Zobrazeno 61 - 70
of 261
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
International Journal of Hyperthermia. 22:713-728
This study investigated whether hyperthermia can enhance TRAIL-induced apoptotic death.Human prostate adenocarcinoma DU-145, human pancreatic carcinoma MIA PaCa-2 and BxPC-3, human colon fibroblast CCD-33Co and rat prostate endothelial YPEN-1 cells w
Autor:
Teresa G. Hastings, Jun Chen, Yong J. Lee, Armando P. Signore, Qinghua Liang, Zhongfang Weng, Amber D. Van Laar
Publikováno v:
Journal of Neurochemistry. 96:428-443
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of midbrain dopaminergic neurons. In the present study, erythropoietin, a trophic factor that has both hematopoietic and neural protective characteristics, was invest
TRAIL has been shown to induce apoptosis in cancer cells, but in some cases, certain cancer cells are resistant to this ligand. In this study, we explored the ability of representative HSP90 (heat shock protein 90) inhibitor NVP-AUY922 to overcome TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a04d6ec283ada7a9955e24eb741dd94
https://europepmc.org/articles/PMC4276460/
https://europepmc.org/articles/PMC4276460/
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Cell Biology. 170:61-72
We have previously observed that metabolic oxidative stress–induced death domain–associated protein (Daxx) trafficking is mediated by the ASK1–SEK1–JNK1–HIPK1 signal transduction pathway. The relocalized Daxx from the nucleus to the cytopla
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Biological Chemistry. 280:26845-26855
We have previously observed that glucose deprivation activates the ASK1-MEK-MAPK signal transduction pathway. In the present study, we reveal that two scaffolding proteins, JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK
Autor:
Yong J. Lee, Seok Joon Kwon
Publikováno v:
Clinical Cancer Research. 11:4694-4700
Purpose and Experimental Design: Tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low extracellular pH, and nutrient depletion. Although it is well known that hypoxia stimulates the accumulation of hypoxia-induci
Autor:
Jedrzej Antosiewicz, Yan Zeng, Sanjay K. Srivastava, Karen L. Lew, Hui Xiao, Yong J. Lee, Dong Xiao, Simon C. Watkins, Anna Herman-Antosiewicz, Shivendra V. Singh, Donald L. Trump, Candace S. Johnson, Sunga Choi
Publikováno v:
Journal of Biological Chemistry. 280:19911-19924
We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by causing apoptosis, but the sequence of events leadin
Publikováno v:
Molecular and Cellular Biochemistry. 270:89-97
Tumor microenvironment, which is characterized by hypoxia, low-glucose concentrations, high-lactate concentrations, low-extracellular pH, can alter the therapeutic response in tumors. In this study, we investigated whether hypoxia affects TRAIL-induc
Autor:
Yong J. Lee, Ki M. Kim
Publikováno v:
Journal of Cellular Biochemistry. 96:376-389
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in numerous transformed cell lines but not in most normal cells. Although this selectivity offers a potential therapeutic application in cancer, not al