An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation

Autor: Manuel O. Jakob, Michael Kofoed-Branzk, Divija Deshpande, Shaira Murugan, Christoph S. N. Klose

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corre

Externí odkaz: https://doaj.org/article/4a4b1e49cc6e48cab0b080c54cbdc743

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Autor: Claire Gaveriaux-Ruff, Rohini Kuner, Peter P. Nawroth, Christoph S. N. Klose, Thomas Fleming, Nitin Agarwal, Anke Tappe-Theodor, Divija Deshpande

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20677-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nat. Commun. 12:426 (2021)

Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983a9d3bf1f4d609ff622e3dd388dc9d
https://doi.org/10.1038/s41467-020-20677-0

Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair

Autor: Raman Agrawal, Peter Angel, Paul R. Reynolds, Stephan Herzig, Varun Kumar, Rainer Peperkok, Marcus A. Mall, Christoffer Gebhardt, Thati Madhusudhan, Satish Ranjan, Martin Zeier, Hans-Peter Hammes, Divija Deshpande, Subrata K. Biswas, Arthur Liesz, Julia Ranzinger, Berend Isermann, Peter P. Nawroth, Hans-Ulrich Häring, Christian Gorzelanny, Thomas Fleming, Stefan Terjung

Publikováno v: Nucleic Acids Res. 45, 10595-10613 (2017)
Nucleic Acids Research

The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the spatio-mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c867d674bd65d399f3332818eefbaa95
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52253

Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells

Autor: Saad Alkahtani, Christos Stournaras, Saud Alarifi, Divija Deshpande, Michael Föller, Eva-Maria Schmidt, Michalis Kounenidakis, Konstantinos Alevizopoulos, Shuchen Gu, Florian Lang

Publikováno v: Cellular Signalling. 25:66-73

Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in colon tumor cells. This mAR-induced actin reorganization was recognized as a critical initial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971f3bca531cbe8b09224e793c954b6b
https://doi.org/10.1016/j.cellsig.2012.08.005

STZ treatment causes depletion of immune cells in sciatic nerve and dorsal root ganglion in mice

Autor: S Vittas, Divija Deshpande, Peter P. Nawroth, Asa Hidmark, Thomas Fleming

Publikováno v: Diabetologie und Stoffwechsel. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::787a430a8b8c2cc0abe1421787e95313
https://doi.org/10.1055/s-0035-1549571