or external conditions can contribute to genotype-environment interactions (GxE). Although high-dimensional environmental data are increasingly available, and multiple environments h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329339e0424884e7221abf5b507b437e
https://research.vumc.nl/en/publications/bc3d6aef-b18e-4156-b939-0c5e6c101469

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