Výsledky vyhledávání - "'Nichlas Davidsen"

Akademický článek

Perfluorooctanesulfonic acid (PFOS) disrupts cadherin-16 in the developing rat thyroid gland

Autor: Nichlas Davidsen, Louise Ramhøj, Anne-Sofie Ravn Ballegaard, Anna Kjerstine Rosenmai, Cecillie Sofie Henriksen, Terje Svingen

Publikováno v: Current Research in Toxicology, Vol 6, Iss , Pp 100154- (2024)

Perfluorooctanesulfonic acid (PFOS) can disrupt the thyroid hormone (TH) system in rodents, potentially affecting perinatal growth and neurodevelopment. Some studies also suggest that gestational exposure to PFOS can lead to lower TH levels throughou

Externí odkaz: https://doaj.org/article/5711583a02a84757aa0eb4a772c0bd42

Zobrazit plný text záznamu

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

Autor: Francesca Pistollato, Ragnhild E. Paulsen, Anna Bal-Price, Erik Ropstad, Hubert Dirven, Donatella Carpi, Hanne Friis Berntsen, Nichlas Davidsen, Anna Jacobsen Lauvås, Emilio Mendoza-de Gyves, Oddvar Myhre

Publikováno v: Reproductive Toxicology (Elmsford, N.y.)
Reproductive Toxicology

Highlights • Mixtures of 29 halogenated POPs were reconstructed based on human blood levels. • In vitro assays permitted to evaluate DNT effects in human iPSC-derived NSCs. • POPs at human blood levels increased proliferating NSCs and decreased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04953bd4eec1a43cfe2b8f8450d8a5c
https://doi.org/10.1016/j.reprotox.2020.12.013

Zobrazit plný text záznamu

Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes:do we have enough knowledge?

Autor: Terje Svingen, Camilla Lindgren Schwartz, Anna Kjerstine Rosenmai, Louise Ramhøj, Hanna Katarina Lilith Johansson, Ulla Hass, Monica Kam Draskau, Nichlas Davidsen, Sofie Christiansen, Anne-Sofie Ravn Ballegaard, Marta Axelstad

Publikováno v: Svingen, T, Schwartz, C L, Rosenmai, A K, Ramhøj, L, Johansson, H K L, Hass, U, Draskau, M K, Davidsen, N, Christiansen, S, Ballegaard, A-S R & Axelstad, M 2022, ' Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes : do we have enough knowledge? ', Environmental Pollution, vol. 304, 119242 . https://doi.org/10.1016/j.envpol.2022.119242

Endocrine disrupting chemicals (EDCs) are a matter of great concern. They are ubiquitous in the environment, are considered harmful to humans and wildlife, yet remain challenging to identify based on current international test guidelines and regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd6065b867b6232ab383b08d3c97921
https://orbit.dtu.dk/en/publications/91cbfd9b-f963-46bb-bdff-2e96bb7bd3ce

Zobrazit plný text záznamu

Corrigendum to 'PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes' [Environ. Pollut. 305 (2022) 119340]

Autor: Nichlas Davidsen, Louise Ramhøj, Claus Asger Lykkebo, Indusha Kugathas, Rikke Poulsen, Anna Kjerstine Rosenmai, Bertrand Evrard, Thomas A. Darde, Marta Axelstad, Martin Iain Bahl, Martin Hansen, Frederic Chalmel, Tine Rask Licht, Terje Svingen

Publikováno v: Environmental Pollution. 317:120709

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d247357157eaa2df3606e55311cfeec0
https://doi.org/10.1016/j.envpol.2022.120709

Zobrazit plný text záznamu

PFOS disrupts key developmental pathways during hiPSC-derived cardiomyocyte differentiation in vitro

Autor: Nichlas Davidsen, Louise Ramhøj, Indusha Kugathas, Bertrand Evrard, Thomas A. Darde, Frédéric Chalmel, Terje Svingen, Anna Kjerstine Rosenmai

