Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Jessica L. Bell"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Sven Hagemann, Danny Misiak, Jessica L. Bell, Tommy Fuchs, Marcell I. Lederer, Nadine Bley, Monika Hämmerle, Ehab Ghazy, Wolfgang Sippl, Johannes H. Schulte, Stefan Hüttelmaier
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)
Abstract Background Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strateg
Externí odkaz:
https://doaj.org/article/ca683df65b6941eab6938839b5d6ab26
Autor:
Jessica C. McAfee, Sool Lee, Jiseok Lee, Jessica L. Bell, Oleh Krupa, Jessica Davis, Kimberly Insigne, Marielle L. Bond, Nanxiang Zhao, Alan P. Boyle, Douglas H. Phanstiel, Michael I. Love, Jason L. Stein, W. Brad Ruzicka, Jose Davila-Velderrain, Sriram Kosuri, Hyejung Won
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100404- (2023)
Summary: Genome-wide association studies (GWASs) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to discern causal variants. We performed a massively parallel rep
Externí odkaz:
https://doaj.org/article/8699b54b8aa149bd9c2642416266fe09
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract A growing number of variants associated with risk for neurodevelopmental disorders have been identified by genome-wide association and whole genome sequencing studies. As common risk variants often fall within large haplotype blocks covering
Externí odkaz:
https://doaj.org/article/bf83b58147614695826af08b10a9044c
Autor:
Katelin M. Allan, Miro A. Astore, Egi Kardia, Sharon L. Wong, Laura K. Fawcett, Jessica L. Bell, Simone Visser, Po-Chia Chen, Renate Griffith, Adam Jaffe, Sheila Sivam, Orazio Vittorio, Serdar Kuyucak, Shafagh A. Waters
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical presentations. We present an integrated in vivo, in silico and in vitro
Externí odkaz:
https://doaj.org/article/983bc3fd05834594ba1500ce3059b03f
In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites
Autor:
Ross W. Stephens, Gregory D. Tredwell, Jessica L. Bell, Karen J. Knox, Lee A. Philip, Tim J. Senden, Michael J. Tapner, Stephanie A. Bickley, Marcel R. Tanudji, Stephen K. Jones
Publikováno v:
Biomaterials Research, Vol 25, Iss 1, Pp 1-9 (2021)
Abstract Background Understanding the regional vascular delivery of particles to tumour sites is a prerequisite for developing new diagnostic and therapeutic composites for treatment of oncology patients. We describe a novel imageable 67Ga-radiolabel
Externí odkaz:
https://doaj.org/article/6604bce6ff884428b4aa04740f8ffd1a
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/03fa24bc1d764caf926296ade6c595f1
Autor:
Danny Misiak, Sven Hagemann, Jessica L. Bell, Bianca Busch, Marcell Lederer, Nadine Bley, Johannes H. Schulte, Stefan Hüttelmaier
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
MYCN gene amplification and upregulated expression are major hallmarks in the progression of high-risk neuroblastoma. MYCN expression and function in modulating gene synthesis in neuroblastoma is controlled at virtually every level, including poorly
Externí odkaz:
https://doaj.org/article/9e16d521f31e40e880ef13446d59b3db
Autor:
Matthew Wong, Yuting Sun, Zhichao Xi, Giorgio Milazzo, Rebecca C. Poulos, Christoph Bartenhagen, Jessica L. Bell, Chelsea Mayoh, Nicholas Ho, Andrew E. Tee, Xiaoqiong Chen, Yang Li, Roberto Ciaccio, Pei Y. Liu, Chen C. Jiang, Qing Lan, Nisitha Jayatilleke, Belamy B. Cheung, Michelle Haber, Murray D. Norris, Xu D. Zhang, Glenn M. Marshall, Jenny Y. Wang, Stefan Hüttelmaier, Matthias Fischer, Jason W. H. Wong, Hongxi Xu, Giovanni Perini, Qihan Dong, Rani E. George, Tao Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorige
Externí odkaz:
https://doaj.org/article/a673d07528164588b51a22500785ed47
Autor:
Jessica L. Bell, Sven Hagemann, Jessica K. Holien, Tao Liu, Zsuzsanna Nagy, Johannes H. Schulte, Danny Misiak, Stefan Hüttelmaier
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5098 (2020)
Neuroblastoma is a common childhood cancer with almost a third of those affected still dying, thus new therapeutic strategies need to be explored. Current experimental therapies focus mostly on inhibiting oncogenic transcription factor signalling. Al
Externí odkaz:
https://doaj.org/article/319afdf41917408997ae7e9da3e4855a