Zobrazeno 11 - 20
of 261
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug therapy
Autor:
Jingyuan Wang, Zhiying Huang, Yue Xi, Hung-Chun Tung, Song Li, Leaf Huang, Jinhan He, Da Yang, Meishu Xu, Sihan Li, Menglin Wang, Songrong Ren, Yanping Li, Haozhe Huang, Wen Xie, Min Zhang, Xinran Cai, Pengfei Xu, Zhengsheng Liu, Yong J. Lee
Publikováno v:
Science Advances. 7
Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis. Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative response that mo...
Autor:
Xu Luo, Yong Seok Park, Kalishwaralal Kalimuthu, M. Haroon A. Choudry, David L. Bartlett, Young Sun Lee, Yong J. Lee
Publikováno v:
Apoptosis
Ferroptosis is considered a distinctive form of cell death compared to other types of death such as apoptosis. It is known to result from iron-dependent accumulation of lipid peroxides rather than caspase activation. However, we reported recently tha
Autor:
Lesley M. Foley, Hima Makala, Haroon A. Choudry, Robin Frederick, Ashok K. Dilly, Jianxia Guo, David L. Bartlett, Jan H. Beumer, T. Kevin Hitchens, Yong J. Lee, Brendon D. Honick, Anuleka Elapavaluru, Lora H. Rigatti, Sachin Velankar
Publikováno v:
Transl Res
Abundant intraperitoneal (IP) accumulation of extracellular mucus in patients with appendiceal mucinous carcinoma peritonei (MCP) causes compressive organ dysfunction and prevents delivery of chemotherapeutic drugs to cancer cells. We hypothesized th
Autor:
Xinxin Song, Haroon A. Choudry, Yong J. Lee, Yong Tae Kwon, Young Sun Lee, David L. Bartlett, Ashok K. Dilly, Dae Hee Lee
Publikováno v:
Molecular Cancer Research. 16:1077-1091
Emerging evidence demonstrates that autophagy and apoptosis are interconnected and their interplay greatly affects cell death. However, the key regulators in this crosstalk remain elusive. Therefore, the role of N-terminal arginylated BiP (R-BiP)/Bec
Autor:
Hima Makala, Kalishwaralal Kalimuthu, Young Sun Lee, Yong Seok Park, Yong J. Lee, Simon C. Watkins, Yong Tae Kwon, M. Haroon A. Choudry, David L. Bartlett
Publikováno v:
J Cell Physiol
Ferroptosis has been reported as a unique form of cell death. However, in recent years, researchers have increasingly challenged the uniqueness of ferroptosis compared to other types of cell death. In this study, we examined whether ferroptosis share
Autor:
Young Sun Lee, Yong J. Lee
Publikováno v:
Ferroptosis in Health and Disease ISBN: 9783030267797
Since its discovery in 2012, ferroptosis has been well characterized as an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species. The endoplasmic reticulum (ER) stress response is one of the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17d4d1db8de9c5be0bb6d1661b5ef573
https://doi.org/10.1007/978-3-030-26780-3_5
https://doi.org/10.1007/978-3-030-26780-3_5
Autor:
Yong J. Lee
Publikováno v:
Cancer Research. 80:1239-1239
Ferroptosis has been reported as a unique form of cell death. However, in recent years, researchers have increasingly challenged the uniqueness of ferroptosis compared to other types of cell death. In this study, we examined whether ferroptosis share
Autor:
Lisa Bailey, David L. Bartlett, Xinxin Song, Se Hoon Hong, William T. Kwon, Yong J. Lee, Yong Tae Kwon, Per H. Basse
Publikováno v:
Molecular Cancer Therapeutics. 15:1591-1601
Since its discovery in 1995, TNF-related apoptosis-inducing ligand (TRAIL) has sparked growing interest among oncologists due to its remarkable ability to induce apoptosis in malignant human cells, but not in most normal cells. However, one major dra
Autor:
Yong J. Lee, Chuanyue Wu, Se Hoon Hong, David L. Bartlett, Seog Young Kim, Yong Tae Kwon, Per H. Basse
Publikováno v:
Journal of Cellular Biochemistry. 117:2289-2301
Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between CSCs and their counterpart non-stem cells is crucial for developing a novel cancer therapy. We used