Zobrazeno 1 - 10
of 49 457
pro vyhledávání: '"'omics"'
Autor:
Wen Li, Zhining Zhang, Bo Xie, Yunlin He, Kangming He, Hong Qiu, Zhiwei Lu, Chunlan Jiang, Xuanyu Pan, Yuxiao He, Wenyu Hu, Wenjian Liu, Tengcheng Que, Yanling Hu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 659-668 (2024)
Analyzing the vast amount of omics data generated comprehensively by high-throughput sequencing technology is of utmost importance for scientists. In this context, we propose HiOmics, a cloud-based platform equipped with nearly 300 plugins designed f
Externí odkaz:
https://doaj.org/article/cc3d4f483fd84cf4ac82b8b3937ad17e
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-26 (2024)
Abstract Background Clear cell renal cell carcinoma (ccRCC) tumours develop and progress via complex remodelling of the kidney epigenome, transcriptome, proteome and metabolome. Given the subsequent tumour and inter-patient heterogeneity, drug-based
Externí odkaz:
https://doaj.org/article/c0ffeed62cb74c2e87e0394d0b82398f
Autor:
Xueyan Wang, Lei Gao, Haiyuan Li, Yanling Ma, Bofang Wang, Baohong Gu, Xuemei Li, Lin Xiang, Yuping Bai, Chenhui Ma, Hao Chen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Purpose The extracellular matrix (ECM) plays a pivotal role in the initiation and progression of hepatocellular carcinoma (HCC) by facilitating the proliferation of HCC cells and enabling resistance to Anoikis. ECM also provide structural su
Externí odkaz:
https://doaj.org/article/6fa87983730948db8228efe2db71bd13
Autor:
Murat Akand, Tim Muilwijk, Ben Van Cleynenbreugel, Thomas Gevaert, Steven Joniau, Frank Van der Aa
Publikováno v:
European Urology Open Science, Vol 70, Iss , Pp 21-27 (2024)
Non–muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease categorized as low, intermediate, high, or very high risk, for which recurrence and progression rates and thus management strategies differ. Current molecular subclassification o
Externí odkaz:
https://doaj.org/article/3652150134e4497f8e472d50feb16b80
Publikováno v:
Animal Nutrition, Vol 19, Iss , Pp 41-55 (2024)
The rumen is an important organ that enables ruminants to digest nutrients. However, the biological mechanism by which the microbiota and its derived fatty acids regulate rumen development is still unclear. In this study, 18 female Haimen goats were
Externí odkaz:
https://doaj.org/article/e379e9b631bd49cb9841e578e2de8a38
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3920-3928 (2024)
Multiplex spatial proteomic methodologies can provide a unique perspective on the molecular and cellular composition of complex biological systems. Several challenges are associated to the analysis of imaging data, specifically in regard to the norma
Externí odkaz:
https://doaj.org/article/7739c30790804c3a90d533c1156801d2
Autor:
Oluwafemi A. Sarumi, Dominik Heider
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3498-3505 (2024)
Recent advancements in Natural Language Processing (NLP) have been significantly driven by the development of Large Language Models (LLMs), representing a substantial leap in language-based technology capabilities. These models, built on sophisticate
Externí odkaz:
https://doaj.org/article/3da4f7bb375e42bc900bf2104d45615b
Autor:
Jiqing Wu, Viktor H. Koelzer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3481-3488 (2024)
Digital twins in biomedical research, i.e. virtual replicas of biological entities such as cells, organs, or entire organisms, hold great potential to advance personalized healthcare. As all biological processes happen in space, there is a growing in
Externí odkaz:
https://doaj.org/article/0e531bf4eb0843bf8534435682e28ae0
Autor:
Giorgia Migliaccio, Jack Morikka, Giusy del Giudice, Maaret Vaani, Lena Möbus, Angela Serra, Antonio Federico, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 25, Iss , Pp 143-152 (2024)
Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigat
Externí odkaz:
https://doaj.org/article/6bce4f91d2d447fda049f858a40f4f0c
Publikováno v:
Cell Adhesion & Migration, Vol 18, Iss 1, Pp 1-14 (2024)
Lim Domain and Actin Binding protein1 (lima1) influence cancer cell function. Thus far, functional role of lima1 in cholangiocarcinoma remains unknown. We used public databases, in vitro experiments, and multi-omics analysis to investigate the Lima1
Externí odkaz:
https://doaj.org/article/8a2f3f9dc9114105909aae29b7be2228