Zobrazeno 11 - 20
of 21
pro vyhledávání: '"Zoe Alaniz"'
Autor:
Kunal Rai, Jairo Matthews, Linghua Wang, Naval Daver, Zoe Alaniz, Feng Wang, Katarzyna Tomczak, Guillermo Garcia-Manero, Jianhua Zhang, Jin Seon Im, Padmanee Sharma, Gheath Alatrash, Maomao Ding, Jing Ning, Praveen Barrodia, Dapeng Hao, Latasha Little, Koichi Takahashi, Ruiping Wang, Wei Wang, Sreyashi Basu, Patrick K. Reville, Hussein A. Abbas, James P. Allison, Marina Konopleva, Steven M. Kornblau, Michael R. Green, Andrew Futreal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Allogeneic stem cell transplantation can cure relapsed/refractor (R/R) AML via grafted T cells versus leukemia effect, but not a viable option to many patients. By combining azacitidine with nivolumab, we harnessed T cell activity and demo
Autor:
Ruiping Wang, Praveen Barrodia, Jairo T. Mathews, Hussein A. Abbas, Gheath Alatrash, Marina Konopleva, Steven M. Kornblau, Dapeng Hao, Kunal Rai, Patrick K. Reville, Andrew Futreal, Sreyashi Basu, Naval Daver, Latasha Little, Linghua Wang, Katarzyna Tomczak, Koichi Takahashi, Padmanee Sharma, Wei Wang, Maomao Ding, Jianhua Zhang, Guillermo Garcia-Manero, James P. Allison, Jing Ning, Feng Wang, Jin Seon Im, Zoe Alaniz, Michael R. Green
Acute myeloid leukemia (AML) and effector cells of immune checkpoint blockade (ICB) therapy co-reside in a complex bone marrow (BM) milieu. The interplay of tumor intrinsic and microenvironment (TME) mechanisms that influences the response to ICB-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b3a205161dd7a512dcb8c9562a23eb
https://doi.org/10.1101/2020.09.03.278309
https://doi.org/10.1101/2020.09.03.278309
Autor:
Mahesh Basyal, Daisuke Honma, Shinji Tsutsumi, Michael Andreeff, Cedric E. Dos Santos, Naval Daver, Zoe Alaniz, Kyung Hee Chang
Publikováno v:
Blood. 138:2943-2943
Introduction: Treatment of acute myeloid leukemia (AML) in elderly patients has been challenging largely because of their intolerance to intensive therapy and development of therapy resistance. Epigenetic alterations, including aberrant DNA methylati
Autor:
Naval Daver, Michael Andreeff, Eric Slosberg, Kyung Hee Chang, Cedric E. Dos Santos, Zoe Alaniz, Yuki Nishida
Publikováno v:
Blood. 136:27-28
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2 (PRC2), is a highly conserved histone methyltransferase that targets lysine-27 of histone H3. EZH2 is one of the key determinants of cellular sensitivity t
Autor:
Lauren B Ostermann, Michael Andreeff, Rasoul Pourebrahim, Hung Alex Luong, Rafael Heinz Montoya, Zoe Alaniz, Joseph D. Khoury
Publikováno v:
Blood. 136:20-21
TP53 mutations are observed in 5 to10% of de novo AML cases with dismal disease prognosis and response to therapy. We found that MDM2 loss of heterozygosity (MDM2 LOH) in AML was always concomitant with TP53 missense mutations (log2 odds ratio>3, p D
Autor:
Angelique Lin, Duncan Mak, Michael Andreeff, Jared K. Burks, Zoe Alaniz, Muharrem Muftuoglu, Bing Z. Carter
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 20:S206-S207
We designed a 51-parameter mass cytometry panel and interrogated acute myeloid leukemia (AML) heterogeneity to assess cellular hierarchy, anti-apoptotic molecules, exhaustion markers and targets for CAR T-cell therapy in R/R AML. We generated two-dim
Autor:
Michael Andreeff, Angelique J. Lin, Jared K. Burks, Muharrem Muftuoglu, Duncan Mak, Zoe Alaniz, Bing Z. Carter
Publikováno v:
Blood. 136:26-26
Background: The heterogeneous and adaptive nature of AML-associated genomic and proteomic landscape may account for disease relapse and poor prognosis, as therapy-associated selective pressure drives the emergence and expansion of AML clones with fea
Autor:
Zoe Alaniz, Michael Andreeff, Jared K. Burks, Rafael Heinz Montoya, Rasoul Pourebrahim, Lauren B Ostermann
Publikováno v:
Blood. 136:1-1
Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that can differentiate into a variety of lineages and play a critical role in tissue homeostasis upon injury and repair. Previous studies using Osx-Cre transgenic mice have de
p53 Mediated Bone Marrow Mesenchymal Stem Cell Expansion Supports Acute Myeloid Leukemia Development
Autor:
Carlos E. Bueso-Ramos, Peter P. Ruvolo, Steven M. Kornblau, Rasoul Pourebrahimabadi, Joseph D. Khoury, Lauren B Ostermann, Hung Alex Luong, Rafael Heinz Montoya, Zoe Alaniz, Michael Andreeff
Publikováno v:
Blood. 134:523-523
Acute myeloid leukemia (AML) is a heterogeneous disease that develops within a complex microenvironment. Reciprocal interactions between the bone marrow mesenchymal stem/stromal cells (BM-MSCs) and AML cells can promote AML progression and resistance
Autor:
Ken Chen, Wei Wang, Michael Andreeff, Yifei Shen, Christopher B. Benton, P. Andrew Futreal, Marina Konopleva, Vakul Mohanty, Feng Wang, Ghayas C. Issa, Zoe Alaniz, Jeffrey L. Jorgensen, Nicholas Navin
Publikováno v:
Blood. 134:2717-2717
Introduction: Outcomes of adverse risk acute myeloid leukemia (AML) remain dismal. Despite some morphologic remission following therapy, the majority of patients relapse and succumb to their disease. Induction chemotherapy leads to a significant redu