Zobrazeno 81 - 90
of 261
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Cell Death & Differentiation. 9:448-456
We previously reported that overexpression of HSP25 delayed cell growth, increased the level of p21(waf), reduced the levels of cyclin D1, cyclin A and cdc2, and induced radioresistance in L929 cells. In this study, we demonstrated that HSP25 induced
Publikováno v:
The American Journal of Pathology. 160:1069-1075
We investigated the role of galectin-3 in metastasis of human breast carcinoma BT549 cells using the experimental liver metastasis model. Underlying mechanisms were then elucidated using the liver/tumor co-culture and cell culture systems. After intr
Publikováno v:
Cancer Research. 77:5327-5327
Although proteasome inhibitors (PIs) are used as anticancer drugs to treat various cancers, their relative therapeutic efficacy on stem cells vs. bulk cancers remains unknown. Here, we show that stem cells derived from gliomas, GSCs, are up to 1,000-
Autor:
Michael T. Lotze, H.J. Zeh, Daolin Tang, Wen Hou, Rui Kang, David L. Bartlett, Qiuhong Zhang, Ruochan Chen, Yong J. Lee
Publikováno v:
Cell Death & Disease
A hypoxic tumor microenvironment is characteristic of many cancer types, including one of the most lethal, pancreatic cancer. We recently demonstrated that the receptor for advanced glycation end products (RAGE) has an important role in promoting the
Publikováno v:
Toxicology and applied pharmacology. 279(3)
Glioblastoma multiforme (GBM) is the most lethal and aggressive astrocytoma of primary brain tumors in adults. Although there are many clinical trials to induce the cell death of glioblastoma cells, most glioblastoma cells have been reported to be re
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 51:785-790
Purpose: Combined use of 13- cis -retinoic acid (cRA) and interferon-α2a (IFNα) induced significant radiosensitization in human cervical cancer ME-180 cell line, whereas it failed to achieve similar radiation enhancement in HeLa cells. The differen
Publikováno v:
The American Journal of Pathology. 159:1055-1060
Galectin-3 is a β-galactoside-binding protein which regulates many biological processes including cell adhesion, migration, cell growth, tumor progression, metastasis, and apoptosis. Although the exact function of galectin-3 in cancer development is
Publikováno v:
Cancer Gene Therapy. 8:397-404
Tumor cells that express a fusion gene of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1 thymidine kinase (TK) sequences activate and are subsequently killed by the nontoxic prodrugs 5-fluorocytosine and ganciclovir. We have
Autor:
Jessup Jm, Kyung-Hwa Lee, Song Yk, Timothy R. Billiar, Kim Hr, Dai-Wu Seol, Yong J. Lee, Kim Th
Publikováno v:
Oncogene. 20:1476-1485
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL, Apo-2L) is a recently characterized member of the family of programmed cell death-inducing ligands that includes TNF-alpha and CD95L (FasL). It is well known that TRAIL binds to the
Publikováno v:
Cell Death & Differentiation. 8:44-50
Cyclin D1 expression is co-regulated by growth factor and cell adhesion signaling. Cell adhesion to the extracellular matrix activates focal adhesion kinase (FAK), which is essential for cyclin D1 expression. Upon the loss of cell adhesion, cyclin D1