Publikováno v: Davidsen, N, Ramhøj, L, Kugathas, I, Evrard, B, Darde, T A, Chalmel, F, Svingen, T & Rosenmai, A K 2022, ' PFOS disrupts key developmental pathways during hiPSC-derived cardiomyocyte differentiation in vitro ', Toxicology in Vitro, vol. 85, 105475 . https://doi.org/10.1016/j.tiv.2022.105475
Toxicology in Vitro
Toxicology in Vitro, 2022, 85, pp.105475. ⟨10.1016/j.tiv.2022.105475⟩

International audience; Exposure to perfluorooctanesulfonic acid (PFOS) has been associated with congenital heart disease (CHD) and decreased birth weight. PFOS exposure can disrupt signaling pathways relevant for cardiac development in stem cell-der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e830f1344c2376701c039160c63e9b
https://doi.org/10.1016/j.tiv.2022.105475

Zobrazit plný text záznamu

PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes

Publikováno v: Davidsen, N, Ramhøj, L, Lykkebo, C A, Kugathas, I, Poulsen, R, Rosenmai, A K, Evrard, B, Darde, T A, Axelstad, M, Bahl, M I, Hansen, M, Chalmel, F, Licht, T R & Svingen, T 2022, ' PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes ', Environmental Pollution, vol. 305, 119340 . https://doi.org/10.1016/j.envpol.2022.119340
Environmental Pollution
Environmental Pollution, 2022, 305, pp.119340. ⟨10.1016/j.envpol.2022.119340⟩

International audience; Perfluorooctanesulfonic acid (PFOS) is a persistent anthropogenic chemical that can affect the thyroid hormone system in humans and animals. In adults, thyroid hormones (THs) are regulated by the hypothalamic-pituitarythyroid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f505eb9a7cb3e08120778998f62b3103
https://doi.org/10.1016/j.envpol.2022.119340

Zobrazit plný text záznamu

Creating a human-induced pluripotent stem cell-based NKX2.5 reporter gene assay for developmental toxicity testing

Autor: Bjørn Holst, Mikkel A. Rasmussen, Andreas Frederik Treschow, Karin Lauschke, Camilla Taxvig, Anne Marie Vinggaard, Nichlas Davidsen, Jenny Emnéus

Publikováno v: Lauschke, K, Treschow, A F, Rasmussen, M A, Davidsen, N, Holst, B, Emnéus, J, Taxvig, C & Vinggaard, A M 2021, ' Creating a human-induced pluripotent stem cell-based NKX2.5 reporter gene assay for developmental toxicity testing ', Archives of Toxicology, vol. 95, pp. 1659-1670 . https://doi.org/10.1007/s00204-021-03018-y
Archives of Toxicology

To test large numbers of chemicals for developmental toxicity, rapid in vitro tests with standardized readouts for automated data acquisition are needed. However, the most widely used assay, the embryonic stem cell test, relies on the counting of bea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e1bcdf8eb7a664c03e9f92db7f70e1
https://orbit.dtu.dk/en/publications/a0bbd5fe-6f53-45d7-8ba6-54caa45d0d8c

Zobrazit plný text záznamu

Developmental effects of PFOS, PFOA and GenX in a 3D human induced pluripotent stem cell differentiation model

Autor: Anna Kjerstine Rosenmai, Karin Lauschke, Nichlas Davidsen, Terje Svingen, Anne Marie Vinggaard

Publikováno v: Davidsen, N, Rosenmai, A K, Lauschke, K, Svingen, T & Vinggaard, A M 2021, ' Developmental effects of PFOS, PFOA and GenX in a 3D human induced pluripotent stem cell differentiation model ', Chemosphere, vol. 279, 130624 . https://doi.org/10.1016/j.chemosphere.2021.130624

Polyfluoroalkyl substances (PFASs), including perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), are persistent pollutants routinely found in human blood. PFASs have been associated with health issues such as decreased birth weigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd037ca4b9a58f30fab3187103838e7c
https://orbit.dtu.dk/en/publications/ea865186-f35b-423e-850d-bf4acf42932d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání