Zobrazeno 61 - 70
of 495
pro vyhledávání: 'Lüllmann-Rauch, Renate'
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
Autor:
Paul Saftig, Diana Dudziak, Susann Hüttl, Michaela Schweizer, Renate Lüllmann-Rauch, Bernd Schröder, Hans-Heinrich Oberg, Ralph Lucius, Ana-Maria Lennon-Duménil, Christian H. K. Lehmann, Dieter Kabelitz, Janna Schneppenheim, Philipp Arnold, Ann-Christine Loock
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(1)
The invariant chain (CD74) mediates assembly and targeting of MHC class II (MHCII) complexes. In endosomes, CD74 undergoes sequential degradation by different proteases, including cathepsin S (CatS) and the intramembrane protease signal peptide pepti
Autor:
Bernd Schröder, Nina Himmerkus, Vincent Everts, Renate Lüllmann-Rauch, Janna Schneppenheim, Nur Gueneli, Andreea P Moraru, Regina Fluhrer, Antonius L.J.J. Bronckers, Theodore J Bervoets, Paul Saftig
Publikováno v:
Journal of Bone and Mineral Research. 28:1622-1630
Intramembrane proteases are critically involved in signal transduction and membrane protein turnover. Signal-peptide-peptidase-like 2a (SPPL2A), a presenilin-homologue residing in lysosomes/late endosomes, cleaves type II-oriented transmembrane prote
PURPOSE. Retinal degeneration is a common feature of several lysosomal storage disorders, including the mucopolysaccharidoses, a group of metabolic disorders that is characterized by widespread accumulation of glycosaminoglycans due to lysosomal enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a899de0b25eb16d98389942cb29a949
https://pub.uni-bielefeld.de/record/2904124
https://pub.uni-bielefeld.de/record/2904124
Autor:
Mareninova, Olga A, Sendler, Matthias, Malla, Sudarshan Ravi, Yakubov, Iskandar, French, Samuel W, Tokhtaeva, Elmira, Vagin, Olga, Oorschot, Viola, Lüllmann-Rauch, Renate, Blanz, Judith, Dawson, David, Klumperman, Judith, Lerch, Markus M, Mayerle, Julia, Gukovsky, Ilya, Gukovskaya, Anna S
Publikováno v:
Cellular and molecular gastroenterology and hepatology, vol 1, iss 6
Background & aimsThe pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::4a61cdf47421739a68e3c464ad13544d
https://escholarship.org/uc/item/5hj3p1dd
https://escholarship.org/uc/item/5hj3p1dd
Autor:
Volkmar Gieselmann, Rudi D'Hooge, Matthias Eckhardt, Renate Lüllmann-Rauch, Detlef Balschun, Stijn Stroobants, Enrico Faldini
Publikováno v:
Behavioural Brain Research. 222:309-314
Arylsulfatase A-deficient (ASA(-/-)) mice constitute an animal model for metachromatic leukodystrophy, a lysosomal storage disorder. We had previously examined the behavioural phenotype of these mice, but were unable to distinguish between proper cog
Autor:
Rudi D'Hooge, Cecilia Weigelt, Volkmar Gieselmann, Claes Andersson, Carl Eistrup, Ulrich Matzner, Jens Fogh, Renate Lüllmann-Rauch, Stijn Stroobants
Publikováno v:
Molecular Therapy. 17(4):600-606
Inherited deficiencies of lysosomal hydrolases cause lysosomal storage diseases (LSDs) that are characterized by a progressive multisystemic pathology and premature death. Repeated intravenous injection of the active counterpart of the deficient enzy
Autor:
Hans Bockhardt, Renate Lüllmann-Rauch
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:45-48
This study was aimed at the question of whether or not the antidepressant zimelidine, which is an amphiphilic cationic compound, can induce generalized lipidosis in animals. Rats were chronically treated with high oral doses (80 mg/kg) of the drug, a
Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1
Autor:
Markus Damme, Katrin Kollmann, Torben Lübke, Rudi D'Hooge, Renate Lüllmann-Rauch, Florian Deuschl, Jörg Kahle
Publikováno v:
FEBS Journal. 276:1356-1369
The retinoid-inducible serine carboxypeptidase 1 (Scpep1; formerly RISC) is a lysosomal matrix protein that was initially identified in a screen for genes induced by retinoic acid. Recently, it has been spotlighted by several proteome analyses of the
Autor:
Stijn Stroobants, Paul Saftig, Renate Lüllmann-Rauch, Claes Andersson, Rudi D'Hooge, Meike Lüdemann, Jens Fogh, Willy Morelle, Judith Blanz, Helena Reuterwall, Jean Claude Michalski
Publikováno v:
Human Molecular Genetics. 17:3437-3445
Despite the progress in the treatment of lysosomal storage disorders (LSDs) mainly by enzyme replacement therapy, only limited success was reported in targeting the appropriate lysosomal enzyme into the brain. This prevents efficient clearance of neu
Autor:
Volkmar Gieselmann, Kerstin Khalaj Hedayati, Hariharasubramanian Ramakrishnan, Hans-Hilmar Goebel, Renate Lüllmann-Rauch, Simon Ngamli Fewou, Matthias Eckhardt, Carsten Wessig, Helena Maier
Publikováno v:
The Journal of Neuroscience. 27:9482-9490
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system a