Zobrazeno 51 - 60
of 261
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Biochemical Pharmacology. 75:2020-2033
We observed that treatment of prostate cancer cells for 24 h with wogonin, a naturally occurring monoflavonoid, induced cell death in a dose- and time-dependent manner. Exposure of wogonin to LNCaP cells was associated with increased intracellular le
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Cellular Signalling. 20:892-906
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis through caspase activation in a number of cancer cell lines while displaying minimal or no toxicity on normal cells, suggesting that this protein may h
Publikováno v:
Journal of Cellular Biochemistry. 103:1989-1998
Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 that is the key regulator of cellular response to low oxygen tension. Under normoxic conditions, HIF-1alpha is continuously degrad
Autor:
Yong J. Lee, Jinsang Yoo
Publikováno v:
Molecular Pharmacology. 72:1586-1592
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity. TRAIL is known to induce apoptosis in cancer cells but spare most normal cells. In this study, we examined wheth
Publikováno v:
Journal of Biological Chemistry. 282:319-328
Previous studies have shown that repeated application of TRAIL induces acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Using human prostate adenocarcinoma DU-145 and human pancreatic carcinoma MiaPaCa-2 cells a
Autor:
Yong J. Lee, Young-Ho Kim
Publikováno v:
Journal of Cellular Biochemistry. 100:998-1009
TNF-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapy that preferentially induces apoptosis in cancer cells. However, many neoplasms are resistant to TRAIL by mechanisms that are poorly understood. Here we demonstrated that huma
Autor:
Seog-Young, Kim, Se-Hoon, Hong, Per H, Basse, Chuanyue, Wu, David L, Bartlett, Yong Tae, Kwon, Yong J, Lee
Publikováno v:
Journal of cellular biochemistry. 117(10)
Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between CSCs and their counterpart non-stem cells is crucial for developing a novel cancer therapy. We used
Autor:
Dae-Hee, Lee, Ki Sa, Sung, Zong Sheng, Guo, William Taehyung, Kwon, David L, Bartlett, Sang Cheul, Oh, Yong Tae, Kwon, Yong J, Lee
Publikováno v:
Journal of cellular biochemistry. 117(5)
It is well known that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis can be initially triggered by surface death receptors (the extrinsic pathway) and subsequently amplified through mitochondrial dysfunction (the in
Autor:
Evangelia G. Kranias, Xiaoyang Zhou, Jiang Qian, Muhammad Ashraf, Yigang Wang, Guoli Chen, Yong J. Lee, Qunying Yuan, Guojie Song, Guo-Chang Fan
Publikováno v:
Circulation Research. 99:1233-1242
Chronic stimulation of the β-adrenergic neurohormonal axis contributes to the progression of heart failure and mortality in animal models and human patients. In cardiomyocytes, activation of the β-adrenergic pathway has been shown to result in tran
Publikováno v:
Molecular and Cellular Biology. 26:3785-3797
The calcium-calmodulin-activated protein phosphatase calcineurin functions as a key mediator of diverse biologic processes, including differentiation, apoptosis, growth, and adaptive responses, in part through dephosphorylation and activation of nucl